Results 21 to 30 of about 30,393,220 (286)

Itch and Janus Kinase Inhibitors [PDF]

, 2023
Itch is a common skin symptom, with complex aetiology and pathogenesis. It is mediated by 2 pathways, the histaminergic and non-histaminergic pathways.
Cho, Sang Hyun, Han, Yujin, Kim, Hei Sung, Woo, Yu Ri, Lee, Jeong Deuk   +4 more
core   +1 more source

Loss of Cardiomyocyte Janus Kinase 1 (Jak1) Causes Cardiomyopathy

Journal of Molecular and Cellular Cardiology Plus
Arasakumar Subramani, Kobina Essandoh, Michael Y. Young, Kay-Uwe Wagner, Matthew J. Brody   +4 more
doaj   +2 more sources

Peripheral neuropathy associated with tofacitinib use in alopecia universalis

Journal of Dermatology and Dermatologic Surgery, 2022
Alopecia areata (AA) is an autoimmune disease characterized by nonscarring hair loss. Alopecia universalis (AU) is the advanced form of AA characterized by complete scalp and body hair loss.
Raghad Alharthi, Fatimah Alowirdi, Saba Alsuhaymi, Mohammed AlQahtani, Afaf Alsheikh   +4 more
doaj   +1 more source

Pharmacology of inhibitors of Janus kinases – Part 1: Pharmacokinetics

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 2022
SummaryThe use of Janus kinase inhibitors for the treatment of chronic inflammatory diseases is increasingly establishing itself as a treatment option for several indications. In order to make clinical use efficient, pharmacological knowledge of the JAK/STAT signaling pathway and the special features of the pharmacokinetics of the individual drugs is ...
Adina, Eichner, Johannes, Wohlrab
openaire   +2 more sources

Janus kinase 1/2 inhibition with baricitinib in the treatment of juvenile dermatomyositis. [PDF]

Brain, 2019
Papadopoulou C, Hong Y, Omoyinmi E, Brogan PA, Eleftheriou D.   +4 more
europepmc   +5 more sources

Untangle a Broken Heart via Janus Kinase 1 [PDF]

Circulation Research, 2017
Protein homeostasis and quality control, as balanced by synthesis and degradation, is critical to cellular health and normal cardiac function. Similar to amyloid-related neurodegenerative diseases, the familial forms of amyloid cardiomyopathy are characterized by protein aggregate accumulation in cardiomyocytes.
Chen, Gao, Yibin, Wang
openaire   +2 more sources

Janus Kinase Inhibitors: Safety in Patients With Psoriatic Arthritis

, 2022
Janus kinase inhibitors (JAKi; or Jakinibs) have become widely prescribed around the world for a variety of immune-mediated inflammatory diseases, including psoriatic arthritis.
Nash, P
core   +1 more source

Janus Kinase Deregulation in Leukemia and Lymphoma [PDF]

, 2012
Genetic alterations affecting members of the Janus kinase (JAK) family have been discovered in a wide array of cancers and are particularly prominent in hematological malignancies.
Chen, Edwin, Staudt, L.M., Green, Anthony R., Staudt, Louis M., Chen, E., Green, A.R.   +5 more
core   +1 more source

Generation of Janus kinase 1 (JAK1) conditional knockout mice [PDF]

genesis, 2016
AbstractThe biological functions of the Janus kinase 1 (JAK1) are suggested to be pleiotropic since this signal transducer is ubiquitously expressed and coupled to a variety of cytokine receptors. Consequently, mice that are deficient in this tyrosine kinase were reported to die shortly after birth. To facilitate studies that address the biological and
Kazuhito, Sakamoto, Barbara L, Wehde, Patrick D, Rädler, Aleata A, Triplett, Kay-Uwe, Wagner   +4 more
openaire   +2 more sources

A comparison of Janus kinase inhibitor safety in rheumatoid arthritis

, 2021
The last decade has seen considerable advancement in the treatment options available to patients with rheumatoid arthritis (RA) through the development of oral, small molecules that target and inhibit Janus kinases (JAKi).
Marabani, Mona, Mona Marabani, Lim, Irwin, Irwin Lim, Peter Nash, Nash, Peter   +5 more
core   +1 more source