Results 41 to 50 of about 31,567 (277)
Hepatology, EarlyView., 2022 IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu +20 more
wiley +1 more source
Targeting Upstream Janus Kinases [PDF]
, 2016 Janus kinases (JAKs) are the tyrosine kinases that are the principal activators of STAT proteins – particularly downstream of cytokine receptors – during normal development and homeostasis.
Parisa Rasighaemi (13090413) +1 more
core +2 more sources
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Pharmaceutical Biology, 2022 Context Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disease that is closely related to inflammation and apoptosis. The traditional Chinese medicine compound preparation Huangqin decoction (HQD) has been widely used in the clinical ...
Xiaowei Mo +6 more
doaj +1 more source
Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis
Hepatology, EarlyView., 2022 Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres +21 more
wiley +1 more source
Problems of pain and quality of life in rheumatoid arthritis: focus on baricitinib
Научно-практическая ревматология, 2020 Modern therapy for rheumatoid arthritis (RA) allows not only to reduce the activity of immune-mediated inflammation and slow down the progression of the disease, but also to quickly eliminate the main symptoms that cause the most concern to patients ...
A. E. Karateev
doaj +1 more source
Upadacitinib for the treatment of psoriatic arthritis
Drugs in Context, 2023 Psoriatic arthritis is a chronic systemic inflammatory disease that presents with a variable clinical course and is typically associated with joint inflammation, together with cutaneous psoriasis.
Diogo Fonseca +2 more
doaj +1 more source
Janus kinases affect thrombopoietin receptor cell surface localization and stability. [PDF]
, 2005 The thrombopoietin receptor (TpoR) regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. TpoR signals by activating Janus kinases JAK2 and Tyk2.
Royer, Yohan +4 more
core +1 more source
Janus kinases 1 and 2 regulate chemokine-mediated integrin activation and naïve T-cell homing. [PDF]
, 2013 Janus kinases (JAKs) are central signaling molecules in cytokine receptor cascades. Although they have also been implicated in chemokine receptor signaling, this function continues to be debated.
Graciela Cascio +23 more
core +1 more source
Arquivos de GastroenterologiaJanus kinases inhibitors have already been incorporated into the management of immune-mediated diseases, such as rheumatoid arthritis, and are being investigated for the treatment of psoriasis and inflammatory bowel diseases, both ulcerative colitis and ...
Fábio Vieira TEIXEIRA +2 more
doaj +1 more source