Transcriptome analysis reveals modulation of the STAT family in PEDV-infected IPEC-J2 cells
BMC Genomics, 2020 Background Porcine epidemic diarrhea virus (PEDV) is a causative agent of serious viral enteric disease in suckling pigs. Such diseases cause considerable economic losses in the global swine industry.
Zhengzheng Hu +6 more
doaj +1 more source
JAK/STAT signaling in diabetic kidney disease
Frontiers in Cell and Developmental Biology, 2023 Diabetic kidney disease (DKD) is the most important microvascular complication of diabetes and the leading cause of end-stage renal disease (ESRD) worldwide.
Yingjun Liu +5 more
doaj +1 more source
STAT Proteins in Innate Immunity during Sepsis: Lessons from Gene Knockout Mice [PDF]
, 2007 The innate immune system provides immediate defense against infection and serves as the first line of host defense during infection. In innate immunity, leukocytes such as neutrophils and macrophages recognize and respond to pathogens in a non-specific ...
Matsukawa, Akihiro
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A key role for leukemia inhibitory factor in C26 cancer cachexia [PDF]
, 2015 Cachexia is an exacerbating event in many types of cancer that is strongly associated with a poor prognosis. We have identified cytokine, signaling, and transcription factors that are required for cachexia in the mouse C26 colon carcinoma model of cancer.
Jackman, Robert W. +2 more
core +1 more source
BMC Infectious Diseases, 2019 Background Leprosy is an ideal human disease to study T cell regulation as patients show correlation between cytokine skewed Th1-Th2 responses and clinical forms of the disease. The Role of transcription factors on the modulation of Th1 and Th2 responses
Rajni Upadhyay +6 more
doaj +1 more source
A multiple-instance scoring method to predict tissue-specific cis-regulatory motifs and regions [PDF]
, 2009 Transcription is the central process of gene regulation. In higher eukaryotes, the transcription of a gene is usually regulated by multiple cis-regulatory regions (CRRs).
Jin Gu
core +2 more sources
Interactions between STAT and Non-STAT Proteins in the Interferon-Stimulated Gene Factor 3 Transcription Complex [PDF]
Molecular and Cellular Biology, 1996 The first STAT-containing transcription factor to be studied, the alpha-interferon-induced ISGF3, is composed of a Stat1:2 heterodimer and a weak DNA-binding protein, p48, that is a member of a growing family of proteins similar to the so-called interferon regulatory factor (IRF-1). The p48 and Stat1:2 heterodimer do not associate stably in the absence
C M, Horvath +3 more
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Emerging Topical and Systemic JAK Inhibitors in Dermatology [PDF]
, 2019 Accumulating data on cellular and molecular pathways help to develop novel therapeutic strategies in skin inflammation and autoimmunity. Examples are psoriasis and atopic dermatitis, two clinically and immunologically well-defined disorders.
Ghoreschi, Kamran +2 more
core +1 more source
A multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis. [PDF]
PLoS Computational Biology, 2014 Systemic iron homeostasis involves a negative feedback circuit in which the expression level of the peptide hormone hepcidin depends on and controls the iron blood levels. Hepcidin expression is regulated by the BMP6/SMAD and IL6/STAT signaling cascades.
Guillem Casanovas +4 more
doaj +1 more source
Essential cell-autonomous role for interferon (IFN) regulatory factor 1 in IFN-γ-mediated inhibition of norovirus replication in macrophages [PDF]
, 2012 Noroviruses (NVs) cause the majority of cases of epidemic nonbacterial gastroenteritis worldwide and contribute to endemic enteric disease. However, the molecular mechanisms responsible for immune control of their replication are not completely ...
Duan, Erning +7 more
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