Results 41 to 50 of about 207,076 (296)

Evolutionary, comparative, and functional analyses of STATs and regulation of the JAK-STAT pathway in lumpfish upon bacterial and poly(I:C) exposure

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundThe Janus kinase/signal transducers and activators of transcription (JAK-STAT) system regulates several biological processes by affecting transcription of genes as a response to cytokines and growth factors.
Shreesha S. Rao, Patrick A. Nelson, Harald S. Lunde, Gyri T. Haugland   +3 more
doaj   +1 more source

HIV-1 gp120 influences the expression of microRNAs in human monocyte-derived dendritic cells via STAT3 activation [PDF]

, 2015
Background: MicroRNAs (miRs) are an abundant class of small non-coding RNAs (~22 nt) that reprogram gene ex- pression by targeting mRNA degradation and translational disruption.
Da Sacco, Letizia, Del Cornò, Manuela, DONNINELLI, GLORIA, Gessani, Sandra, Masotti, Andrea, Varano, Barbara   +5 more
core   +1 more source

Genomics analysis on the responses of E. coli cells to varying environmental conditions [PDF]

, 2016
The natural living environments of E. coli cells are diverse, varying from mammalian gastrointestinal tracts and soil. Each environment might require distinct metabolic pathways and transporter systems, and long-term evolution has established elaborate ...
Yan, Xiwei
core   +1 more source

Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission [PDF]

, 2015
Defects of mitochondrial dynamics are emerging causes of neurological disease. In two children presenting with severe neurological deterioration following viral infection we identified a novel homozygous STAT2 mutation, c.1836C4A (p.Cys612Ter), using ...
Anderson, G, Cale, CM, Chalasani, A, Chan, E, Duchen, MR, Gilmour, KC, Hambleton, S, Jacques, S, Osellame, LD, Plagnol, V, Qasim, W, Rahman, S, Shahni, R, Taanman, JW, Wadatilake, Y   +14 more
core   +1 more source

Epigenetic signals that direct cell type–specific interferon beta response in mouse cells

Life Science Alliance, 2023
Preexisting cell type–specific chromatin features represent an additional regulatory layer for interferon beta response and direct binding of STAT transcription factors and gene induction. The antiviral response induced by type I interferon (IFN) via the
Markus Muckenhuber, Isabelle Seufert, Katharina Müller-Ott, Jan-Philipp Mallm, Lara C Klett, Caroline Knotz, Jana Hechler, Nick Kepper, Fabian Erdel, Karsten Rippe   +9 more
doaj   +1 more source

MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3 [PDF]

, 2016
The ubiquitin ligase MDM2 is best known for balancing the activity of the tumor suppressor p53. We have previously shown that MDM2 is vital for adipocyte conversion through controlling Cebpd expression in a p53-independent manner.
Barrio-Hernandez, I, Blagoev, B, Grøntved, L, Hallenborg, P, Kristiansen, K, Mandrup, S, Nielsen, R, Siersbæk, M   +7 more
core   +3 more sources

Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication

Frontiers in Oncology, 2019
Signal Transducer and Activator of Transcription (STAT) pathway is connected upstream with Janus kinases (JAK) family protein and capable of integrating inputs from different signaling pathways.
Chin-Yap Loh, Aditya Arya, Ahmed Fadhil Naema, Won Fen Wong, Gautam Sethi, Chung Yeng Looi   +5 more
doaj   +1 more source

Double-edged sword of JAK/STAT signaling pathway in viral infections: novel insights into virotherapy

Cell Communication and Signaling, 2023
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) is an intricate signaling cascade composed of various cytokines, interferons (IFN, growth factors, and other molecules.
Mohamad Mahjoor, Golnaz Mahmoudvand, Simin Farokhi, Alireza Shadab, Mojtaba Kashfi, Hamed Afkhami   +5 more
doaj   +1 more source

Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila

eLife, 2018
Recent lineage tracing analyses have significantly improved our understanding of immune system development and highlighted the importance of the different hematopoietic waves.
Wael Bazzi, Pierre B Cattenoz, Claude Delaporte, Vasanthi Dasari, Rosy Sakr, Yoshihiro Yuasa, Angela Giangrande   +6 more
doaj   +1 more source

Insanity as a Defense to the Civil Fraud Penalty [PDF]

, 1963
Most neurological diseases are associated with chronic inflammation initiated by the activation of microglia, which produce cytotoxic and inflammatory factors.
Dabrowski, Michal, Ellert-Miklaszewska, Aleksandra, Hu, Feng, Kaminska, Bozena, Kaza, Beata, Kettenmann, Helmut, Kloss, Michal, Komorowski, Jan, Mieczkowski, Jakub, Piotrowski, Arkadiusz, Przanowski, Piotr, Ronowicz, Anna   +11 more
core   +2 more sources