Results 1 to 10 of about 852,565 (153)

Strongly correlated and topological states in [111] grown transition metal oxide thin films and heterostructures [PDF]

open access: yesAPL Materials, 2020
We highlight recent advances in the theory, materials fabrication, and experimental characterization of strongly correlated and topological states in [111] oriented transition metal oxide thin films and heterostructures, which are notoriously difficult ...
Jak Chakhalian   +2 more
doaj   +4 more sources

Roles of non-receptor tyrosine kinases in pathogenesis and treatment of depression [PDF]

open access: yesJournal of Integrative Neuroscience, 2022
Major depressive disorder is a chronic psychiatric disease with a high prevalence. Brain mechanisms for depression at cellular and molecular levels are far from clear. Increasing evidence from clinical and preclinical studies reveals critical roles of
John Q. Wang   +4 more
doaj   +1 more source

Janus kinase inhibitors ruxolitinib and baricitinib impair glycoprotein-VI mediated platelet function

open access: yesPlatelets, 2022
Several Janus kinase (JAK) inhibitors (jakinibs) have recently been approved to treat inflammatory, autoimmune and hematological conditions. Despite emerging roles for JAKs and downstream signal transducer and activator of transcription (STAT) proteins ...
Iván Parra-Izquierdo   +9 more
doaj   +1 more source

Exploration of risk factors of platelet transfusion refractoriness and its impact on the prognosis of hematopoietic stem cell transplantation: a retrospective study of patients with hematological diseases

open access: yesPlatelets, 2023
Platelet transfusion refractoriness (PTR) is an intractable issue in hematological patients, which increases bleeding risks and hospitalization costs to a great extent.
Xiaofei Song   +6 more
doaj   +1 more source

Lysozyme promotes renal fibrosis through the JAK/STAT3 signal pathway in diabetic nephropathy

open access: yesArchives of Medical Science, 2023
Introduction Diabetic nephropathy (DN) is a leading cause of kidney failure. Lysozyme (LYZ) is an essential component of innate immunity and exhibits antibacterial properties.
Yan Ren   +4 more
doaj   +1 more source

Estradiol inhibits phosphorylation of JAK/STAT, PI3K/AKT and expression of IL-17A in mouse mononuclear cells treated with IL-36β

open access: yesPifu-xingbing zhenliaoxue zazhi, 2023
Objective To investigate the effects of β-estradiol (E2) on the phosphorylation of JAK/STAT, PI3K/AKT signaling pathways and the expression of IL-17A in mouse spleen mononuclear cells treated with IL-36β. Methods The spleens were isolated from female SPF
Shuang LIU   +7 more
doaj   +1 more source

Design for Dynamic Challenges: Key Attributes of Designers for Leading Interdisciplinary Research and Projects

open access: yesDiseña, 2018
The world seems more burdened with large-scale global problems than ever before. One such challenge is to reverse the growing incidence of mental health issues, particularly in our cities.
Jak Spencer
doaj   +9 more sources

JAK3 as an emerging target for topical treatment of inflammatory skin diseases [PDF]

open access: yes, 2016
The recent interest and elucidation of the JAK/STAT signaling pathway created new targets for the treatment of inflammatory skin diseases (ISDs). JAK inhibitors in oral and topical formulations have shown beneficial results in psoriasis and alopecia ...
Alves de Medeiros, Ana   +5 more
core   +2 more sources

Non-commutative deformation of Chern-Simons theory [PDF]

open access: yes, 2020
The problem of the consistent definition of gauge theories living on the non-commutative (NC) spaces with a non-constant NC parameter $\Theta(x)$ is discussed.
Kupriyanov, Vladislav G.
core   +3 more sources

Runx1 promotes the development of glioma cells by regulating JAK-STAT signalling pathway

open access: yesArchives of Medical Science, 2019
Introduction Human glioma is known as the most frequent and primary malignant tumour of the central nervous system with high aggression and poor prognosis.
Yong Zhang, Qiming Xia, Jun Lin
doaj   +1 more source

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