Marine Bioactive Molecules as Inhibitors of the Janus Kinases: A Comparative Molecular Docking and Molecular Dynamics Simulation Approach [PDF]
Current Issues in Molecular BiologyEmad A Ahmed, Salaheldin Abdelsalam
exaly +2 more sources
Identification of the protein kinases Pyk3 and Phg2 as regulators of the STATc-mediated response to hyperosmolarity [PDF]
, 2014 Cellular adaptation to changes in environmental osmolarity is crucial for cell survival. In Dictyostelium, STATc is a key regulator of the transcriptional response to hyperosmotic stress. Its phosphorylation and consequent activation is controlled by two
A Kortholt +37 more
core +15 more sources
Partial repigmentation of vitiligo with tofacitinib, without exposure to ultraviolet radiation, [PDF]
Anais Brasileiros de Dermatologia, 2020 Vitiligo is a disease that causes macules and achromic and/or hypochromic patches, which can affect from small areas to the entire tegument. Treatment options are few and are generally ineffective.
Melpone Komnitski +3 more
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Insights into the Binding Recognition and Susceptibility of Tofacitinib toward Janus Kinases [PDF]
ACS Omega, 2020 Kamonpan Sanachai +5 more
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Janus kinase (JAK) inhibitors in the treatment of neoplastic and inflammatory disorders
Pharmacological Research, 2022 The Janus kinase (JAK) family of nonreceptor protein-tyrosine kinases consists of JAK1, JAK2, JAK3, and TYK2 (Tyrosine Kinase 2). Each of these proteins contains a JAK homology pseudokinase (JH2) domain that interacts with and regulates the activity of ...
Robert Roskoski, Jr.
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The Janus kinases (Jaks) [PDF]
Genome Biology, 2004 The Janus kinase (Jak) family is one of ten recognized families of non-receptor tyrosine kinases. Mammals have four members of this family, Jak1, Jak2, Jak3 and Tyrosine kinase 2 (Tyk2). Birds, fish and insects also have Jaks. Each protein has a kinase domain and a catalytically inactive pseudo-kinase domain, and they each bind cytokine receptors ...
Yamaoka, Kunihiro +5 more
openaire +3 more sources
New Applications of JAK/STAT Inhibitors in Pediatrics: Current Use of Ruxolitinib
Pharmaceuticals, 2022 Janus kinases (JAK) are a family of tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) that transduce cytokine-mediated signals through the JAK–STAT metabolic pathway.
Annalisa Marcuzzi +6 more
doaj +1 more source
Janus kinases: dermatological perspective, a review
Journal of the Egyptian Women’s Dermatologic Society, 2020 Janus kinases (JAKs) are a group of nonreceptor intracellular tyrosine kinases that could modify cytokine-mediated signals through the JAK-signal transducer and activator of transcription pathway.
Hanan R Nada +3 more
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Pharmaceuticals, 2022 Systemic sclerosis and systemic lupus erythematosus represent two distinct autoimmune diseases belonging to the group of connective tissue disorders.
Przemysław Kotyla +3 more
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Basics of Janus kinases: a review
Journal of the Egyptian Women’s Dermatologic Society, 2020 Janus kinases (JAKs) are a group of nonreceptor intracellular tyrosine kinases that could modify cytokine-mediated signals through the JAK-signal transducer and activator of transcription (STAT) pathway. The intracellular signaling pathway JAK/STAT has a
Hanan R Nada +3 more
doaj +1 more source