Results 211 to 220 of about 56,162 (258)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Correction to “Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors”

Molecular Oncology, EarlyView.
wiley   +1 more source

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JAK inhibitors for rheumatoid arthritis

Expert Opinion on Investigational Drugs, 2023
JAK (Janus kinase) is a type of non-receptor tyrosine kinase that includes JAK1, JAK2, JAK3, and Tyk2. Currently, there are five JAK inhibitors approved for treating rheumatoid arthritis. These inhibitors vary in their selectivity for different JAK isoforms.This review outlines the mode of actions and the results of Phase III trials of the JAK ...
Satoshi Kubo, Shingo Nakayamada, Yoshiya Tanaka   +2 more
openaire   +2 more sources

An Update on JAK Inhibitors

Current Medicinal Chemistry, 2019
Janus kinases (JAKs) are a family of non-receptor tyrosine kinases, composed by four members, JAK1, JAK2, JAK3 and TYK2. JAKs are involved in different inflammatory and autoimmune diseases, as well as in malignancies, through the activation of the JAK/STAT signalling pathway.
Musumeci, Francesca, Greco, Chiara, Giacchello, Ilaria, Fallacara, Anna Lucia, Ibrahim, Munjed M, Grossi, Giancarlo, Brullo, Chiara, Schenone, Silvia   +7 more
openaire   +3 more sources

Selective JAK Inhibitors

Future Medicinal Chemistry, 2014
Consisting of four members, JAK1, JAK2, JAK3 and TYK2, the JAK kinases have emerged as important targets for proliferative and immune-inflammatory disorders. Recent progress in the discovery of selective inhibitors has been significant, with selective compounds now reported for each isoform.
Brian W, Dymock, Eugene Guorong, Yang, Yuyi, Chu-Farseeva, Lianbin, Yao   +3 more
openaire   +2 more sources

JAK inhibitors and black box warnings: what is the future for JAK inhibitors?

Expert Review of Clinical Immunology, 2023
Janus kinase inhibitors (JAKi) have dramatically improved the treatment of various autoimmune and myeloproliferative disorders. Recently, concern has arisen regarding their safety in patients with rheumatoid arthritis.Here, we provide a comprehensive summary of the major current and emerging JAKi and their indications, address recent studies on ...
Kate Tokareva, Pankti Reid, Victor Yang, David Liew, Alexander C. Peterson, Aaron Baraff, Jon Giles, Namrata Singh   +7 more
openaire   +2 more sources

JAK Inhibitors in the Treatment of Lichen Planopilaris

Skin Appendage Disorders, 2023
<b><i>Background:</i></b> Lichen planopilaris (LPP) is an autoimmune disorder leading to lymphocytic cicatricial alopecia. Different agents such as hydroxychloroquine, methotrexate, cyclosporine, and mycophenolate mofetil have been tried to control hair loss with limited efficacy. JAK inhibitors are immune-modulating drugs which
Maryam, Nasimi, Mahshid Sadat, Ansari
openaire   +2 more sources

JAK inhibitors in dermatology

Indian Journal of Skin Allergy, 2023
The four Janus Kinase (JAK) proteins and seven signal transducer and activator of transcription (STAT) factors mediate the intracellular signaling pathway of cytokine receptors, which are described in the pathogenesis of many autoimmune, allergic, and inflammatory dermatoses.
S. K. Shahriar Ahmed, Abhishek De, Aarti Sarda, Kiran Godse, Sandipan Dhar   +4 more
openaire   +1 more source

JAK inhibitors for the treatment of vitiligo

Journal of Dermatological Science
Vitiligo is an autoimmune disease involving melanocyte-targeting T cells initiated by environmental and genetic factors. Steroids and tacrolimus have been used as topical treatments. Recently, novel topical agents targeting Janus kinase (JAK), a family of tyrosine kinases that regulates cytokine signaling, have emerged.
Shintaro, Inoue, Tamio, Suzuki, Shigetoshi, Sano, Ichiro, Katayama   +3 more
openaire   +2 more sources