-escin mitigates neuroinflammation and apoptosis caused by ischemic stroke through the inhibition of the interleukin-6/Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway [PDF]
Journal of International Medical ResearchObjective This study aimed to investigate the protective effects of β-escin against neuroinflammatory injury and its influence on the interleukin-6/Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway in a rat model of ...
Duan Yanqin +9 more
doaj +2 more sources
Signal Transducer and Activator of Transcription 4 (STAT4) Association with Pituitary Adenoma [PDF]
MedicinaBackground/Objectives: This study aims to investigate whether Signal Transducer and Activator of Transcription 4 (STAT4) influences the anti-tumor immune response and is possibly involved in the initiation or relapse of pituitary adenomas (PAs) by ...
Greta Gedvilaite-Vaicechauskiene +2 more
doaj +2 more sources
Impaired natural killer cell functions in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations [PDF]
Journal of Allergy and Clinical Immunology, 2017 Gain-of-function (GOF) mutations affecting the coiled-coil domain or the DNA-binding domain of signal transducer and activator of transcription 1 (STAT1) cause chronic mucocutaneous candidiasis disease.
Giovanna Tabellini +2 more
exaly +2 more sources
Signal Transducer and Activator of Transcription Proteins at the Nexus of Immunodeficiency, Autoimmunity and Cancer [PDF]
Biomedicines, 2023 The signal transducer and activator of transcription (STAT) family of proteins has been demonstrated to perform pivotal roles downstream of a myriad of cytokines, particularly those that control immune cell production and function. This is highlighted by
Clifford Liongue +2 more
doaj +2 more sources
A Rare Mesenchymal Neoplasm at an Uncommon Anatomical Site- Solitary Fibrous Tumour of Vulva [PDF]
Journal of Clinical and Diagnostic Research, 2022 Previously, Solitary Fibrous Tumour (SFT) was thought to originate from the pleura, a relatively rare mesenchymal neoplasm with an indolent course. Vulva is a very uncommon site of extrathoracic SFT. This is a report of a very uncommon case of vulval SFT
Nupur Kaushik +3 more
doaj +1 more source
NT157 Inhibits HCC Migration via Downregulating the STAT3/Jab1 Signaling Pathway
Technology in Cancer Research & Treatment, 2021 Purpose: The high fatality-to-case ratio of hepatocellular carcinoma is directly related to metastasis. The signal transducer and activator of transcription-3 is a key mediator of the cytokine and growth factor signaling pathways and drives the ...
SiZhe Yu +7 more
doaj +1 more source
Clinicopathological significance of protein disulphide isomerase A3 and phosphorylated signal transducer and activator of transcription 3 in cervical carcinoma [PDF]
Contemporary OncologyAsmaa Abdullatif +7 more
doaj +2 more sources
Signal transducer and activator of transcription 3 [PDF]
Current Opinion in Hematology, 2016 Signal transducer and activator of transcription 3 (STAT3) is an important transcription factor involved in a wide variety of cellular functions. Germline loss-of-function mutations are known to cause hyper-IgE immunodeficiency (autosomal dominant hyper IgE syndrome), whereas somatic gain-of-function mutations have been described in large granular cell
Lisa R, Forbes +2 more
openaire +3 more sources
Special Issue “Role of STAT3 in Oncogenesis”
Biomedicines, 2022 This Biomedicines Special Issue was designed to attract articles that focused on the pleiotropic role of the signal transducer and activator of transcription 3 (STAT3) transcription factor in different facets of tumorigenesis [...]
Kwang Seok Ahn
doaj +1 more source
JID Innovations, 2021 The emergence of a common progenitor cell has been postulated for the association of CD30-positive lymphoproliferative disease (LPD) and mycosis fungoides (MF) within the same patient.
Marion Wobser +7 more
doaj +1 more source