Results 31 to 40 of about 110,595 (300)

Signal transducer and activator of transcription-1 localizes to the mitochondria and modulates mitophagy [PDF]

, 2013
The signal transducer and activator of transcription (STAT) proteins are latent transcription factors that have been shown to be involved in cell proliferation, development, apoptosis, and autophagy. STAT proteins undergo activation by phosphorylation at
Stephanou, A., McCormick, J., Latchman, David S., Knight, R,A,, Bourke, L.T.   +4 more
core   +1 more source

STAT3 (signal transducer and activator of transcription 3)

, 2004
Review on STAT3 (signal transducer and activator of transcription 3), with data on DNA, on the protein encoded, and where the gene is ...
Cochran, BH
core   +1 more source

Targeting Signal Transducer and Activator of Transcription Signaling Pathway in Leukemias [PDF]

Journal of Clinical Oncology, 2009
Signal transducer and activator of transcription (STAT) proteins comprise a seven-member family of latent cytoplasmic transcription factors that are activated through tyrosine phosphorylation by a variety of cytokines and growth factors. Aberrant activation of STATs accompanies malignant cellular transformation with resultant leukemogenesis ...
Wetzler, Meir, Baumann, Heinz, Benekli, Mustafa   +2 more
openaire   +3 more sources

The role of signal transducer and activator of transcription-3 (STAT-3) in ischaemic and pharmacological postconditioning [PDF]

, 2011
Includes abstract. Includes bibliographical references (leaves 131-147)
Somers, Sarin J
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Interferon-alpha resistance in renal carcinoma cells is associated with defective induction of signal transducer and activator of transcription 1 which can be restored by a supernatant of phorbol 12-myristate 13-acetate stimulated peripheral blood mononuclear cells

, 2022
S.449-455Therapy of selected human malignancies with interferon-alpha is widely accepted but often complicated by the emergence of interferon-alpha resistance.
Patzelt, T., Atzpodien, J., Jakschies, D., Bernier, T., Dallmann, I., Emmendörffer, A., Grosse, J., Brinckmann, A., Axer, S.   +8 more
core   +1 more source

ABL1-STAT3-NLRP3 axis attenuates pyroptosis and alleviates diabetic retinopathy

Electronic Journal of Biotechnology
Background: Diabetic retinopathy is a major microvascular complication of diabetes and a leading cause of vision loss. Persistent low-grade inflammation drives disease progression.
Lili Hu, Gong Chen, Haoning Pan, Shaoxin Pan   +3 more
doaj   +1 more source

Activation of signal-transducer and activator of transcription 1 (STAT1) in pouchitis [PDF]

Clinical and Experimental Immunology, 2001
Summary Activation of signal transducer and activator of transcription 1 (STAT1) is a hallmark of IFN-γ receptor signal transduction but is also part of the signalling pathway of other cytokines/growth factor receptors. In ulcerative colitis, high levels of activation and expression of STAT1 have been observed in comparison with both ...
T, Kühbacher, P, Gionchetti, J, Hampe, U, Helwig, P, Rosenstiel, M, Campieri, H J, Buhr, S, Schreiber   +7 more
openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Extracellular signal-regulated kinase mitogen-activated protein kinase-dependent SOCS-3 gene induction requires c-Jun, signal transducer and activator of transcription 3, and specificity protein 3 transcription factors

, 2012
SOCS-3 gene induction by cAMP-elevating agents or the protein kinase C (PKC) activator, phorbol 12-myristate 13-acetate (PMA), in primary HUVECs was found to require PKCη- and PKCε-dependent extracellular signal-regulated kinase (ERK) activation.
Dunlop, Julia, Yarwood, Stephen J; id_orcid, Borland, Gillian, Gao, Shan, Yarwood, Stephen J., Wiejak, Jolanta   +5 more
core   +1 more source