Results 31 to 40 of about 8,110,955 (261)
Frontiers in Oncology, 2019 Signal Transducer and Activator of Transcription (STAT) pathway is connected upstream with Janus kinases (JAK) family protein and capable of integrating inputs from different signaling pathways.
Chin-Yap Loh +5 more
doaj +1 more source
Cell Communication and Signaling, 2023 The Janus kinase/signal transducer and activator of transcription (JAK/STAT) is an intricate signaling cascade composed of various cytokines, interferons (IFN, growth factors, and other molecules.
Mohamad Mahjoor +5 more
doaj +1 more source
Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila
eLife, 2018 Recent lineage tracing analyses have significantly improved our understanding of immune system development and highlighted the importance of the different hematopoietic waves.
Wael Bazzi +6 more
doaj +1 more source
MIRTFnet: analysis of miRNA regulated transcription factors. [PDF]
, 2011 Several expression datasets of miRNA transfection experiments are available to analyze the regulatory mechanisms downstream of miRNA effects. The miRNA induced regulatory effects can be propagated via transcription factors (TFs).
Küffner, Robert +11 more
core +1 more source
Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila. [PDF]
PLoS Biology, 2007 The activation of several transcription factors is required for the elimination of infectious pathogens via the innate immune response. The transcription factors NF-kappaB, AP-1, and STAT play major roles in the synthesis of immune effector molecules ...
Lark Kyun Kim +9 more
doaj +1 more source
Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
Signal Transduction and Targeted Therapy, 2023 The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved mechanism of transmembrane signal transduction that enables cells to communicate with the exterior environment.
Chen Xue +8 more
doaj +1 more source
STAT is an essential activator of the zygotic genome in the early Drosophila embryo.
PLoS Genetics, 2011 In many organisms, transcription of the zygotic genome begins during the maternal-to-zygotic transition (MZT), which is characterized by a dramatic increase in global transcriptional activities and coincides with embryonic stem cell differentiation.
Amy Tsurumi +5 more
doaj +1 more source
Investigating the role of the JAK/STAT and MAPK pathways in ischaemia/reperfusion injury and inflammation [PDF]
, 2009 The signal transducer and activator of transcription (STAT) proteins are a family of transcription factors which transduce extracellular signals from cytokines, growth factors and G-proteins to the nucleus.
Barry, S.P.
core
Nucleosome-mediated cooperativity between transcription factors [PDF]
, 2009 Cooperative binding of transcription factors (TFs) to cis-regulatory regions (CRRs) is essential for precision of gene expression in development and other processes.
Leonid A. Mirny, Mirny, Leonid A
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source