The crosstalk between STAT3 and microRNA in cardiac diseases and protection
Frontiers in Cardiovascular Medicine, 2022 Signal transducer and activator of transcription 3 (STAT3), an important transcription factor and signaling molecule, play an important role in cardiac disease and protection. As a transcription factor, STAT3 upregulates anti-oxidative and anti-apoptotic
Lan Wu +4 more
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Targeting STAT3 in Cancer with Nucleotide Therapeutics. [PDF]
, 2019 Signal transducer and activator of transcription 3 (STAT3) plays a critical role in promoting the proliferation and survival of tumor cells. As a ubiquitously-expressed transcription factor, STAT3 has commonly been considered an "undruggable" target for ...
Grandis, Jennifer R +3 more
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DENDRITIC CELL DIFFERENTIATION BLOCKED BY PRIMARY EFFUSION LYMPHOMA-RELEASED FACTORS IS PARTIALLY RESTORED BY INHIBITION OF P38 MAPK [PDF]
, 2010 To better understand the molecular mechanisms underlying the dendritic cell (DC) defects in cancer, we analyzed which signaling pathway is implicated in the abnormal monocyte differentiation into DC determined by the presence of Primary effusion lymphoma
CIRONE, Mara +6 more
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STAT3 gain-of-function mutation in a patient with pulmonary Mycobacterium abscessus infection
Respiratory Medicine Case Reports, 2020 Background: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor involved in cellular proliferation, apoptosis, and differentiation.
Miguel S. Gonzalez-Mancera +2 more
doaj +1 more source
FGFR1 Cooperates with EGFR in Lung Cancer Oncogenesis, and Their Combined Inhibition Shows Improved Efficacy [PDF]
, 2019 Introduction: There is substantial evidence for the onco- genic effects of fi broblast growth factor receptor 1 (FGFR1) in many types of cancer, including lung cancer, but the role of this receptor has not been addressed speci fi cally in lung ...
Carnero Moya, Amancio +11 more
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The relationship between microRNAs and the STAT3-related signaling pathway in cancer
Tumor Biology, 2017 MicroRNAs are non-coding RNAs that regulate gene expression by targeting messenger RNA molecules in 3′ untranslated region. Mounting evidence indicates that microRNAs regulate several factors to influence various biological activities that are related to
Lin Zhang +7 more
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Pharmaceuticals, 2021 Multidrug resistance (MDR), for which the mechanisms are not yet fully clear, is one of the major obstacles to cancer treatment. In recent years, signal transducer and activator of transcription 3 (STAT3) were found to be one of the important MDR ...
Ko-Hua Yu +7 more
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Epithelial sodium channel is a key mediator of growth hormone-induced sodium retention in acromegaly.: Antinatriuretic action of growth hormone [PDF]
, 2008 International audienceAcromegalic patients present with volume expansion and arterial hypertension, but the renal sites and molecular mechanisms of direct antinatriuretic action of GH remain unclear.
Blanchard, Anne +8 more
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Structure, function and inhibition of poly(ADP-ribose)polymerase, member 14 (PARP14) [PDF]
, 2018 Poly(ADP-ribose)polymerase, member 14 (PARP14, alternatively named ARTD8, BAL2, and COAST6) is an intracellular mono(ADP-ribosyl) transferase. PARP14 transfers a negatively charged ADP-ribose unit from a donor NAD+ molecule onto a target protein, post ...
Levonis, Stephan M +3 more
core +1 more source
Aberrant activation of signal transducer and activator of transcription-3 (STAT3) signaling in endometriosis [PDF]
Human Reproduction, 2015 Are STAT3 signaling molecules differentially expressed in endometriosis?
Byung Gak, Kim +9 more
openaire +2 more sources