Results 21 to 30 of about 98,037 (252)

Indole-3-carbinol induces apoptosis of chronic myelogenous leukemia cells through suppression of STAT5 and Akt signaling pathways

Tumor Biology, 2017
Signal transducer and activator of transcription 5 and Akt pathways, implicated in signaling transduction downstream of BCR–ABL, play critical roles in the pathogenesis of chronic myeloid leukemia.
Majid Safa, Leila Jafari, Fatemeh Alikarami, Rima Manafi Shabestari, Ahmad Kazemi   +4 more
doaj   +1 more source

Kynurenine–PARP-1 Link Mediated by MicroRNA 210 May Be Dysregulated in Pulmonary Hypertension

Anatolian Journal of Cardiology, 2022
Background: Dysregulation of microRNAs is associated with pulmonary hypertension. The present study aimed to determine the alterations in microRNA and microRNA expressions and their role in signaling pathways and investigate the relationship with serum ...
Alperen Emre Akgun, Yalın Tolga Yaylalı, Mücahit Seçme, Yavuz Dodurga, Hande Şenol   +4 more
doaj   +1 more source

A Sticky Story for Signal Transducer and Activator of Transcription 3 in Platelets [PDF]

Circulation, 2013
The signal transducer and activator of transcription 3 (STAT3) is a cytoplasmic protein that, on appropriate signaling, translocates to the nucleus and binds DNA response elements of target genes.1 As a result, STAT3 mediates the transcription of key mediators involved in mitogenesis, cell survival, apoptosis, cell cycle regulation, angiogenesis, and ...
Karin, Chen, Matthew T, Rondina, Andrew S, Weyrich   +2 more
openaire   +2 more sources

Signal Transducer and Activator of Transcription-3 Modulation of Cardiac Pathology in Chronic Chagasic Cardiomyopathy

Frontiers in Cellular and Infection Microbiology, 2021
Chronic Chagasic cardiomyopathy (CCC) is a severe clinical manifestation that develops in 30%–40% of individuals chronically infected with the protozoal parasite Trypanosoma cruzi and is thus an important public health problem.
Kristyn A. Hoffman, Kristyn A. Hoffman, Maria Jose Villar, Maria Jose Villar, Cristina Poveda, Cristina Poveda, Maria Elena Bottazzi, Maria Elena Bottazzi, Maria Elena Bottazzi, Maria Elena Bottazzi, Peter J. Hotez, Peter J. Hotez, Peter J. Hotez, Peter J. Hotez, David J. Tweardy, Kathryn M. Jones, Kathryn M. Jones, Kathryn M. Jones   +17 more
doaj   +1 more source

Anti-Interferon-γ Autoantibodies Impair T-Lymphocyte Responses in Patients with Talaromyces marneffei Infections

Infection and Drug Resistance, 2022
Zhao-Ming Chen,1,* Xiao-Yun Yang,1,2,* Zheng-Tu Li,1,* Wei-Jie Guan,1,3 Ye Qiu,4 Shao-Qiang Li,1 Yang-Qing Zhan,1 Zi-Ying Lei,5 Jing Liu,4 Jian-Quan Zhang,6 Zhong-Fang Wang,1,2 Feng Ye1 1State Key Laboratory of Respiratory Disease, National ...
Chen ZM, Yang XY, Li ZT, Guan WJ, Qiu Y, Li SQ, Zhan YQ, Lei ZY, Liu J, Zhang JQ, Wang ZF, Ye F   +11 more
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Bilateral Superior Cervical Sympathectomy Activates Signal Transducer and Activator of Transcription 3 Signal to Alleviate Myocardial Ischemia-Reperfusion Injury

Frontiers in Cardiovascular Medicine, 2022
BackgroundThere is growing evidence about the effect of bilateral superior cervical sympathectomy on myocardial ischemia-reperfusion (I/R) injury. Studies have increasingly found that the signal transducer and activator of transcription 3 (STAT3) plays a
Lixia Li, Jiahong Gao, Lin Gao, Le Li, Hongfei Zhang, Wei Zhao, Shiyuan Xu   +6 more
doaj   +1 more source

STAT3 (signal transducer and activator of transcription 3) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on STAT3 (signal transducer and activator of transcription 3), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +1 more source

Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Transducer and Activator of Transcription and Epidermal Growth Factor Receptor Inhibition

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundMost novel cancer therapeutics target kinases that are essential to tumor survival. Some of these kinase inhibitors are associated with cardiotoxicity, whereas others appear to be cardiosafe.
Timothy J. Stuhlmiller, Jon S. Zawistowski, Xin Chen, Noah Sciaky, Steven P. Angus, Sean T. Hicks, Traci L. Parry, Wei Huang, Ju Youn Beak, Monte S. Willis, Gary L. Johnson, Brian C. Jensen   +11 more
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Signal Transducer and Activator of Transcription‐3, Inflammation, and Cancer [PDF]

Annals of the New York Academy of Sciences, 2009
Signal transducer and activator of transcription‐3 (STAT‐3) is one of six members of a family of transcription factors. It was discovered almost 15 years ago as an acute‐phase response factor. This factor has now been associated with inflammation, cellular transformation, survival, proliferation, invasion, angiogenesis, and metastasis of cancer ...
Harikumar, Kuzhuvelil B., Gupta, Shan R., Aggarwal, Bharat B., Kunnumakkara, Ajaikumar B., Sung, Bokyung, Koca, CEMİLE, Dey, Sanjit, Tharakan, Sheeja T.   +7 more
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Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses

Frontiers in Immunology, 2018
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated downstream of many key cytokine receptors expressed by lymphocytes.
Elissa K. Deenick, Elissa K. Deenick, Simon J. Pelham, Simon J. Pelham, Alisa Kane, Alisa Kane, Alisa Kane, Alisa Kane, Cindy S. Ma, Cindy S. Ma   +9 more
doaj   +1 more source