Results 11 to 20 of about 207,076 (296)
Targeting Oncogenic Transcription Factors: Therapeutic Implications of Endogenous STAT Inhibitors [PDF]
Trends in Cancer, 2017 Misregulation of transcription factors, including signal transducer and activator of transcription (STAT) proteins, leads to inappropriate gene expression patterns that can promote tumor initiation and progression. Under physiologic conditions, STAT signaling is stimulus dependent and tightly regulated by endogenous inhibitors, namely, suppressor of ...
Lisa N, Heppler, David A, Frank
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Activation of STAT transcription factors in oncogenic tyrosine kinase signaling
Journal of Biomedical Science, 1998 Signal transducers and activators of transcription (STATs) are cytoplasmic transcription factors that translocate to the nucleus and regulate gene expression in response to cytokine and growth factor stimulation. Emerging evidence indicates that STAT signaling is also frequently activated by oncogenes and in tumor cells. Constitutive activation of STAT
R, Garcia, R, Jove
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Interactions of the Nipah Virus P, V, and W Proteins across the STAT Family of Transcription Factors
mSphere, 2020 The Nipah virus (NiV) phosphoprotein (P) gene encodes four proteins. Three of these—P, V, and W—possess a common N-terminal domain but distinct C termini. These proteins interact with immune modulators. Previous studies demonstrated that P, V, and W bind
Timothy R. Keiffer +3 more
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Research progress on the role of STAT in the pathogenesis of dermatosis [PDF]
Jichu yixue yu linchuang, 2021 Signal transducer and activator of transcription (STAT) proteins with transcriptional activity, which are involved in the pathogenesis and formation of skin lesions of atopic dermatitis, psoriasis, skin tumors and other dermatosis, and are related to the
ZHOU Qiong-yan, LIN Wei, XU Su-ling, ZHAO Ke-yu
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Nuclear export determines the cytokine sensitivity of STAT transcription factors [PDF]
GBM Annual Fall meeting Berlin/Potsdam 2005, 2005 Cytokine-dependent gene activation critically depends upon the tyrosine phosphorylation (activation) of STAT transcription factors at membrane-bound cytokine receptors. The extent of STAT activation and hence the specificity of signaling is primarily determined by structural complementarity between the SH2 domain of the STATs and the tyrosine ...
Inga, Lödige +5 more
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STAT proteins in cancerogenesis and therapy of malignancies [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2009 Signal transducers and activators of transcription (STAT) proteins are a 7-member family of cytoplasmic transcription fators that participate in signal transduction by cytokines, hormones, and growth factors.
Konjević Gordana
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Multi-Source Pathways of T Follicular Helper Cell Differentiation
Frontiers in Immunology, 2021 T follicular helper (Tfh) cells participate in humoral immune by promoting inflammation and aiding B cells survival, proliferation, maturation, and generation autoantibodies.
Xiaoxue Ma +5 more
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Factors increasing the risk of mortality and morbidity due to coronavirus infection in patients with metabolic syndrome [PDF]
Precision and Future Medicine, 2020 Patients living with comorbid metabolic syndrome (MS) and metabolic disorders such as obesity and type 2 diabetes mellitus carry increased levels of circulating cytokines and systemic low-grade inflammation.
Altansuvd Enkhtur +2 more
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Suppression of Autoimmune Arthritis by Small Molecule Inhibitors of the JAK/STAT Pathway
Pharmaceuticals, 2010 A skewed ratio of pro-inflammatory to anti-inflammatory cytokines, elevated growth factor synthesis and T- and B-lymphocyte activation are 3 hallmarks of rheumatoid arthritis (RA) pathology.
Charles J. Malemud
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mBio, 2021 Acute antiviral functions of all nucleated cells rely on type I interferon (IFN-I) pathways triggered upon viral infection. Host responses encompass the sensing of incoming viruses, the activation of specific transcription factors that induce the ...
Mickaël Bouvet +10 more
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