Results 51 to 60 of about 207,642 (299)

Essential cell-autonomous role for interferon (IFN) regulatory factor 1 in IFN-γ-mediated inhibition of norovirus replication in macrophages [PDF]

, 2012
Noroviruses (NVs) cause the majority of cases of epidemic nonbacterial gastroenteritis worldwide and contribute to endemic enteric disease. However, the molecular mechanisms responsible for immune control of their replication are not completely ...
Duan, Erning, Goel, Gautam, Hwang, Seungmin, Maloney, Nicole S, Thackray, Larissa B, Vachharajani, Punit, Virgin, Herbert W, Xavier, Ramnik   +7 more
core   +2 more sources

Double-edged sword of JAK/STAT signaling pathway in viral infections: novel insights into virotherapy

Cell Communication and Signaling, 2023
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) is an intricate signaling cascade composed of various cytokines, interferons (IFN, growth factors, and other molecules.
Mohamad Mahjoor, Golnaz Mahmoudvand, Simin Farokhi, Alireza Shadab, Mojtaba Kashfi, Hamed Afkhami   +5 more
doaj   +1 more source

Epigenetic signals that direct cell type–specific interferon beta response in mouse cells

Life Science Alliance, 2023
Preexisting cell type–specific chromatin features represent an additional regulatory layer for interferon beta response and direct binding of STAT transcription factors and gene induction. The antiviral response induced by type I interferon (IFN) via the
Markus Muckenhuber, Isabelle Seufert, Katharina Müller-Ott, Jan-Philipp Mallm, Lara C Klett, Caroline Knotz, Jana Hechler, Nick Kepper, Fabian Erdel, Karsten Rippe   +9 more
doaj   +1 more source

Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication

Frontiers in Oncology, 2019
Signal Transducer and Activator of Transcription (STAT) pathway is connected upstream with Janus kinases (JAK) family protein and capable of integrating inputs from different signaling pathways.
Chin-Yap Loh, Aditya Arya, Ahmed Fadhil Naema, Won Fen Wong, Gautam Sethi, Chung Yeng Looi   +5 more
doaj   +1 more source

Understanding signaling cascades in melanoma [PDF]

, 2008
Understanding regulatory pathways involved in melanoma development and progression has advanced significantly in recent years. It is now appreciated that melanoma is the result of complex changes in multiple signaling pathways that affect growth control,
Akslen L. A., Berger A. J., Berking C., Bhoumik A., Bhoumik A., Chen X., Claffey K. P., Collisson E. A., Coppock D. L., Dahia P. L. M., Dhawan P., Dorsky R. I., Ehebauer M., Eisenmann K. M., Genersch E., Goding C. R., Goodall J., Gorden A., Guldberg P., Gurzov E. N., Herbst R. A., Hingorani S. R., Hughes M. J., Huguier S., Iozzo R. V., Jonsson M., Jorgensen K., Karin M., Kennedy N. J., Kumar R., Lacal P. M., Li N., Maeno K., Meyskens F. L., Miller J. R., Miyazono K., Niu G., Okuyama R., Omholt K., Park B. K., Piek E., Qin J.-Z., Rangaswami H., Rimm D. L., Rofstad E. K., Satyamoorthy K., Soldatencov V. A., Stewart F. A., Tago K.-i., Thomson J. A., Tokita T., Tsai E. Y., Tsao H., van Elsas A., Wu M., Yang J., Yang J., Yang Y. M., Zhou X. P.   +58 more
core   +1 more source

Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila

eLife, 2018
Recent lineage tracing analyses have significantly improved our understanding of immune system development and highlighted the importance of the different hematopoietic waves.
Wael Bazzi, Pierre B Cattenoz, Claude Delaporte, Vasanthi Dasari, Rosy Sakr, Yoshihiro Yuasa, Angela Giangrande   +6 more
doaj   +1 more source

Genomics analysis on the responses of E. coli cells to varying environmental conditions [PDF]

, 2016
The natural living environments of E. coli cells are diverse, varying from mammalian gastrointestinal tracts and soil. Each environment might require distinct metabolic pathways and transporter systems, and long-term evolution has established elaborate ...
Yan, Xiwei
core   +1 more source

Constitutive activation of STAT transcription factors in acute myelogenous leukemia

European Journal of Haematology, 2001
Abstract: Hematopoietic growth factors (HGF) are essential for proliferation and differentiation of hematopoietic precursors and activate a distinct set of JAK‐STAT (Janus kinases‐signal transducers and activators of transcription) proteins. Previous results from our group have shown a strong expression of JAK‐STAT proteins in primary acute myelogenous
Spiekermann, Karsten, Biethahn, S., Wilde, S., Hiddemann, Wolfgang, Alves, Frauke   +4 more
openaire   +3 more sources

Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila. [PDF]

PLoS Biology, 2007
The activation of several transcription factors is required for the elimination of infectious pathogens via the innate immune response. The transcription factors NF-kappaB, AP-1, and STAT play major roles in the synthesis of immune effector molecules ...
Lark Kyun Kim, Un Yung Choi, Hwan Sung Cho, Jung Seon Lee, Wook-bin Lee, Jihyun Kim, Kyoungsuk Jeong, Jaewon Shim, Jeongsil Kim-Ha, Young-Joon Kim   +9 more
doaj   +1 more source

Loss of signal transducer and activator of transcription 1 is associated with prostate cancer recurrence [PDF]

, 2015
STAT1 loss has previously been implicated in cell line studies to modify prostate cancer cell growth and survival, however the clinical significance of this has not previously been established.
Edwards, Joanne, Hatziieremia, Sophia, McCall, Pamela, Mohammed, Zahra, Roseweir, Antonia K., Underwood, Mark A., Willder, Jennifer M.   +6 more
core   +1 more source