Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis [PDF]
Journal of Allergy and Clinical Immunology, 2016 During IgE-mediated immediate hypersensitivity reactions, vascular endothelial cells permeabilize in response to mast cell mediators. We have demonstrated previously that patients and mice with signal transducer and activator of transcription 3 (STAT3) mutations (autosomal dominant hyper-IgE syndrome [AD-HIES]) are partially protected from anaphylaxis ...
Valerie, Hox +13 more
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Signal Transducer and Activator of Transcription 3 [PDF]
Current Opinion in Hematology, 2016 Signal transducer and activator of transcription 3 (STAT3) is an important transcription factor involved in a wide variety of cellular functions. Germline loss-of-function mutations are known to cause hyper-IgE immunodeficiency (autosomal dominant hyper IgE syndrome), whereas somatic gain-of-function mutations have been described in large granular cell
Lisa R, Forbes +2 more
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NT157 Inhibits HCC Migration via Downregulating the STAT3/Jab1 Signaling Pathway
Technology in Cancer Research & Treatment, 2021 Purpose: The high fatality-to-case ratio of hepatocellular carcinoma is directly related to metastasis. The signal transducer and activator of transcription-3 is a key mediator of the cytokine and growth factor signaling pathways and drives the ...
SiZhe Yu +7 more
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S-Glutathionylation Impairs Signal Transducer and Activator of Transcription 3 Activation and Signaling [PDF]
Endocrinology, 2008 S-glutathionylation is a physiological, reversible protein modification of cysteine residues with glutathione in response to mild oxidative stress. Because the key cell growth regulator signal transducer and activator of transcription (STAT) 3 is particularly susceptible to redox regulation, we hypothesized that oxidative modification of cysteine ...
Yi, Xie +4 more
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Special Issue “Role of STAT3 in Oncogenesis”
Biomedicines, 2022 This Biomedicines Special Issue was designed to attract articles that focused on the pleiotropic role of the signal transducer and activator of transcription 3 (STAT3) transcription factor in different facets of tumorigenesis [...]
Kwang Seok Ahn
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Clinicopathological significance of protein disulphide isomerase A3 and phosphorylated signal transducer and activator of transcription 3 in cervical carcinoma [PDF]
Contemporary OncologyAsmaa Abdullatif +7 more
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Activated Signal Transducer and Activator of Transcription (STAT) 3 [PDF]
Cancer Research, 2004 Abstract Constitutive activation of the Janus-activated kinase/signal transducer and activator of transcription (STAT) pathway promotes the proliferation and survival of cancer cells in culture and is associated with various cancers, including those of the ovary.
Debra L. Silver +4 more
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Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications. [PDF]
, 2014 Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival.
Bonavida, Benjamin, Shvartsur, Anna
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Galectin-12 in Cellular Differentiation, Apoptosis and Polarization. [PDF]
, 2018 Galectin-12 is a member of a family of mammalian lectins characterized by their affinity for β-galactosides and consensus amino acid sequences. The protein structure consists of a single polypeptide chain containing two carbohydrate-recognition domains ...
Liu, Fu-Tong, Wan, Lei, Yang, Ri-Yao
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The transcription factor Etv5 controls TH17 cell development and allergic airway inflammation [PDF]
, 2014 Background The differentiation of TH17 cells, which promote pulmonary inflammation, requires the cooperation of a network of transcription factors. Objectives We sought to define the role of Etv5, an Ets-family transcription factor, in TH17 cell ...
Kaplan, Mark H. +3 more
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