Results 51 to 60 of about 110,595 (300)
STAT3 gain-of-function mutation in a patient with pulmonary Mycobacterium abscessus infection
Respiratory Medicine Case Reports, 2020 Background: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor involved in cellular proliferation, apoptosis, and differentiation.
Miguel S. Gonzalez-Mancera +2 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
, 2007 The GH-activated signal transducer and activator of transcription 5b (STAT5b) is an essential regulator of somatic growth. The transcriptional response to STAT5b in liver is poorly understood.
Fernandez-Perez, Leandro +10 more
core +1 more source
Taiwanese Journal of Obstetrics & Gynecology, 2012 Objective: Signal transducer and activator of transcription (STAT)1 is a key tumor suppressor, which is always methylated in a variety of human cancers.
Ming-Cheng Chang +6 more
doaj +1 more source
Signal Transducer and Activator of Transcription 4 in Liver Diseases [PDF]
International Journal of Biological Sciences, 2015 STAT4 is a member of the signal transducer and activator of transcription (STAT) family of molecules that localizes to the cytoplasm. STAT4 regulates various genes expression as a transcription factor after it is phosphorylated, dimerizes and translocates to the nucleus.
Wang, Yan, Qu, Aijuan, Wang, Hua
openaire +2 more sources
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection [PDF]
, 2012 Includes abstract.Includes bibliographical references.Moderate and chronic consumption of red wine confers cardioprotection. Melatonin, present in wine, may contribute to this cardioprotective effect. Melatonin confers cardioprotection via the activation
Albertyn, Zulfah
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
The Role of Signal Transducer and Activator of Transcription 3 (STAT3) in Tumor Immunity [PDF]
, 2012 BACKGROUND: Inflammation is a key component of the tumor microenvironment. Cancer-associated inflammation is marked by the presence of specific inflammatory cells and inflammatory mediators.
M Nurhalim Shahib +3 more
core +1 more source
Skeletal Muscle, 2021 Background The signal transducer and activator of transcription 6 (STAT6) transcription factor plays a vitally important role in immune cells, where it is activated mainly by interleukin-4 (IL-4).
Mitsutoshi Kurosaka +4 more
doaj +1 more source