Results 41 to 50 of about 110,595 (300)

Dengue virus inhibits alpha interferon signaling by reducing STAT2 expression [PDF]

, 2005
Type 1 interferons (IFN-?/?) are key mediators of innate antiviral responses but havelittle effect on established replication of dengue viruses, which are mosquito-borneflaviviruses of immense global health importance.
Jones, M, Jacobs, M, Ball, S, Hibbert, L, Foster, G, Davidson, AD, Foster, GR, Davidson, A, Gruenwald, P, Schlaak, J   +9 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Supplementary Data from Bortezomib up-regulates activated signal transducer and activator of transcription-3 and synergizes with inhibitors of signal transducer and activator of transcription-3 to promote head and neck squamous cell carcinoma cell death

, 2009
Supplementary Data from Bortezomib up-regulates activated signal transducer and activator of transcription-3 and synergizes with inhibitors of signal transducer and activator of transcription-3 to promote head and neck squamous cell carcinoma cell ...
Yan Zang (2977992), David SK. Man (15042410), Jennifer R. Grandis (505756), Daniel E. Johnson (8269395), Changyou Li (546820), Rebecca J. Leeman-Neill (15042407), Malabika Sen (505755)   +6 more
core   +1 more source

Signal Transducer and Activator of Transcription 3 Mutation with Invasive Eosinophilic Disease

Allergy & Rhinology, 2012
Hyper-IgE syndrome (HIES), or Jobs disease, is a rare immunologic disorder characterized by the triad of staphylococcal abscesses, pneumonia with pneumatocele formation, and elevated IgE. It has been shown to have multiple modes of inheritance, autosomal
Kara Crosby D.O., David Swender D.O., Leah Chernin D.O., Said Hafez-Khayyata, Hans Ochs M.D., Haig Tcheurekdjian M.D., Robert Hostoffer D.O.   +6 more
doaj   +1 more source

Expression Levels of Predominant Adipokines and Activations of STAT3, STAT6 in an Experimental Mice Model of Obese Asthma

Iranian Journal of Allergy, Asthma and Immunology, 2019
Obese asthma is a new asthma phenotype. The underlying mechanisms are not clearly understood. Leptin and adiponectin are two predominant adipokines produced by adipose tissue.
Lei Chong, Liu Liu, Lili Zhu, Haiyan Li, Youyou Shao, Hailin Zhang, Gang Yu   +6 more
doaj   +1 more source

Single-cell RNA sequencing combined with whole exome sequencing reveals the landscape of the immune pathogenic response to chronic mucocutaneous candidiasis with STAT1 GOF mutation

Frontiers in Immunology, 2022
Chronic mucocutaneous candidiasis (CMC) is characterized by recurrent or persistent infections with Candida of the skin, nails, and mucous membranes (e.g., mouth, esophagus, and vagina).
Xiaodi Lu, Keming Zhang, Weiwei Jiang, Weiwei Jiang, Hang Li, Yue Huang, Mingwei Du, Jian Wan, Yanyun Cao, Yanyun Cao, Lin Du, Xiaogang Liu, Weihua Pan   +12 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

STK11 Prevents Invasion through Signal Transducer and Activator of Transcription 3/5 and FAK Repression in Cutaneous Melanoma

, 2022
The STK11/LKB1 is a tumor suppressor involved in metabolism and cell motility. In BRAF$^{V600E}$ melanoma, STK11 is inactivated by extracellular signal‒regulated kinase and RSK, preventing it from binding and activating adenosine monophosphate-activated ...
Tiso, Natascia, Lyck, Ruth, Dummer, Reinhard; https://orcid.org/, Dzung, Andreas; https://orcid.org/, Saltari, Annalisa, Levesque, Mitchell P; https://orcid.org/   +5 more
core   +1 more source

Infection-stimulated Anemia Results Primarily from Interferon Gamma-dependent, Signal Transducer and Activator of Transcription 1-independent Red Cell Loss

Chinese Medical Journal, 2015
Background: Although the onset of anemia during infectious disease is commonly correlated with production of inflammatory cytokines, the mechanisms by which cytokines induce anemia are poorly defined.
Zheng Wang, Dong-Xia Zhang, Qi Zhao
doaj   +1 more source