Results 21 to 30 of about 8,110,955 (261)

JAK/STAT signaling in diabetic kidney disease

Frontiers in Cell and Developmental Biology, 2023
Diabetic kidney disease (DKD) is the most important microvascular complication of diabetes and the leading cause of end-stage renal disease (ESRD) worldwide.
Yingjun Liu, Wenkuan Wang, Jintao Zhang, Shuo Gao, Tingting Xu, Yonghui Yin   +5 more
doaj   +1 more source

Variable structure motifs for transcription factor binding sites [PDF]

, 2010
Background: Classically, models of DNA-transcription factor binding sites (TFBSs) have been based on relatively few known instances and have treated them as sites of fixed length using position weight matrices (PWMs).
Evans, Kenneth J., Dyer, N., Nigel Dyer, Ott Sascha, Reid, J.E., Lorenz Wernisch, Sascha Ott, Ott, S., Wernisch Lorenz, John E Reid, Evans Kenneth J, Wernisch, Lorenz, Reid, J. E. (John E.), Kenneth J Evans, Dyer, Nigel, Dyer Nigel, Ott, Sascha, Reid John E   +17 more
core   +6 more sources

Increased STAT1 signaling in endocrine-resistant breast cancer [PDF]

, 2014
Funding: China Scholarship Council, University of Edinburgh, Scottish Funding Council and Breakthrough Breast Cancer.Proteomic profiling of the estrogen/tamoxifen-sensitive MCF-7 cell line and its partially sensitive (MCF-7/LCC1) and fully resistant (MCF-
Thomas Jeremy S., Faratian Dana, Huang Rui, Sims Andrew H., Dana Faratian (171110), Simon P. Langdon, Danielle Wilson (550968), David J. Harrison (171106), Jeremy S. Thomas, Dana Faratian, Rui Huang, Wilson Danielle, Harrison David J., David J. Harrison, Danielle Wilson, Simon P Langdon, Thomas, Jeremy S, Sims, Andrew H, Andrew H. Sims (108040), Harrison, David J, Rui Huang (141490), Huang, Rui, Simon P. Langdon (207293), Wilson, Danielle, David J Harrison, Thomas, Jeremy, Langdon Simon P., Faratian, Dana, Andrew H. Sims, Andrew H Sims, Jeremy S Thomas, Jeremy S. Thomas (550969), Langdon, Simon P   +32 more
core   +2 more sources

Potential Transcription Factors for Biotic Stress Tolerance in Sugarcanee

, 2022
Sugarcane is an economically important crop plant under the family of Poaceae. It provides approximately 80% of sugar required for human consumption in the world.
Islam, T, Chakraborty, M, Munshi, SK, Shiddiky, MJA   +3 more
core   +1 more source

Plant Transcription Factors @ uni-potsdam.de [PDF]

, 2007
We present the Plant Transcription Factor Database (PlnTFDB), and the putative complete set of TFs in the algae _Chlamydomonas reinhardtii_, _Ostreococcus tauri_ and the vascular plants _Oryza sativa_ and _Arabidopsis ...
Slobodan Ruzicic, Ingo Dreyer, Diego Mauricio Riaño-Pachón, Bernd Mueller-Roeber   +3 more
core   +1 more source

A multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis. [PDF]

PLoS Computational Biology, 2014
Systemic iron homeostasis involves a negative feedback circuit in which the expression level of the peptide hormone hepcidin depends on and controls the iron blood levels. Hepcidin expression is regulated by the BMP6/SMAD and IL6/STAT signaling cascades.
Guillem Casanovas, Anashua Banerji, Flavia d'Alessio, Martina U Muckenthaler, Stefan Legewie   +4 more
doaj   +1 more source

A local regulatory network around three NAC transcription factors in stress responses and senescence in Arabidopsis leaves [PDF]

, 2013
A model is presented describing the gene regulatory network surrounding three similar NAC transcription factors that have roles in Arabidopsis leaf senescence and stress responses. ANAC019, ANAC055 and ANAC072 belong to the same clade of NAC domain genes
Cooke, Emma J., Jonathan D. Moore, Laura Bowden, Katherine J. Denby, Hickman, Richard J., Beynon, Jim, Richard Hickman, Findlay Bewicke‐Copley, David L. Wild, Vicky Buchanan‐Wollaston, Jim Beynon, Jackson, Alison C., Denby, Katherine J., Mead, A. (Andrew), Penfold, Christopher A., Bowden, Laura, Andrew Mead, Wild, David L., Christopher A. Penfold, Moore, Jonathan D., Emily Breeze, Breeze, Emily, Alison Jackson, Sascha Ott, Buchanan-Wollaston, Vicky, Peijun Zhang, Emma Cooke, Hill, C., Zhang, Peijun, Bewicke-Copley, Findlay, Claire Hill, Ott, Sascha   +31 more
core   +1 more source

Evolutionary, comparative, and functional analyses of STATs and regulation of the JAK-STAT pathway in lumpfish upon bacterial and poly(I:C) exposure

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundThe Janus kinase/signal transducers and activators of transcription (JAK-STAT) system regulates several biological processes by affecting transcription of genes as a response to cytokines and growth factors.
Shreesha S. Rao, Patrick A. Nelson, Harald S. Lunde, Gyri T. Haugland   +3 more
doaj   +1 more source

Epigenetic signals that direct cell type–specific interferon beta response in mouse cells

Life Science Alliance, 2023
Preexisting cell type–specific chromatin features represent an additional regulatory layer for interferon beta response and direct binding of STAT transcription factors and gene induction. The antiviral response induced by type I interferon (IFN) via the
Markus Muckenhuber, Isabelle Seufert, Katharina Müller-Ott, Jan-Philipp Mallm, Lara C Klett, Caroline Knotz, Jana Hechler, Nick Kepper, Fabian Erdel, Karsten Rippe   +9 more
doaj   +1 more source

Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition. [PDF]

, 2014
The Ets family of eukaryotic transcription factors is based around the conserved Ets DNA-binding domain. Although their DNA-binding selectivity is biochemically and structurally well characterized, structures of homodimeric and ternary complexes point to
Gileadi, Opher, Newman, JA, Cooper, CD, Joseph A Newman, Gileadi, O, Cooper, Christopher D.O., Christopher D O Cooper, Newman, Joseph A., Opher Gileadi   +8 more
core   +1 more source