Janus Kinases in Leukemia [PDF]
Cancers, 2021 Simple Summary Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is a crucial cell signaling pathway that drives the development, differentiation, and function of immune cells and has an important role in blood cell ...
Bobin George Abraham, Teemu Haikarainen
exaly +9 more sources
Baricitinib: A 2018 Novel FDA-Approved Small Molecule Inhibiting Janus Kinases [PDF]
Pharmaceuticals, 2019 In 2018, Baricitinib was approved by the Food and Drig Administration (FDA) for the treatment of rheumatoid arthritis. Baricitinib exerts its action by targeting Janus kinases (JAK).
Annie Mayence, Jean Jacques Vanden Eynde
exaly +5 more sources
Targeting of Janus Kinases Limits Pro-Inflammatory but Also Immunosuppressive Circuits in the Crosstalk between Synovial Fibroblasts and Lymphocytes [PDF]
Biomedicines, 2021 Crosstalk between synovial fibroblasts (SF) and immune cells plays a central role in the development of rheumatoid arthritis (RA). Janus kinase inhibitors (JAKi) have proven efficacy in the treatment of RA, although clinical responses are heterogeneous ...
Wolfgang Merkt +2 more
exaly +4 more sources
Parthenolide Inhibits STAT3 Signaling by Covalently Targeting Janus Kinases [PDF]
Molecules, 2018 Aberrant activations of the STAT3 (signal transducer and activator of transcription 3) signaling pathway are associated with cancer and inflammatory diseases.
Man Liu +5 more
doaj +3 more sources
Molecular dissection of Janus kinases as drug targets for inflammatory diseases [PDF]
Frontiers in Immunology, 2022 The Janus kinase (JAK) family enzymes are non-receptor tyrosine kinases that phosphorylate cytokine receptors and signal transducer and activator of transcription (STAT) proteins in the JAK-STAT signaling pathway.
Sunghark Kwon
doaj +2 more sources
In Silico and In Vitro Study of Janus Kinases Inhibitors from Naphthoquinones [PDF]
Molecules, 2023 Janus kinases (JAKs) are involved in numerous cellular signaling processes related to immune cell functions. JAK2 and JAK3 are associated with the pathogenesis of leukemia and common lymphoid-derived illnesses.
Kamonpan Sanachai +8 more
doaj +2 more sources
Revisiting Janus kinases as molecular drug targets for rheumatic diseases [PDF]
Frontiers in MedicineJanus kinase (JAK) family members, as upstream regulators, phosphorylate not only themselves but also cytokine receptors and signal transducer and activator of transcription (STAT) proteins in the JAK-STAT signaling pathway.
Sunghark Kwon, Sunghark Kwon
doaj +2 more sources
Evaluation of immunohistochemical and gene expression of Janus kinase 1 and Janus kinase 3 in the skin of different clinical types of mycosis fungoides patients - Part II: reverse transcriptase-polymerase chain reaction [PDF]
Anais Brasileiros de DermatologiaBackground Mycosis Fungoides (MF) is the commonest type of primary cutaneous T-Cell lymphomas representing about 50% of all lymphomas arising primarily in the skin. Janus kinases are non-receptor intracellular tyrosine kinases that play an important role
Heba Saed El-Amawy +3 more
doaj +3 more sources
Janus kinases restrain chronic lymphocytic leukemia cells in patients on ibrutinib: Results of a phase II trial [PDF]
Cancer Medicine, 2021 David E Spaner
exaly +2 more sources
Evaluation of immunohistochemical and gene expression of Janus kinase 1 and Janus kinase 3 in the skin of different clinical types of mycosis fungoides patients - Part I [PDF]
Anais Brasileiros de DermatologiaBackground Mycosis fungoides is the commonest type of cutaneous T-Cell lymphoma. Janus kinases are intracellular tyrosine kinases that have recently been proven to have a crucial role in the pathogenesis and progression of several dermatological and ...
Heba Saed El-Amawy +3 more
doaj +3 more sources