Results 51 to 60 of about 146,182 (290)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Oncostatin M receptor β deficiency attenuates atherogenesis by inhibiting JAK2/STAT3 signaling in macrophages

Journal of Lipid Research, 2017
Oncostatin M (OSM) is a secreted cytokine mainly involved in chronic inflammatory and cardiovascular diseases through binding to OSM receptor β (OSMR-β).
Xin Zhang, Jing Li, Juan-Juan Qin, Wen-Lin Cheng, Xueyong Zhu, Fu-Han Gong, Zhigang She, Zan Huang, Hao Xia, Hongliang Li   +9 more
doaj   +1 more source

Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma [PDF]

, 2015
published_or_final_versio
Bae, SS, Choi, KJ, Factor, VM, Jang, JJ, Jeong, JM, Jeong, WI, Kim, BH, Kim, EK, Kim, TW, Lee, JH, Lee, YH, Ma, SKY, Park, IC, Thorgeirsson, SS, Won, C, Ye, SK, Yi, EH, Yoon, JH   +17 more
core   +1 more source

Regulation and function of signal transducer and activator of transcription 3

World Journal of Biological Chemistry, 2014
Laparoscopic surgery is the main treatment method for patients with gastrointestinal malignant tumors. Although laparoscopic surgery is minimally invasive, its tool stimulation and pneumoperitoneum pressure often cause strong stress reactions in patients. On the other hand, gastrointestinal surgery can cause stronger pain in patients, compared to other
Qian-Rong, Qi, Zeng-Ming, Yang
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Construction and characterization of mice with conditional knockout of Stat3 gene in microglia

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To construct mice with conditional knockout of Stat3 gene in microglia based on the Cre-Loxp system and validate their knockout efficiency.Methods·Cx3cr1creERT2 and Stat3fl/fl genotypic mice were bred for conditional knockout mice (CKO) and ...
ZHU Xiaochen, XIE Xinyi, ZHAO Xuri, XU Lina, HE Zhiyan, ZHOU Wei   +5 more
doaj   +1 more source

Definition of a family of tissue-protective cytokines using functional cluster analysis: a proof-of-concept study [PDF]

, 2014
The discovery of the tissue-protective activities of erythropoietin (EPO) has underlined the importance of some cytokines in tissue-protection, repair, and remodeling.
Annenkov, Alexander, Ermilov, Peter, Ghezzi, Pietro, Mengozzi, Manuela, Pearl, Frances   +4 more
core   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

GdX inhibits the occurrence and progression of breast cancer by negatively modulating the activity of STAT3

Cancer Biology & Therapy
Aim To elucidate the biological functionality and regulatory mechanisms of GdX in breast cancer (BC).Methods The examination of GdX expression in human BC tissues and cell lines was conducted through immunohistochemical (IHC) and Western blot.
Zhilin Chen, Lu Xu, Shibin Lin, Hongjun Huang, Qing Long, Jiwei Liu   +5 more
doaj   +1 more source

Expression of Signal Transducer and Activator of Transcription 3 and Suppressor of Cytokine Signaling 3 in Urothelial Carcinoma

Kaohsiung Journal of Medical Sciences, 2009
In this study, we investigated the expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) Tyr705 and suppressor of cytokine signaling 3 (SOCS3) in urothelial carcinoma (UC).
Wan-Ting Huang, Sheau-Fang Yang, Chun-Chieh Wu, Wan-Tzu Chen, Ya-Chun Huang, Yue-Chiu Su, Chee-Yin Chai   +6 more
doaj   +1 more source