Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses
Frontiers in Immunology, 2018 Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated downstream of many key cytokine receptors expressed by lymphocytes.
Elissa K. Deenick +9 more
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Signal Transducer and Activator of Transcription 3 in Liver Diseases: A Novel Therapeutic Target
International Journal of Biological Sciences, 2011 Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated by many cytokines and growth factors and plays a key role in cell survival, proliferation, and differentiation.
Hua Wang, Fouad Lafdil, Xiaoni Kong, Bin Gao
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Kynurenine–PARP-1 Link Mediated by MicroRNA 210 May Be Dysregulated in Pulmonary Hypertension
Anatolian Journal of Cardiology, 2022 Background: Dysregulation of microRNAs is associated with pulmonary hypertension. The present study aimed to determine the alterations in microRNA and microRNA expressions and their role in signaling pathways and investigate the relationship with serum ...
Alperen Emre Akgun +4 more
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STATs: Signal Transducers and Activators of Transcription [PDF]
Cell, 1996 One might anticipate exciting new information regarding the STATs in several areas. First, several intriguing questions remain regarding STAT structure. Given the nature of the proposed intermolecular SH2–phosphotyrosine interactions and the requirement for the interaction of the DNA-binding domains (try making models), the molecular structures of the ...
openaire +2 more sources
The inhibition of Stat5 by a peptide aptamer ligand specific for the DNA binding domain prevents target gene transactivation and the growth of breast and prostate tumor cells [PDF]
, 2013 The signal transducer and activator of transcription Stat5 is transiently activated by growth factor and cytokine signals in normal cells, but its persistent activation has been observed in a wide range of human tumors.
Moriggl, Richard +15 more
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The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells [PDF]
, 2012 This article is available open access under a Creative Commons license (http://creativecommons.org/licenses/by-nc-nd/3.0/). Copyright @ 2012 Elsevier Inc.Lymphocytes provide optimal responses against pathogens with minimal inflammatory pathology. However,
Miao, T +15 more
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Clinicopathological significance of protein disulphide isomerase A3 and phosphorylated signal transducer and activator of transcription 3 in cervical carcinoma [PDF]
Contemporary OncologyAsmaa Abdullatif +7 more
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Role of JAK-STAT signaling pathway in pathogenesis and treatment of primary Sjögren's syndrome
Chinese Medical Journal, 2023 . Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with high prevalence and possible poor prognosis. Though the pathogenesis of pSS has not been fully elucidated, B cell hyperactivity is considered as one of the fundamental abnormalities
Mucong Li +7 more
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STAT5B (signal transducer and activator of transcription 5B) [PDF]
, 2012 Review on STAT5B (signal transducer and activator of transcription 5B), with data on DNA, on the protein encoded, and where the gene is ...
Del, Rosario AM +2 more
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Activity Analysis of the P2X Receptor Antagonist PPADS against Signal Transducer and Activator of Transcription Proteins. [PDF]
ChembiochemThe small molecule PPADS is a P2X receptor antagonist. Analysis of a library of known bioactive compounds in competitive fluorescence polarization-based assays indicates that PPADS and its isomer iso-PPADS also possess activity against members of the ...
Berg A, Gräber M, Berg T.
europepmc +2 more sources