Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity. [PDF]
Immunity, 2015 Interleukin-6 (IL-6) and IL-27 signal through a shared receptor subunit and employ the same downstream STAT transcription proteins, but yet are ascribed unique and overlapping functions. To evaluate the specificity and redundancy for these cytokines, we quantified their global transcriptomic changes and determined the relative contributions of STAT1 ...
Hirahara K +19 more
europepmc +6 more sources
Activation of STAT transcription factors by the Rho-family GTPases. [PDF]
Biochem Soc Trans, 2020 The Rho-family of small GTPases are biological molecular switches that are best known for their regulation of the actin cytoskeleton. Through their activation and stimulation of downstream effectors, the Rho-family control pathways involved in cellular morphology, which are commonly activated in cancer cell invasion and metastasis.
Corry J, Mott HR, Owen D.
europepmc +4 more sources
JAK/STAT and Hox Dynamic Interactions in an Organogenetic Gene Cascade. [PDF]
PLoS Genetics, 2015 Organogenesis is controlled by gene networks activated by upstream selector genes. During development the gene network is activated stepwise, with a sequential deployment of successive transcription factors and signalling molecules that modify the ...
Pedro B Pinto +3 more
doaj +5 more sources
DLK orchestrates a modular transcriptional response to axon injury with separate roles for Fos and Jun. [PDF]
PLoS GeneticsAxon injury initiates transcriptional reprogramming that in competent cells leads to regeneration. In vertebrate neurons, DLK acts upstream of Jun, STAT and Atf3, core transcription factors that mediate regeneration.
Gibarni Mahata +3 more
doaj +2 more sources
Rare mutations provide unique insight into oncogenic potential of STAT transcription factors. [PDF]
J Clin Invest, 2018 The inappropriate activation of transcription factors, including STATs, is known to promote tumor initiation and progression. The most common mechanisms of misregulation lead to constitutive activation of WT STATs. However, the recent discovery of rare STAT mutations in hematopoietic malignancies suggests that STAT mutants may be oncogenic.
Heppler LN, Frank DA.
europepmc +4 more sources
Targeting STAT-3 signaling pathway in cancer for development of novel drugs: Advancements and challenges [PDF]
Genetics and Molecular Biology, 2020 Signal transducers and activators of transcription 3 (STAT-3) is a transcription factor that regulates the gene expression of several target genes. These factors are activated by the binding of cytokines and growth factors with STAT-3 specific receptors ...
Sundas Arshad +6 more
doaj +1 more source
Activated Stat Related Transcription Factors in Acute Leukemia [PDF]
Leukemia & Lymphoma, 1997 Cell proliferation and differentiation are under the control of cytokines and growth factors. Different signaling pathways are involved in the transmission of a specific signal through successive phosphorylation and dephosphorylation of proteins leading to gene transcription necessary for growth and differentiation.
Gouilleux-Gruart, Valérie +6 more
openaire +2 more sources
Targeting Canonical and Non-Canonical STAT Signaling Pathways in Renal Diseases
Cells, 2021 Signal transducer and activator of transcription (STAT) plays an essential role in the inflammatory reaction and immune response of numerous renal diseases.
Lili Gai +3 more
doaj +1 more source
Ready, STAT, go: transcription factors on the move [PDF]
The EMBO Journal, 2012 Recovery from peripheral nerve injury can be relatively successful, but the insult can also lead to permanent neurological deficits including failure of reinnervation and neuronal loss. What determines whether a neuron survives and regenerates after injury? The existence of injury signals ascending from the axon to the cell body was proposed to account
DI LIBERTO, Valentina, Cavalli, V.
openaire +3 more sources
STAT proteins: a kaleidoscope of canonical and non-canonical functions in immunity and cancer
Journal of Hematology & Oncology, 2021 STAT proteins represent an important family of evolutionarily conserved transcription factors that play key roles in diverse biological processes, notably including blood and immune cell development and function.
Nagendra Awasthi +2 more
doaj +1 more source