The Roles of Signal Transducer and Activator of Transcription 3 in Tumor Metastasis [PDF]
Chinese Journal of Lung Cancer, 2010 Lei GONG, Zhihao WU, Qinghua ZHOU
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Research progress on the role of STAT in the pathogenesis of dermatosis [PDF]
Jichu yixue yu linchuang, 2021 Signal transducer and activator of transcription (STAT) proteins with transcriptional activity, which are involved in the pathogenesis and formation of skin lesions of atopic dermatitis, psoriasis, skin tumors and other dermatosis, and are related to the
ZHOU Qiong-yan, LIN Wei, XU Su-ling, ZHAO Ke-yu
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Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications. [PDF]
, 2014 Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival.
Bonavida, Benjamin, Shvartsur, Anna
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Janus kinases: dermatological perspective, a review
Journal of the Egyptian Women’s Dermatologic Society, 2020 Janus kinases (JAKs) are a group of nonreceptor intracellular tyrosine kinases that could modify cytokine-mediated signals through the JAK-signal transducer and activator of transcription pathway.
Hanan R Nada +3 more
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Kynurenine–PARP-1 Link Mediated by MicroRNA 210 May Be Dysregulated in Pulmonary Hypertension
Anatolian Journal of Cardiology, 2022 Background: Dysregulation of microRNAs is associated with pulmonary hypertension. The present study aimed to determine the alterations in microRNA and microRNA expressions and their role in signaling pathways and investigate the relationship with serum ...
Alperen Emre Akgun +4 more
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Signal transducer and activator of transcription-1 localizes to the mitochondria and modulates mitophagy [PDF]
, 2013 The signal transducer and activator of transcription (STAT) proteins are latent transcription factors that have been shown to be involved in cell proliferation, development, apoptosis, and autophagy. STAT proteins undergo activation by phosphorylation at
Ambrosio G +9 more
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STATs: Signal Transducers and Activators of Transcription [PDF]
Cell, 1996 One might anticipate exciting new information regarding the STATs in several areas. First, several intriguing questions remain regarding STAT structure. Given the nature of the proposed intermolecular SH2–phosphotyrosine interactions and the requirement for the interaction of the DNA-binding domains (try making models), the molecular structures of the ...
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Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer. [PDF]
, 2016 BackgroundHyperactivation of STAT3 via constitutive phosphorylation of tyrosine 705 (Y705) is common in most human cancers, including head and neck squamous carcinoma (HNSCC).
Gooding, William E +5 more
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Targeting STAT3 in Cancer with Nucleotide Therapeutics. [PDF]
, 2019 Signal transducer and activator of transcription 3 (STAT3) plays a critical role in promoting the proliferation and survival of tumor cells. As a ubiquitously-expressed transcription factor, STAT3 has commonly been considered an "undruggable" target for ...
Grandis, Jennifer R +3 more
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Role of JAK-STAT signaling pathway in pathogenesis and treatment of primary Sjögren's syndrome
Chinese Medical Journal, 2023 . Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with high prevalence and possible poor prognosis. Though the pathogenesis of pSS has not been fully elucidated, B cell hyperactivity is considered as one of the fundamental abnormalities
Mucong Li +7 more
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