Janus kinases: dermatological perspective, a review [PDF]
Journal of the Egyptian Women’s Dermatologic Society, 2020 Janus kinases (JAKs) are a group of nonreceptor intracellular tyrosine kinases that could modify cytokine-mediated signals through the JAK-signal transducer and activator of transcription pathway.
Hanan R Nada +3 more
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Basics of Janus kinases: a review [PDF]
Journal of the Egyptian Women’s Dermatologic Society, 2020 Janus kinases (JAKs) are a group of nonreceptor intracellular tyrosine kinases that could modify cytokine-mediated signals through the JAK-signal transducer and activator of transcription (STAT) pathway. The intracellular signaling pathway JAK/STAT has a
Hanan R Nada +3 more
doaj +2 more sources
The Janus kinases (Jaks) [PDF]
Genome Biology, 2004 The Janus kinase (Jak) family is one of ten recognized families of non-receptor tyrosine kinases. Mammals have four members of this family, Jak1, Jak2, Jak3 and Tyrosine kinase 2 (Tyk2). Birds, fish and insects also have Jaks. Each protein has a kinase domain and a catalytically inactive pseudo-kinase domain, and they each bind cytokine receptors ...
Yamaoka, Kunihiro +5 more
openaire +6 more sources
RUSSIAN AND INTERNATIONAL EXPERIENCE IN THE APPLICATION OF THE JANUS-KINASES INHIBITOR IN RHEUMATOID ARTHRITIS [PDF]
Медицинский совет, 2017 The survey provides data on the use of the only currently available representative of the so-called «small molecules» of the Janus-kinases Inhibitor Tofacitinibe (TOFA) in rheumatoid arthritis (RA) in clinical research and real practice. The positioning
D. E. Karateev +2 more
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Tyrosine kinases in rheumatoid arthritis [PDF]
Journal of Inflammation, 2011 Rheumatoid arthritis (RA) is an inflammatory, polyarticular joint disease. A number of cellular responses are involved in the pathogenesis of rheumatoid arthritis, including activation of inflammatory cells and cytokine expression. The cellular responses
Kobayashi Akiko, Okamoto Hiroshi
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Pseudorabies Virus Inhibits Type I and Type III Interferon-Induced Signaling via Proteasomal Degradation of Janus Kinases. [PDF]
J Virol, 2021 Both type I and III interferons (IFNs) play a crucial role in host antiviral response by activating the JAK/STAT (Janus kinase/signal transducer and activator of transcription) signaling pathway to trigger the expression of antiviral IFN-stimulated genes
Yin Y, Romero N, Favoreel HW.
europepmc +2 more sources
Janus kinases restrain chronic lymphocytic leukemia cells in patients on ibrutinib: Results of a phase II trial [PDF]
Cancer Medicine, 2021 David E Spaner
exaly +2 more sources
Janus kinase inhibitors - their current applications and future prospects [PDF]
Farmacja Polska, 2022 Janus kinase inhibitors are a group of drugs that provide an alternative to conventional therapy for numerous diseases. The most studied drug of this group is tofacitinib.
Natalia Wierzbowska +4 more
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Marine Bioactive Molecules as Inhibitors of the Janus Kinases: A Comparative Molecular Docking and Molecular Dynamics Simulation Approach [PDF]
Current Issues in Molecular BiologyEmad A Ahmed +2 more
exaly +2 more sources
Partial repigmentation of vitiligo with tofacitinib, without exposure to ultraviolet radiation, [PDF]
Anais Brasileiros de Dermatologia, 2020 Vitiligo is a disease that causes macules and achromic and/or hypochromic patches, which can affect from small areas to the entire tegument. Treatment options are few and are generally ineffective.
Melpone Komnitski +3 more
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