Results 11 to 20 of about 98,037 (252)

Signal Transducer and Activator of Transcription 3 Mutation with Invasive Eosinophilic Disease

Allergy & Rhinology, 2012
Hyper-IgE syndrome (HIES), or Jobs disease, is a rare immunologic disorder characterized by the triad of staphylococcal abscesses, pneumonia with pneumatocele formation, and elevated IgE. It has been shown to have multiple modes of inheritance, autosomal
Kara Crosby D.O., David Swender D.O., Leah Chernin D.O., Said Hafez-Khayyata, Hans Ochs M.D., Haig Tcheurekdjian M.D., Robert Hostoffer D.O.   +6 more
doaj   +3 more sources

Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma [PDF]

Respiratory Research, 2005
Background Identifying genetic determinants for lung function is important in providing insight into the pathophysiology of asthma. Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is ...
Lazarus Ross, Lake Stephen, Tantisira Kelan G, Litonjua Augusto A, Richter Brent G, Gabriel Stacey, Silverman Eric S, Weiss Scott T   +7 more
doaj   +6 more sources

Signal transducer and activator of transcription 3 [PDF]

Current Opinion in Hematology, 2016
Signal transducer and activator of transcription 3 (STAT3) is an important transcription factor involved in a wide variety of cellular functions. Germline loss-of-function mutations are known to cause hyper-IgE immunodeficiency (autosomal dominant hyper IgE syndrome), whereas somatic gain-of-function mutations have been described in large granular cell
Lisa R, Forbes, Josh, Milner, Elie, Haddad   +2 more
openaire   +3 more sources

S-Glutathionylation Impairs Signal Transducer and Activator of Transcription 3 Activation and Signaling [PDF]

Endocrinology, 2008
S-glutathionylation is a physiological, reversible protein modification of cysteine residues with glutathione in response to mild oxidative stress. Because the key cell growth regulator signal transducer and activator of transcription (STAT) 3 is particularly susceptible to redox regulation, we hypothesized that oxidative modification of cysteine ...
Yi, Xie, Sutapa, Kole, Patricia, Precht, Michael J, Pazin, Michel, Bernier   +4 more
openaire   +2 more sources

Aberrant activation of signal transducer and activator of transcription-3 (STAT3) signaling in endometriosis [PDF]

Human Reproduction, 2015
Are STAT3 signaling molecules differentially expressed in endometriosis?
Byung Gak, Kim, Jung-Yoon, Yoo, Tae Hoon, Kim, Jung-Ho, Shin, John F, Langenheim, Susan D, Ferguson, Asgerally T, Fazleabas, Steven L, Young, Bruce A, Lessey, Jae-Wook, Jeong   +9 more
openaire   +2 more sources

Activated Signal Transducer and Activator of Transcription (STAT) 3 [PDF]

Cancer Research, 2004
Abstract Constitutive activation of the Janus-activated kinase/signal transducer and activator of transcription (STAT) pathway promotes the proliferation and survival of cancer cells in culture and is associated with various cancers, including those of the ovary.
Debra L. Silver, Honami Naora, Jinsong Liu, Wenjun Cheng, Denise J. Montell   +4 more
openaire   +1 more source

Regulation and function of signal transducer and activator of transcription 3

World Journal of Biological Chemistry, 2014
Laparoscopic surgery is the main treatment method for patients with gastrointestinal malignant tumors. Although laparoscopic surgery is minimally invasive, its tool stimulation and pneumoperitoneum pressure often cause strong stress reactions in patients. On the other hand, gastrointestinal surgery can cause stronger pain in patients, compared to other
Qian-Rong, Qi, Zeng-Ming, Yang
openaire   +2 more sources

The Roles of Signal Transducer and Activator of Transcription 3 in Tumor Metastasis

Chinese Journal of Lung Cancer, 2010
Lei GONG, Zhihao WU, Qinghua ZHOU
doaj   +2 more sources

Upregulation of signal transducer and activator of transcription 3 in dogs with chronic inflammatory enteropathies

Journal of Veterinary Internal Medicine, 2021
Background In inflammatory bowel disease (IBD) in humans, phosphorylated signal transducer and activator of transcription 3 (pSTAT3) is upregulated in mucosal epithelial cells and correlates with clinical severity. Hypothesis/Objective To investigate the
Anita Manz, Karin Allenspach, Stefan Kummer, Barbara Richter, Ingrid Walter, Sabine Macho‐Maschler, Alexander Tichy, Iwan A Burgener, Nicole Luckschander‐Zeller   +8 more
doaj   +1 more source

Chemoreversal Agents from Taiwanofungus Genus and Their More Potent Methyl Derivatives Targeting Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation

Pharmaceuticals, 2021
Multidrug resistance (MDR), for which the mechanisms are not yet fully clear, is one of the major obstacles to cancer treatment. In recent years, signal transducer and activator of transcription 3 (STAT3) were found to be one of the important MDR ...
Ko-Hua Yu, Chin-Chuan Hung, Tian-Shung Wu, Chin-Fu Chen, I-Ting Wu, Ping-Chung Kuo, Sio-Hong Lam, Hsin-Yi Hung   +7 more
doaj   +1 more source