Results 11 to 20 of about 8,110,955 (261)

Transcription factors STAT-4, STAT-6 and CREB regulate Th1/Th2 response in leprosy patients: effect of M. leprae antigens

BMC Infectious Diseases, 2019
Background Leprosy is an ideal human disease to study T cell regulation as patients show correlation between cytokine skewed Th1-Th2 responses and clinical forms of the disease. The Role of transcription factors on the modulation of Th1 and Th2 responses
Rajni Upadhyay, Bhavyata Dua, Bhawna Sharma, Mohan Natrajan, Ajai Kumar Jain, Balaji Kithiganahalli Narayanaswamy, Beenu Joshi   +6 more
doaj   +2 more sources

Multiple Viral microRNAs Regulate Interferon Release and Signaling Early during Infection with Epstein-Barr Virus

mBio, 2021
Acute antiviral functions of all nucleated cells rely on type I interferon (IFN-I) pathways triggered upon viral infection. Host responses encompass the sensing of incoming viruses, the activation of specific transcription factors that induce the ...
Mickaël Bouvet, Stefanie Voigt, Takanobu Tagawa, Manuel Albanese, Yen-Fu Adam Chen, Yan Chen, Devin N. Fachko, Dagmar Pich, Christine Göbel, Rebecca L. Skalsky, Wolfgang Hammerschmidt   +10 more
doaj   +1 more source

The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells [PDF]

, 2012
This article is available open access under a Creative Commons license (http://creativecommons.org/licenses/by-nc-nd/3.0/). Copyright @ 2012 Elsevier Inc.Lymphocytes provide optimal responses against pathogens with minimal inflammatory pathology. However,
Miao, T, Bhullar, P, Ghaffari, Emma, Liu, Mengya, Liu, M, Wang, Ping, Miao, Tizong, Li, Suling, Wang, P, Sebastian, M, Ghaffari, E, Sebastian, Meera, Symonds, Alistair L.J., Li, S, Symonds, ALJ, Bhullar, Punamdip   +15 more
core   +1 more source

Distinct transcriptomic features are associated with transitional and mature B-cell populations in the mouse spleen

Frontiers in Immunology, 2015
Splenic transitional B-cells (T1 and T2) are selected to avoid self-reactivity and to safeguard against autoimmunity, then differentiate into mature follicular (FO-I and FO-II) and marginal zone (MZ) subsets.
Eden eKleiman, Daria eSalyakina, Magali eDe Heusch, Magali eDe Heusch, Kristen L Hoek, Joan M Llanes, Iris eCastro, Jacqueline A Wright, Emily S Clark, Derek Michael Dykxhoorn, Akiko eTakeda, Enrico eCapobianco, Jean-Christophe eRenauld, Jean-Christophe eRenauld, Wasif N Khan   +14 more
doaj   +1 more source

Identification of cis-regulatory sequences reveals potential participation of lola and Deaf1 transcription factors in Anopheles gambiae innate immune response. [PDF]

PLoS ONE, 2017
The innate immune response of Anopheles gambiae involves the transcriptional upregulation of effector genes. Therefore, the cis-regulatory sequences and their cognate binding factors play essential roles in the mosquito's immune response.
Bernardo Pérez-Zamorano, Sandra Rosas-Madrigal, Oscar Arturo Migueles Lozano, Manuel Castillo Méndez, Verónica Valverde-Garduño   +4 more
doaj   +1 more source

JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens

Frontiers in Bioengineering and Biotechnology, 2023
Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were originally thought to be intracellular signaling pathways that mediate cytokine signals in mammals.
Qian Hu, Qian Hu, Qian Hu, Qian Hu, Qihui Bian, Dingchao Rong, Leiyun Wang, Leiyun Wang, Leiyun Wang, Jianan Song, Hsuan-Shun Huang, Jun Zeng, Jie Mei, Jie Mei, Jie Mei, Peng-Yuan Wang   +15 more
doaj   +1 more source

Multiple sequence-specific transcription factors modulate cytomegalovirus enhancer activity in vitro [PDF]

, 1988
The possibility of DNA-binding proteins interacting in vitro with the polymerase II transcriptional machinery was explored by using a competition assay with individual target sequences for enhancer-binding factors.
Lubon, H, Lubon, Henryk, Hennighausen, L, Hennighausen, Lothar, Ghazal, Peter, Ghazal, P   +5 more
core   +1 more source

Comprehensive meta-analysis of Signal Transducers and Activators of Transcription (STAT) genomic binding patterns discerns cell-specific cis-regulatory modules

BMC Genomics, 2013
Background Cytokine-activated transcription factors from the STAT (Signal Transducers and Activators of Transcription) family control common and context-specific genetic programs.
Kang Keunsoo, Robinson Gertraud W, Hennighausen Lothar   +2 more
doaj   +1 more source

Signal transducer and activator of transcription-1 localizes to the mitochondria and modulates mitophagy [PDF]

, 2013
The signal transducer and activator of transcription (STAT) proteins are latent transcription factors that have been shown to be involved in cell proliferation, development, apoptosis, and autophagy. STAT proteins undergo activation by phosphorylation at
Stephanou, A., McCormick, J., Latchman, David S., Knight, R,A,, Bourke, L.T.   +4 more
core   +1 more source

Transcriptome analysis reveals modulation of the STAT family in PEDV-infected IPEC-J2 cells

BMC Genomics, 2020
Background Porcine epidemic diarrhea virus (PEDV) is a causative agent of serious viral enteric disease in suckling pigs. Such diseases cause considerable economic losses in the global swine industry.
Zhengzheng Hu, Yuchen Li, Heng Du, Junxiao Ren, Xianrui Zheng, Kejian Wei, Jianfeng Liu   +6 more
doaj   +1 more source