Results 41 to 50 of about 73,942 (286)

Clinical-economic analysis of the target therapy in severe atopic dermatitidis in adults

Качественная клиническая практика, 2022
Target therapy of severe atopic dermatitidis (AD) is actual because AD has a high prevalence and social-economic burden. Target therapy consists of monoclonal antibodies (dupilumab) as well as janus kinase inhibitors (upadacitinib and baricitinib).
A. S. Kolbin, Y. M. Gomon, M. A. Proskurin, Y. E. Balikina   +3 more
doaj   +1 more source

Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling [PDF]

Molecular and Cellular Biology, 2016
Despite a wealth of knowledge about the significance of individual signal transducers and activators of transcription (STATs), essential functions of their upstream Janus kinases (JAKs) during postnatal development are less well defined. Using a novel mammary gland-specific JAK1 knockout model, we demonstrate here that this tyrosine kinase is essential
Kazuhito, Sakamoto, Barbara L, Wehde, Kyung Hyun, Yoo, Taemook, Kim, Nirakar, Rajbhandari, Ha Youn, Shin, Aleata A, Triplett, Patrick D, Rädler, Fabian, Schuler, Andreas, Villunger, Keunsoo, Kang, Lothar, Hennighausen, Kay-Uwe, Wagner   +12 more
openaire   +2 more sources

In vivo and ex vivo regulation of visfatin production by leptin in human and murine adipose tissue : role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways [PDF]

, 2009
Visfatin is an adipogenic adipokine with increased levels in obesity, properties common to leptin. Thus, leptin may modulate visfatin production in adipose tissue (AT).
Brown, James, Clifford J. Bailey, Jing Chen, Bee K. Tan, Tan, Bee K., Bailey, C. J. (Clifford J.), Adya, Raghu, Randeva, Harpal S., Vinod Menon, James Brown, Hendrik Lehnert, Menon, Vinod, Raghu Adya, Manjunath Ramanjaneya, Harpal S. Randeva, Ramanjaneya, Manjunath, Chen, Jing, Lehnert, Hendrik   +17 more
core   +1 more source

Upadacitinib and filgotinib: the role of JAK1 selective inhibition in the treatment of rheumatoid arthritis

Drugs in Context, 2019
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by joint involvement, extra-articular manifestations, comorbidities, and increased mortality.
Martina Biggioggero, Andrea Becciolini, Chiara Crotti, Elena Agape, Ennio Giulio Favalli   +4 more
doaj   +1 more source

Supplementary Table 1 for Special editorial: When prescribing Janus kinase inhibitors for dermatologic conditions, be mindful of the Food and Drug Administration’s September 1,2021, data safety communication

, 2022
Supplementary Table 1 for Special editorial: When prescribing Janus kinase inhibitors for dermatologic conditions, be mindful of the Food and Drug Administration’s September 1,2021, data safety communication.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT
Rick, J (via Mendeley Data)
core   +1 more source

Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival [PDF]

, 2012
Recent evidence suggests CML stem cells are insensitive to kinase inhibitors and responsible for minimal residual disease in treated patients. We investigated whether CML stem cells, in a transgenic mouse model of CML-like disease or derived from ...
Allan, Elaine K., Mueller-Tidow, Carsten, Nicolini, Franck E., Bhatia, Ravi, Brunton, Valerie G, Myssina, Svetlana, Hamilton, Ashley, Mysina, Svetlana, Müller-Tidow, Carsten, Koschmieder, Steffen, Allan, Elaine K, Helgason, G. Vignir, Helgason, G Vignir, Brunton, Valerie G., Schemionek, Mirle, Zhang, Bin, Holyoake, Tessa L., Holyoake, Tessa L, Nicolini, Franck E   +18 more
core   +1 more source

The Future of Janus Kinase Inhibitors in Inflammatory Bowel Disease

, 2017
Inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, are disabling conditions characterised by chronic, relapsing inflammation of the gastrointestinal tract.
de Jonge, Wouter, Wildenberg, Manon, de Vries, Leonie, D'Haens, Geert   +3 more
core   +1 more source

Knockdown of long non-coding RNA HOXD-AS1 inhibits gastric cancer cell growth via inactivating the JAK2/STAT3 pathway

Tumor Biology, 2017
Long non-coding RNA HOXD-AS1 (HOXD cluster antisense RNA 1) has been demonstrated to be closely associated with the progression of several tumors. However, the biological function of HOXD-AS1 and the underlying molecular mechanism in gastric cancer are ...
Li Zheng, Jiangtao Chen, Zhongyong Zhou, Zhikuan He   +3 more
doaj   +1 more source

Jamip1 (Marlin-1) Defines a Family of Proteins Interacting with Janus Kinases and Microtubules [PDF]

Journal of Biological Chemistry, 2004
Jamip1 (Jak and microtubule interacting protein), an alias of Marlin-1, was identified for its ability to bind to the FERM (band 4.1 ezrin/radixin/moesin) homology domain of Tyk2, a member of the Janus kinase (Jak) family of non-receptor tyrosine kinases that are central elements of cytokine signaling cascades. Jamip1 belongs to a family of three genes
Corinna, Steindler, Zhi, Li, Michèle, Algarté, Andrès, Alcover, Valentina, Libri, Josiane, Ragimbeau, Sandra, Pellegrini   +6 more
openaire   +2 more sources

Treatment of alopecia areata with the Janus Kinase Inhibitor upadacitinib: a retrospective cohort study

, 2023
Supplementary Material for paper "Treatment of alopecia areata with the Janus Kinase Inhibitor upadacitinib: a retrospective cohort study" JAAD 2023THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
Frew, J (via Mendeley Data)
core   +1 more source