Epithelial cell–derived secreted and transmembrane 1a signals to activated neutrophils during pneumococcal pneumonia [PDF]
, 2016 Airway epithelial cell responses are critical to the outcome of lung infection. In this study, we aimed to identify unique contributions of epithelial cells during lung infection.
Belkina, Anna C. +12 more
core +1 more source
S-Glutathionylation Impairs Signal Transducer and Activator of Transcription 3 Activation and Signaling [PDF]
Endocrinology, 2008 S-glutathionylation is a physiological, reversible protein modification of cysteine residues with glutathione in response to mild oxidative stress. Because the key cell growth regulator signal transducer and activator of transcription (STAT) 3 is particularly susceptible to redox regulation, we hypothesized that oxidative modification of cysteine ...
Yi, Xie +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Ligand induced cleavage and nuclear localization of the rice XA21 immune receptor [PDF]
, 2012 The rice XA21 receptor confers immunity to the Gram-negative bacterial pathogen, _Xanthomonas oryzae_ pv. _oryzae_ (_Xoo_) upon recognition of the conserved microbial signature AxY^S^22.
Chang-Jin Park, Pamela C. Ronald
core +1 more source
Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain [PDF]
, 2010 The consumption of flavonoid-rich foods and beverages has been suggested to limit the neurodegeneration associated with a variety of neurological disorders and to prevent or reverse normal or abnormal deteriorations in cognitive performance.
Spencer, Jeremy Paul
core +1 more source
Aberrant activation of signal transducer and activator of transcription-3 (STAT3) signaling in endometriosis [PDF]
Human Reproduction, 2015 Are STAT3 signaling molecules differentially expressed in endometriosis?
Byung Gak, Kim +9 more
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
EPHA2, a promising therapeutic target for hepatocellular carcinoma
Molecular & Cellular Oncology, 2021 Identifying critical drivers of oncogenesis and tumor progression is essential for developing effective hepatocellular carcinoma (HCC) therapeutics. Our recent findings has demonstrated that targeting Ephrin Receptor A2 (EPHA2) suppresses HCC initiation ...
Hao Wang, Wei Qiu
doaj +1 more source
The crosstalk between STAT3 and microRNA in cardiac diseases and protection
Frontiers in Cardiovascular Medicine, 2022 Signal transducer and activator of transcription 3 (STAT3), an important transcription factor and signaling molecule, play an important role in cardiac disease and protection. As a transcription factor, STAT3 upregulates anti-oxidative and anti-apoptotic
Lan Wu +4 more
doaj +1 more source
Differential Tissue Response to Growth Hormone in Mice [PDF]
, 2018 Growth hormone (GH) has been shown to act directly on multiple tissues throughout the body. Historically, it was believed that GH acted directly in the liver and only indirectly in other tissues via insulin‐like growth hormone 1 (IGF‐1).
Banerjee, Ronadip R. +4 more
core +2 more sources