Results 11 to 20 of about 73,942 (286)
Successful Treatment of Severe Nail Lichen Planus with Janus Kinase 1 Inhibitor Abrocitinib [PDF]
Clinical, Cosmetic and Investigational DermatologyYingzhi Luo,1,* Jian Wu,2,* Xingyun Zhao,1,* Ping Yang,1 Yunmi Qiu,1 Liming Wu,1 Jianbo Zhong1 1Department of Dermatology, Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University, Hangzhou, Zhejiang ...
Luo Y +6 more
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on JAK1 (Janus kinase 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Knoops, L, Hornakova, T, Renauld, JC
openaire +3 more sources
Janus kinase inhibitors: jackpot or potluck?
Oncology Reviews, 2012 The reports of a unique mutation in the Janus kinase-2 gene (JAK2) in polycythemia vera by several independent groups in 2005 quickly spurred the development of the Janus kinase inhibitors.
Pavithran Keechilat +1 more
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IL-17A Damages the Blood–Retinal Barrier through Activating the Janus Kinase 1 Pathway [PDF]
Biomedicines, 2021 Blood–retinal barrier (BRB) dysfunction underlies macular oedema in many sight-threatening conditions, including diabetic macular oedema, neovascular age-related macular degeneration and uveoretinitis.
Eimear M. Byrne +5 more
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Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1 [PDF]
Cancers, 2019 Janus kinases (JAKs) are found constitutively associated with cytokine receptors and are present in an inactive state prior to cytokine exposure. Activating mutations of JAKs are causative for a number of leukemias, lymphomas, and myeloproliferative diseases.
Nicholas P. D. Liau +6 more
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miR‑20a‑5p inhibits endometrial cancer progression by targeting janus kinase 1 [PDF]
Oncology Letters, 2021 Endometrial cancer (EC) is a multi-factorial disease of which pathogenesis has not been fully elucidated. The function and underlying mechanism of microRNA-20a-5p (miR-20a-5p) in EC remain poorly understood. The present study aimed to analyze the association between miR-20a-5p expression and the clinicopathological characteristics of patients with EC ...
He, Ying +4 more
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Nature Communications, 2021 Increased risk of premature cardiovascular disease in systemic lupus erythematosus (SLE) is not well understood, but in animal models, the Janus kinase inhibitor tofacitinib improves related phenotypes.
Sarfaraz A. Hasni +38 more
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Untangle a Broken Heart via Janus Kinase 1 [PDF]
Circulation Research, 2017 Protein homeostasis and quality control, as balanced by synthesis and degradation, is critical to cellular health and normal cardiac function. Similar to amyloid-related neurodegenerative diseases, the familial forms of amyloid cardiomyopathy are characterized by protein aggregate accumulation in cardiomyocytes.
Chen, Gao, Yibin, Wang
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Successful treatment of pyoderma gangrenosum with Janus kinase 1/2 inhibition
JEADV Clinical Practice, 2022 Pyoderma gangrenosum (PG) is a rare, autoinflammatory disease leading to painful, hard‐to‐treat ulcers. Besides systemic glucocorticoids, a plethora of classic immunosuppressants, biologics and small molecules have been reported to improve PG disease ...
Sebastian Sitaru +2 more
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Acta Dermato-VenereologicaThe European Medicines Agency recently limited the use of oral Janus kinase inhibitors in certain patient populations, including those with atopic dermatitis.
Ida Vittrup +4 more
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