Targeting STAT-3 signaling pathway in cancer for development of novel drugs: Advancements and challenges [PDF]
Genetics and Molecular Biology, 2020 Signal transducers and activators of transcription 3 (STAT-3) is a transcription factor that regulates the gene expression of several target genes. These factors are activated by the binding of cytokines and growth factors with STAT-3 specific receptors ...
Sundas Arshad +6 more
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Targeting Canonical and Non-Canonical STAT Signaling Pathways in Renal Diseases
Cells, 2021 Signal transducer and activator of transcription (STAT) plays an essential role in the inflammatory reaction and immune response of numerous renal diseases.
Lili Gai +3 more
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STAT proteins: a kaleidoscope of canonical and non-canonical functions in immunity and cancer
Journal of Hematology & Oncology, 2021 STAT proteins represent an important family of evolutionarily conserved transcription factors that play key roles in diverse biological processes, notably including blood and immune cell development and function.
Nagendra Awasthi +2 more
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Interactions of the Nipah Virus P, V, and W Proteins across the STAT Family of Transcription Factors
mSphere, 2020 The Nipah virus (NiV) phosphoprotein (P) gene encodes four proteins. Three of these—P, V, and W—possess a common N-terminal domain but distinct C termini. These proteins interact with immune modulators. Previous studies demonstrated that P, V, and W bind
Timothy R. Keiffer +3 more
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Research progress on the role of STAT in the pathogenesis of dermatosis [PDF]
Jichu yixue yu linchuang, 2021 Signal transducer and activator of transcription (STAT) proteins with transcriptional activity, which are involved in the pathogenesis and formation of skin lesions of atopic dermatitis, psoriasis, skin tumors and other dermatosis, and are related to the
ZHOU Qiong-yan, LIN Wei, XU Su-ling, ZHAO Ke-yu
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STAT proteins in cancerogenesis and therapy of malignancies [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2009 Signal transducers and activators of transcription (STAT) proteins are a 7-member family of cytoplasmic transcription fators that participate in signal transduction by cytokines, hormones, and growth factors.
Konjević Gordana
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Multi-Source Pathways of T Follicular Helper Cell Differentiation
Frontiers in Immunology, 2021 T follicular helper (Tfh) cells participate in humoral immune by promoting inflammation and aiding B cells survival, proliferation, maturation, and generation autoantibodies.
Xiaoxue Ma +5 more
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Factors increasing the risk of mortality and morbidity due to coronavirus infection in patients with metabolic syndrome [PDF]
Precision and Future Medicine, 2020 Patients living with comorbid metabolic syndrome (MS) and metabolic disorders such as obesity and type 2 diabetes mellitus carry increased levels of circulating cytokines and systemic low-grade inflammation.
Altansuvd Enkhtur +2 more
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JAK/STAT and Hox Dynamic Interactions in an Organogenetic Gene Cascade. [PDF]
PLoS Genetics, 2015 Organogenesis is controlled by gene networks activated by upstream selector genes. During development the gene network is activated stepwise, with a sequential deployment of successive transcription factors and signalling molecules that modify the ...
Pedro B Pinto +3 more
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Suppression of Autoimmune Arthritis by Small Molecule Inhibitors of the JAK/STAT Pathway
Pharmaceuticals, 2010 A skewed ratio of pro-inflammatory to anti-inflammatory cytokines, elevated growth factor synthesis and T- and B-lymphocyte activation are 3 hallmarks of rheumatoid arthritis (RA) pathology.
Charles J. Malemud
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