Results 1 to 10 of about 162,032 (131)
Roles of non-receptor tyrosine kinases in pathogenesis and treatment of depression [PDF]
Journal of Integrative Neuroscience, 2022 Major depressive disorder is a chronic psychiatric disease with a high prevalence. Brain mechanisms for depression at cellular and molecular levels are far from clear. Increasing evidence from clinical and preclinical studies reveals critical roles of
John Q. Wang +4 more
doaj +1 more source
Platelets, 2023 Platelet transfusion refractoriness (PTR) is an intractable issue in hematological patients, which increases bleeding risks and hospitalization costs to a great extent.
Xiaofei Song +6 more
doaj +1 more source
Lysozyme promotes renal fibrosis through the JAK/STAT3 signal pathway in diabetic nephropathy
Archives of Medical Science, 2023 Introduction Diabetic nephropathy (DN) is a leading cause of kidney failure. Lysozyme (LYZ) is an essential component of innate immunity and exhibits antibacterial properties.
Yan Ren +4 more
doaj +1 more source
Platelets, 2022 Several Janus kinase (JAK) inhibitors (jakinibs) have recently been approved to treat inflammatory, autoimmune and hematological conditions. Despite emerging roles for JAKs and downstream signal transducer and activator of transcription (STAT) proteins ...
Iván Parra-Izquierdo +9 more
doaj +1 more source
Pifu-xingbing zhenliaoxue zazhi, 2023 Objective To investigate the effects of β-estradiol (E2) on the phosphorylation of JAK/STAT, PI3K/AKT signaling pathways and the expression of IL-17A in mouse spleen mononuclear cells treated with IL-36β. Methods The spleens were isolated from female SPF
Shuang LIU +7 more
doaj +1 more source
The JAK–STAT pathway in keloid pathogenesis: a systematic review with qualitative synthesis
Experimental Dermatology, Volume 32, Issue 5, Page 588-598, May 2023., 2023 Abstract Keloid tissues contain inflammatory cells and upregulated pro‐inflammatory cytokines. The Janus kinase (JAK)‐signal transducer and activator of transcription (STAT) pathway mediate cellular responses to these cytokines. We performed a systematic review on the role of the JAK–STAT pathway in keloid pathogenesis and the evidence for JAK–STAT ...
Qi Yin +5 more
wiley +1 more source
Diseña, 2018 The world seems more burdened with large-scale global problems than ever before. One such challenge is to reverse the growing incidence of mental health issues, particularly in our cities.
Jak Spencer
doaj +9 more sources
STAT3 and REDD1: an unconventional story of gene repression
The FEBS Journal, Volume 290, Issue 7, Page 1735-1739, April 2023., 2023 Compared with the canonical mechanisms of activating gene expression, the non‐canonical actions of the transcription factor STAT3 have not received much attention. Köhler et al. highlight a novel mechanism of STAT3 repression over the REDD1 gene. These results are essential for understanding the role of the REDD1 protein and the effects of this precise
Pol Garcia‐Segura, Cristina Malagelada
wiley +1 more source
Clinical and Translational Medicine, Volume 12, Issue 8, August 2022., 2022 Activated JAK‐STAT signalling cascade plays a critical role in the onset of therapy‐ and castration‐resistant disease that is associated with stem cell plasticity. IFIT5, a downstream effector of JAK‐STAT signalling pathway, exhibits a new functional role in modulating stemness transcriptional factors (such as BMI1, NANOG and SOX2) by promoting ...
U‐Ging Lo +10 more
wiley +1 more source
eJHaem, Volume 3, Issue 3, Page 764-774, August 2022., 2022 Abstract Inhibitors of the Bromo‐ and Extra‐Terminal domain (BET) family proteins have strong preclinical antitumor activity in multiple tumor models, including lymphomas. Limited single‐agent activity has been reported in the clinical setting. Here, we have performed a pharmacological screening to identify compounds that can increase the antitumor ...
Filippo Spriano +14 more
wiley +1 more source