Results 181 to 190 of about 3,220,053 (338)

Granulomatosis with Polyangiitis Presenting with Hepatic Involvement. [PDF]

Cureus
Poudel A, Adhikari P, Sundaresan V, Jackson E, Iskander B.   +4 more
europepmc   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

From Sandhurst to scrubs: Military leadership lessons for healthcare. [PDF]

Future Healthc J
Jackson TAD.
europepmc   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

The effects of inanition and malnutrition upon growth and structure, by C. M. Jackson ... 117 illustrations.

C. M. Jackson
semanticscholar   +1 more source

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 *

Allergy. European Journal of Allergy and Clinical Immunology, 2008
J. Bousquet, N. Khaltaev, Á. Cruz, J. Denburg, W. Fokkens, A. Togias, T. Zuberbier, C. Baena-Cagnani, G. Canonica, C. van Weel, I. Agache, N. Aït-Khaled, C. Bachert, M. Blaiss, S. Bonini, L. Boulet, P. Bousquet, P. Camargos, K. Carlsen, Y. Chen, A. Custovic, R. Dahl, P. Demoly, H. Douagui, S. Durham, R. V. van Wijk, O. Kalayci, M. Kaliner, Y-Y. Kim, M. Kowalski, P. Kuna, L. Le, C. Lemière, J. Li, R. Lockey, S. Mavale-Manuel, E. Meltzer, Y. Mohammad, J. Mullol, R. Naclerio, R. O'Hehir, K. Ohta, S. Ouédraogo, S. Palkonen, N. Papadopoulos, G. Passalacqua, R. Pawankar, T. Popov, K. Rabe, J. Rosado-Pinto, G. Scadding, F. Simons, E. Toskala, E. Valovirta, P. V. van Cauwenberge, D-Y Wang, M. Wickman, B. Yawn, A. Yorgancioglu, O. Yusuf, H. Zar, I. Annesi-Maesano, E. Bateman, A. B. Kheder, D. Boakye, J. Bouchard, P. Burney, W. Busse, M. Chan-Yeung, N. Chavannes, A. Chuchalin, W. Dolen, R. Ėmužytė, L. Grouse, M. Humbert, C. Jackson, S. Johnston, P. Keith, J. Kemp, J. Klossek, D. Larenas-Linnemann, B. Lipworth, J. Malo, G. Marshall, C. Naspitz, K. Nékám, B. Niggemann, E. Nizankowska-Mogilnicka, Y. Okamoto, M. Orru, P. Potter, D. Price, S. Stoloff, O. Vandenplas, G. Viegi, D. Williams   +95 more
semanticscholar   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis

Advanced Science, EarlyView.
Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao, Shan Xu, You Zou, Rui Yang, Han Zheng, Jia‐Yu Liu, Hui‐Ming Fan, Yuan‐Yuan Zhang, Yong‐Gang Kong, Wo‐Er Jiao, Shi‐Ming Chen   +10 more
wiley   +1 more source

A case report of an interventricular septal hematoma presenting as a STEMI post-pacemaker implantation

HeartRhythm Case Reports
Diva Maraj, MD, Garima Gandotra, MD, Muhammad Ahmad Qureshi, MD, Iman El-Feki, MD, Omair Ahmed, MD, Hussein Othman, MD, Mumtaz Memon, MD   +6 more
doaj   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source