-escin mitigates neuroinflammation and apoptosis caused by ischemic stroke through the inhibition of the interleukin-6/Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway [PDF]
Journal of International Medical ResearchObjective This study aimed to investigate the protective effects of β-escin against neuroinflammatory injury and its influence on the interleukin-6/Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway in a rat model of ...
Duan Yanqin +9 more
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Dihydrotanshinone I as a novel signal transducer and activator of transcription 3 inhibitor for glioblastoma treatment [PDF]
Journal of Translational MedicineBackground Among tumors affecting the central nervous system (CNS), glioblastoma multiforme (GBM) is the most aggressive and lethal form. Given the complex mechanisms of the CNS and the blood-brain barrier (BBB), effective therapies for GBM remain ...
Kai-wen Cheng +10 more
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Investigating the role of signal transducer and activator of transcription 3 in feline injection site sarcoma [PDF]
BMC Veterinary Research, 2022 Background Feline injection-site sarcomas (FISSs) are malignant mesenchymal tumors of different histotypes. The pathogenesis of FISS has been correlated with chronic inflammation, resulting in neoplastic transformation.
Cheng-Hsin Shih +3 more
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Ginsenoside Rd ameliorates muscle wasting by suppressing the signal transducer and activator of transcription 3 pathway [PDF]
Journal of Cachexia, Sarcopenia and Muscle, 2022 Background The effects of some drugs, aging, cancers, and other diseases can cause muscle wasting. Currently, there are no effective drugs for treating muscle wasting.
Yoseph Toni Wijaya +10 more
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NT157 Inhibits HCC Migration via Downregulating the STAT3/Jab1 Signaling Pathway
Technology in Cancer Research & Treatment, 2021 Purpose: The high fatality-to-case ratio of hepatocellular carcinoma is directly related to metastasis. The signal transducer and activator of transcription-3 is a key mediator of the cytokine and growth factor signaling pathways and drives the ...
SiZhe Yu +7 more
doaj +1 more source
Special Issue “Role of STAT3 in Oncogenesis”
Biomedicines, 2022 This Biomedicines Special Issue was designed to attract articles that focused on the pleiotropic role of the signal transducer and activator of transcription 3 (STAT3) transcription factor in different facets of tumorigenesis [...]
Kwang Seok Ahn
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The crosstalk between STAT3 and microRNA in cardiac diseases and protection
Frontiers in Cardiovascular Medicine, 2022 Signal transducer and activator of transcription 3 (STAT3), an important transcription factor and signaling molecule, play an important role in cardiac disease and protection. As a transcription factor, STAT3 upregulates anti-oxidative and anti-apoptotic
Lan Wu +4 more
doaj +1 more source
Clinicopathological significance of protein disulphide isomerase A3 and phosphorylated signal transducer and activator of transcription 3 in cervical carcinoma [PDF]
Contemporary OncologyAsmaa Abdullatif +7 more
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The relationship between microRNAs and the STAT3-related signaling pathway in cancer
Tumor Biology, 2017 MicroRNAs are non-coding RNAs that regulate gene expression by targeting messenger RNA molecules in 3′ untranslated region. Mounting evidence indicates that microRNAs regulate several factors to influence various biological activities that are related to
Lin Zhang +7 more
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STAT3 gain-of-function mutation in a patient with pulmonary Mycobacterium abscessus infection
Respiratory Medicine Case Reports, 2020 Background: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor involved in cellular proliferation, apoptosis, and differentiation.
Miguel S. Gonzalez-Mancera +2 more
doaj +1 more source