Results 31 to 40 of about 31,567 (277)

Janus kinases and Src family kinases in the regulation of EGF-induced vimentin expression in MDA-MB-468 breast cancer cells [PDF]

, 2016
Epithelial-mesenchymal transition (EMT) is an important process associated with the metastasis of breast cancer cells. Members of the Janus kinases (JAKs) and Src family kinases (SFKs) are implicated in the regulation of an invasive phenotype in various ...
Brooks, Andrew J., Thompson, Erik W., Monteith, Gregory R., Roberts-Thomson, Sarah J., Stewart, Teneale A., Azimi, Iman   +5 more
core   +3 more sources

JAK-Inhibitors for the Treatment of Rheumatoid Arthritis: A Focus on the Present and an Outlook on the Future

Biomolecules, 2020
Janus kinase inhibitors (JAKi) belong to a new class of oral targeted disease-modifying drugs which have recently revolutionized the therapeutic panorama of rheumatoid arthritis (RA) and other immune-mediated diseases, placing alongside or even replacing
Jacopo Angelini, Rossella Talotta, Rossana Roncato, Giulia Fornasier, Giorgia Barbiero, Lisa Dal Cin, Serena Brancati, Francesco Scaglione   +7 more
doaj   +1 more source

A comparison of Janus kinase inhibitor safety in rheumatoid arthritis [PDF]

, 2021
The last decade has seen considerable advancement in the treatment options available to patients with rheumatoid arthritis (RA) through the development of oral, small molecules that target and inhibit Janus kinases (JAKi).
Marabani, Mona, Mona Marabani, Lim, Irwin, Irwin Lim, Peter Nash, Nash, Peter   +5 more
core   +1 more source

Inhibiteurs des Janus kinases  : nouvelles perspectives pour la médecine de précision  ? [PDF]

, 2022
Janus kinase inhibitors (JAKi), such as tofacitinib, baricitinib, upadacitinib or ruxolitinib, are small molecules active on specific intracellular targets and used orally for the treatment of autoimmune or myeloproliferative diseases.
Ribi, Camillo, Chalandon, Yves, Grandoni, F., Grandoni, Francesco, Chalandon, Y., Dumusc, A., Dumusc, Alexandre, Tachet, J., Girardin, François, Buclin, T., Ribi, C., Conrad, C., Conrad, Curdin, Girardin, F., Tachet, Jérémie, Buclin, Thierry   +15 more
core   +1 more source

JAK inhibitors ∼ overview∼

Immunological Medicine, 2023
Among various tyrosine kinases, a family of Janus kinases (JAK) has been elucidated as key players in signal transduction from vital cytokine receptors, such as interleukins and interferons.
Hideto Kameda
doaj   +1 more source

The Jak/STAT signaling pathway is downregulated at febrile temperatures. [PDF]

PLoS ONE, 2012
BACKGROUND: The Janus family of kinases (JAKs), Jak1, Jak2, Jak3, and Tyk2, constitute a subgroup of non-receptor protein tyrosine kinases. Upon cytokine binding, the receptor-associated kinases are activated and phosphorylate tyrosine residues in their ...
Tobias Nespital, Ger J Strous
doaj   +1 more source

Updated American College of Rheumatology/American Association of Hip and Knee Surgeons guideline for the perioperative management of antirheumatic medication in patients with rheumatic diseases undergoing elective total hip or total knee arthroplasty 2022

Научно-практическая ревматология, 2023
The article presents updated guidelines developed by the American College of Rheumatology and the American Association of Hip and Knee Surgeons on the perioperative treatment of patients with rheumatoid arthritis, ankylosing spondylitis, psoriatic ...
V. N. Amirjanova, M. A. Makarov, A. E. Karateev, A. E. Khramov, S. V. Maglevaniy, A. V. Rozov, V. A. Nesterenko, E. L. Nasonov   +7 more
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Role of Janus-Kinases in Major Depressive Disorder

Neurosignals, 2016
Background/Aims: Major depressive disorder is a severe, common and often chronic disease with a significant mortality due to suicide. The pathogenesis of major depression is still unknown. It is assumed that a reduction of neurogenesis in the hippocampus
Anne Gulbins, Heike Grassmé, Richard Hoehn, Marcus Kohnen, Michael J. Edwards, Johannes Kornhuber, Erich Gulbins   +6 more
doaj   +1 more source

Janus Kinase Inhibitors and Cell Therapy [PDF]

Frontiers in Immunology, 2021
Cellular therapies such as allogeneic hematopoietic stem cell transplantation (HSCT) and immune-effector cell therapy (IECT) continue to have a critical role in the treatment of patients with high risk malignancies and hematologic conditions. These therapies are also associated with inflammatory conditions such as graft-versus-host disease (GVHD) and ...
Amer Assal, Markus Y. Mapara, Markus Y. Mapara   +2 more
openaire   +3 more sources