Results 101 to 110 of about 919,385 (310)

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Journeys Through Jackson 2016 Vol.26 No.01

, 2016
Journeys Through Jackson is the official journal of the Jackson County Genealogical Society, Inc. The journal began as a monthly publication in July 1991, was published bimonthly from 1994 to 2003, and continues today as a quarterly publication.
Jackson County Genealogical Society (N.C.);
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RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Jean Jackson grating manioc tube

, 1969
Jean Jackson grating manioc tuber. Woman behind her is unknown.
Jackson, Jean
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Resultados da avaliação de densidade corporal por meio de diferentes protocolos

Revista Brasileira de Prescrição e Fisiologia do Exercício, 2017
A avaliação física é um processo que visa estimar a qualidade física das pessoas com análise de diversos parâmetros, dentre eles o cálculo da gordura corporal, que pode ser realizado por vários métodos laboratoriais e de campo.
Thainá Caetano Pereira da Silva, Marcelo Henrique Silva, Alexandre Vinícius Malmann Medeiros   +2 more
doaj  

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Jean Jackson receiving body decoration

, 1969
Jean Jackson receiving body decoration (achiote) in preparation for a festival.
Jackson, Jean
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Transcripts with high distal heritability mediate genetic effects on complex metabolic traits

Nature Communications
Although many genes are subject to local regulation, recent evidence suggests that complex distal regulation may be more important in mediating phenotypic variability.
Anna L. Tyler, J. Matthew Mahoney, Mark P. Keller, Candice N. Baker, Margaret Gaca, Anuj Srivastava, Isabela Gerdes Gyuricza, Madeleine J. Braun, Nadia A. Rosenthal, Alan D. Attie, Gary A. Churchill, Gregory W. Carter   +11 more
doaj   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Jackson with crew

, 1988
Bob Calo and KQED-TV crew interviewing Jackson in the courtyard of his home in La Cienega, NM for the film, "J.B. Jackson and the Love of Everyday Places". Jackson and Calo sit at a picnic table.
Jackson, John Brinckerhoff, 1909-1996
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