Results 41 to 50 of about 152,319 (301)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

STAT3 gain-of-function mutation in a patient with pulmonary Mycobacterium abscessus infection

Respiratory Medicine Case Reports, 2020
Background: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor involved in cellular proliferation, apoptosis, and differentiation.
Miguel S. Gonzalez-Mancera, Britt Johnson, Mehdi Mirsaeidi   +2 more
doaj   +1 more source

Single-cell RNA sequencing combined with whole exome sequencing reveals the landscape of the immune pathogenic response to chronic mucocutaneous candidiasis with STAT1 GOF mutation

Frontiers in Immunology, 2022
Chronic mucocutaneous candidiasis (CMC) is characterized by recurrent or persistent infections with Candida of the skin, nails, and mucous membranes (e.g., mouth, esophagus, and vagina).
Xiaodi Lu, Keming Zhang, Weiwei Jiang, Weiwei Jiang, Hang Li, Yue Huang, Mingwei Du, Jian Wan, Yanyun Cao, Yanyun Cao, Lin Du, Xiaogang Liu, Weihua Pan   +12 more
doaj   +1 more source

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]

, 2009
Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Signal Transducer and Activator of Transcription 3 Mutation with Invasive Eosinophilic Disease

Allergy & Rhinology, 2012
Hyper-IgE syndrome (HIES), or Jobs disease, is a rare immunologic disorder characterized by the triad of staphylococcal abscesses, pneumonia with pneumatocele formation, and elevated IgE. It has been shown to have multiple modes of inheritance, autosomal
Kara Crosby D.O., David Swender D.O., Leah Chernin D.O., Said Hafez-Khayyata, Hans Ochs M.D., Haig Tcheurekdjian M.D., Robert Hostoffer D.O.   +6 more
doaj   +1 more source

Expression Levels of Predominant Adipokines and Activations of STAT3, STAT6 in an Experimental Mice Model of Obese Asthma

Iranian Journal of Allergy, Asthma and Immunology, 2019
Obese asthma is a new asthma phenotype. The underlying mechanisms are not clearly understood. Leptin and adiponectin are two predominant adipokines produced by adipose tissue.
Lei Chong, Liu Liu, Lili Zhu, Haiyan Li, Youyou Shao, Hailin Zhang, Gang Yu   +6 more
doaj   +1 more source

Definition of a family of tissue-protective cytokines using functional cluster analysis: a proof-of-concept study [PDF]

, 2014
The discovery of the tissue-protective activities of erythropoietin (EPO) has underlined the importance of some cytokines in tissue-protection, repair, and remodeling.
Annenkov, Alexander, Ermilov, Peter, Ghezzi, Pietro, Mengozzi, Manuela, Pearl, Frances   +4 more
core   +3 more sources

Signal Transducer and Activator of Transcription 4 in Liver Diseases [PDF]

International Journal of Biological Sciences, 2015
STAT4 is a member of the signal transducer and activator of transcription (STAT) family of molecules that localizes to the cytoplasm. STAT4 regulates various genes expression as a transcription factor after it is phosphorylated, dimerizes and translocates to the nucleus.
Wang, Yan, Qu, Aijuan, Wang, Hua
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source