Results 1 to 10 of about 30,393,220 (286)

Janus kinase-1 and 3 in ankylosing spondylitis

Journal of the Formosan Medical Association, 2019
Background/purpose: To investigate the Janus kinase-1 and 3 (JAK-1 and 3) expression in peripheral blood mononuclear cells (PBMCs) in ankylosing spondylitis (AS). Methods: The levels of JAK-1 and JAK-3 mRNA in PBMCs, CD3+ T cells and CD14+ monocytes were
Hsien-Tzung Liao, Tzu-Hao Li, Chun-Hsiung Chen, Hung-An Chen, Wei-Sheng Chen, Chien-Chih Lai, Chung-Tei Chou, Chang-Youh Tsai   +7 more
doaj   +4 more sources

Immunohistochemistry of Janus Kinase 1 (JAK1) Expression in Vitiligo [PDF]

Journal of Pathology and Translational Medicine, 2018
Background Vitiligo is a chronic autoimmune disease in which the destruction of melanocytes causes white spots on the affected skin. Janus kinase (JAK) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals ...
Asmaa Gaber Abdou, Alaa Maraee, Hossam Yassien, Mona Sarhan   +3 more
doaj   +5 more sources

Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression [PDF]

Cell Reports, 2018
Summary: Janus kinases (JAKs) and their downstream STAT proteins play key roles in cytokine signaling, tissue homeostasis, and cancer development. Using a breast cancer model that conditionally lacks Janus kinase 1, we show here that JAK1 is essential ...
Barbara L. Wehde, Patrick D. Rädler, Hridaya Shrestha, Stevi J. Johnson, Aleata A. Triplett, Kay-Uwe Wagner   +5 more
doaj   +4 more sources

Evaluation of immunohistochemical and gene expression of Janus kinase 1 and Janus kinase 3 in the skin of different clinical types of mycosis fungoides patients - Part I [PDF]

Anais Brasileiros de Dermatologia
Background Mycosis fungoides is the commonest type of cutaneous T-Cell lymphoma. Janus kinases are intracellular tyrosine kinases that have recently been proven to have a crucial role in the pathogenesis and progression of several dermatological and ...
Heba Saed El-Amawy, Basma Mourad Mohamed Ali, Mohamed Moustafa Shareef, Lamia Elgarhy   +3 more
doaj   +6 more sources

The Janus kinase 1 is critical for pancreatic cancer initiation and progression [PDF]

Cell Reports
Summary: Interleukin-6 (IL-6)-class inflammatory cytokines signal through the Janus tyrosine kinase (JAK)/signal transducer and activator of transcription (STAT) pathway and promote the development of pancreatic ductal adenocarcinoma (PDAC); however, the
Hridaya Shrestha, Patrick D. Rädler, Rayane Dennaoui, Madison N. Wicker, Nirakar Rajbhandari, Yunguang Sun, Amy R. Peck, Kerry Vistisen, Aleata A. Triplett, Rafic Beydoun, Esta Sterneck, Dieter Saur, Hallgeir Rui, Kay-Uwe Wagner   +13 more
doaj   +4 more sources

Association of Janus kinase 1 and 2 expression with clinical indices in diabetic kidney disease [PDF]

Journal of Research in Medical Sciences
Background: Diabetic Kidney Disease (DKD) is a prevalent complication of uncontrolled hyperglycemia that imposes a considerable burden on the health system due to the need for renal replacement therapy in the long term.
Mahboobeh Freidoon, Naghmeh Sayadi, Sara Assadiasl, Hadi Kazemzadehghadim, Narjes Soleimanifar, Maryam Sadr, Hanieh Mojtahedi, Maryam Ahmadi, Mohammad Hossein Nicknam   +8 more
doaj   +2 more sources

Ruxolitinib suppresses liver fibrosis progression and accelerates fibrosis reversal via selectively targeting Janus kinase 1/2 [PDF]

Journal of Translational Medicine, 2022
Background JAK1 and JAK2 have been implicated in fibrosis and cancer as a fibroblast-related marker; however, their role in liver fibrosis has not been elucidated.
Zhenghui Song, Xinhui Liu, Wan Zhang, Yue Luo, Hua Xiao, Yun Liu, Guanqi Dai, Jian Hong, Aimin Li   +8 more
doaj   +2 more sources

Ruxolitinib: An Oral Janus Kinase 1 and Janus Kinase 2 Inhibitor in the Management of Myelofibrosis [PDF]

Postgraduate Medicine, 2013
Myelofibrosis (MF), polycythemia vera (PV), and essential thrombocythemia (ET) are referred to as the classic Philadelphia chromosome (BCR-ABL1)-negative myeloproliferative neoplasms. Although each has distinct pathologic features, all 3 display alterations in Janus kinase (JAK) signal transduction activator of transcription signaling. Myelofibrosis is
Srdan Verstovsek
exaly   +3 more sources

Evaluation of immunohistochemical and gene expression of Janus kinase 1 and Janus kinase 3 in the skin of different clinical types of mycosis fungoides patients - Part II: reverse transcriptase-polymerase chain reaction [PDF]

Anais Brasileiros de Dermatologia
Background Mycosis Fungoides (MF) is the commonest type of primary cutaneous T-Cell lymphomas representing about 50% of all lymphomas arising primarily in the skin. Janus kinases are non-receptor intracellular tyrosine kinases that play an important role
Heba Saed El-Amawy, Basma Mourad Mohamed Ali, Mohamed Labib Salem, Lamia Elgarhy   +3 more
doaj   +3 more sources

The Janus kinase 1/2 inhibitor ruxolitinib in COVID-19. [PDF]

Leukemia, 2020
La Rosee F, Bremer HC, Gehrke I, Kehr A, Hochhaus A, Birndt S, et al. The Janus kinase 1/2 inhibitor ruxolitinib in COVID-19 with severe systemic hyperinflammation. Leukemia. 2020;34:1805–15. https://doi.org/10.1038/s41375-020-0891-0. CAS Article PubMed Google Scholar Download references Division of Hematology, University of Siena, Siena, Italy ...
Gozzetti A, Capochiani E, Bocchia M.
europepmc   +6 more sources