Results 41 to 50 of about 146,182 (290)

Signal transducer and activator of transcription-1 localizes to the mitochondria and modulates mitophagy [PDF]

, 2013
The signal transducer and activator of transcription (STAT) proteins are latent transcription factors that have been shown to be involved in cell proliferation, development, apoptosis, and autophagy. STAT proteins undergo activation by phosphorylation at
Ambrosio G, Coffer P, Decker RS, Decker RS, Harrison DA, Luo H, Menegazzi M, Sybers HD, Townsend PA, Turkson J   +9 more
core   +1 more source

Signal transducer and activator of transcription 3 (STAT3) promoter methylation and expression in pituitary adenoma

BMC Medical Genetics, 2017
Background Pituitary adenoma (PA) is a benign brain tumor that can cause neurological, endocrinological and ophthalmological aberrations. Till now there is a need to identify factors that can influence the tumor invasiveness and recurrence.
Indre Valiulyte, Giedrius Steponaitis, Daina Skiriute, Arimantas Tamasauskas, Paulina Vaitkiene   +4 more
doaj   +1 more source

Flurbiprofen ameliorates glucose deprivation-induced leptin resistance

Frontiers in Pharmacology, 2016
Leptin resistance is one of the mechanisms involved in the pathophysiology of obesity. The present study showed that glucose deprivation inhibited leptin-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) and signal ...
Toru Hosoi, Yuka Suyama, Takaaki Kayano, Koichiro Ozawa   +3 more
doaj   +1 more source

Signal transducer and activator of transcription-3 induces microRNA-155 expression in chronic lymphocytic leukemia. [PDF]

PLoS ONE, 2013
MicroRNA (miR) abnormalities play a key role in the pathogenesis of chronic lymphocytic leukemia (CLL). High levels of miR-155 have been detected in human neoplasms, and overexpression of miR-155 has been found to induce lymphoma in mice.
Ping Li, Srdana Grgurevic, Zhiming Liu, David Harris, Uri Rozovski, George A Calin, Michael J Keating, Zeev Estrov   +7 more
doaj   +1 more source

Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas.: Activating STAT3 mutations in hepatocellular adenoma [PDF]

, 2011
International audienceInflammatory hepatocellular adenomas (IHCAs) are benign liver tumors. 60% of these tumors have IL-6 signal transducer (IL6ST; gp130) mutations that activate interleukin 6 (IL-6) signaling.
Amessou, Mohamed, Balabaud, Charles, Bihl, Michel,, Bioulac-Sage, Paulette, Couchy, Gabrielle, Izard, Tina, Nault, Jean Charles, Nhieu, Jeanne Tran Van, Paradis, Valérie, Pilati, Camilla, Poussin, Karine, Zucman-Rossi, Jessica   +11 more
core   +5 more sources

ANGPTL3 affects the metastatic potential and the susceptibility of ovarian cancer cells to natural killer cell-mediated cytotoxicity

Heliyon, 2023
High metastatic potential and resistance to immunotherapy lead to poor survival in patients with ovarian cancer. Angiopoietin-like protein 3 is aberrantly expressed and exerts diverse roles in the progression of several cancers.
Yuxian Wu, Yaqun Zheng, Zhijun Jin
doaj   +1 more source

STAT3 (signal transducer and activator of transcription 3) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on STAT3 (signal transducer and activator of transcription 3), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +1 more source

Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer. [PDF]

, 2016
BackgroundHyperactivation of STAT3 via constitutive phosphorylation of tyrosine 705 (Y705) is common in most human cancers, including head and neck squamous carcinoma (HNSCC).
Gooding, William E, Grandis, Jennifer R, Johnson, Daniel E, Lui, Vivian WY, Pendleton, Kelsey, Peyser, Noah D   +5 more
core   +7 more sources

Signal Transducer and Activator of Transcription 3 for the Differentiation of Hepatocellular Carcinoma from Cirrhosis

Chinese Medical Journal, 2017
Background: Overexpression and constitutive activation of signal transducer and activator of transcription (STAT) 3 have been suggested in the tumorigenesis of many human cancers, including multiple carcinomas, melanoma, and lymphoma.
Yan-Ping Li, Wen-Ze Wang, Xue-Qi Chen, Ling-Bo Li, Zhi-Yong Liang, Kun Ru, Jing-Nan Li   +6 more
doaj   +1 more source

Significance of Des-gamma-carboxy Prothrombin Production in Hepatocellular Carcinoma [PDF]

, 2009
Serum des-gamma-carboxy prothrombin (DCP) is commonly used to detect hepatocellular carcinoma (HCC). This review focuses on the clinical features of DCP-positive HCC and the molecular function of DCP in HCC.
Fujikawa, Tatsuya, Shiraha, Hidenori, Yamamoto, Kazuhide   +2 more
core   +1 more source