Implementation of the S100 Calcium-Binding Protein B Biomarker in a Clinical Setting: A Retrospective Study of Benefits, Safety, and Effectiveness [PDF]
Neurotrauma Reports, 2022 Recent years have seen the emergence of the S100 calcium-binding protein B (S100B) biomarker used in the initial management of minor traumatic brain injury (TBI) patients.
Johannes Bech Steinm?ller +4 more
doaj +2 more sources
Temporal trends of hypertrophic cardiomyopathy in Denmark: a nationwide retrospective cohort study [PDF]
BMJ Open, 2023 Objectives To describe the population of patients diagnosed with hypertrophic cardiomyopathy (HCM) in Denmark and determine temporal trends in incidence and patient characteristics over time.Design Nationwide retrospective cohort study.Setting Danish ...
Anne-Marie Schjerning +9 more
doaj +2 more sources
Analysis of antibiotic use patterns in Danish hospitals 2015–2021 using an adapted version of the who aware classification [PDF]
BMJ Open Quality, 2022 Background AWaRe is a tool to categorise and guide antibiotic use. Antibiotics are classified in three groups: Access, Watch and Reserve. The Access group contains first choice antibiotics for 25 of the most common infections.
Jacob Anhøj +6 more
doaj +2 more sources
Characteristics of specialists treating hypothyroid patients: the “THESIS” collaborative [PDF]
Frontiers in Endocrinology, 2023 IntroductionThyroid specialists influence how hypothyroid patients are treated, including patients managed in primary care. Given that physician characteristics influence patient care, this study aimed to explore thyroid specialist profiles and ...
Miloš Žarković +66 more
doaj +2 more sources
Necessity of Prophylactic Extrapleural Chest Tube During Primary Surgical Repair of Esophageal Atresia: A Systematic Review and Meta-Analysis [PDF]
Frontiers in Pediatrics, 2022 BackgroundEsophageal atresia is corrected surgically by anastomosing and recreating esophageal continuity. To allow the removal of excess fluid and air from the anastomosis, a prophylactic and temporary intraoperative chest tube (IOCT) has traditionally ...
Martin Riis Ladefoged +10 more
doaj +2 more sources
COLAR: open-label clinical study of IL-6 blockade with tocilizumab for the treatment of immune checkpoint inhibitor-induced colitis and arthritis [PDF]
Journal for ImmunoTherapy of Cancer, 2022 Background Immune-related adverse events due to immune checkpoint inhibitors (ICIs) are not always effectively treated using glucocorticoids and it may negatively affect the antitumor efficacy of ICIs.
Ole Haagen Nielsen +12 more
doaj +2 more sources
Acute Experimental Barrier Injury Triggers Ulcerative Colitis–Specific Innate Hyperresponsiveness and Ulcerative Colitis–Type Microbiome Changes in HumansSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background and aims: The trigger hypothesis opens the possibility of anti-flare initiation therapies by stating that ulcerative colitis (UC) flares originate from inadequate responses to acute mucosal injuries.
Jakob Benedict Seidelin +9 more
doaj +2 more sources
Pulmonary Function Deficit and Clinical Associations in Childhood Acute Lymphoblastic Leukaemia Survivors: A National Retrospective ALL-STAR Lungs Cohort Study. [PDF]
Pediatr PulmonolABSTRACT Background Although survival for childhood acute lymphoblastic leukaemia (ALL) has improved, long‐term pulmonary function deficit remains a concern. We aimed to explore the prevalence of pulmonary function deficit and abnormal pulmonary function tests in childhood ALL survivors and clinical associations.
Meyer SIR +9 more
europepmc +2 more sources
The use of thyroid hormones in the treatment of euthyroid patients with treatment-resistant depression. Data from a survey of 5695 European national endocrine professional organization members [PDF]
Frontiers in EndocrinologyPurposeTreatment-resistant depression (TRD) is most commonly defined as depression that has not responded to two different pharmacological agents used for an adequate period of time. We explored the views of European specialists via survey, regarding the
Stephen Ludgate +69 more
doaj +2 more sources
Use of thyroid hormones in euthyroid patients with unexplained fatigue: analyses of aggregate data from European national surveys of professional endocrine society members [PDF]
Frontiers in EndocrinologyBackgroundManaging patients with fatigue is a clinical challenge. Because fatigue is often reported in hypothyroidism, thyroid hormone (TH) therapy may sometimes be incorrectly considered for biochemically euthyroid individuals.
Tomasz Bednarczuk +69 more
doaj +2 more sources