Results 1 to 10 of about 51,056 (164)
Successful Treatment of Severe Nail Lichen Planus with Janus Kinase 1 Inhibitor Abrocitinib
Clinical, Cosmetic and Investigational DermatologyYingzhi Luo,1,* Jian Wu,2,* Xingyun Zhao,1,* Ping Yang,1 Yunmi Qiu,1 Liming Wu,1 Jianbo Zhong1 1Department of Dermatology, Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University, Hangzhou, Zhejiang ...
Luo Y +6 more
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Immunological Medicine, 2023 Recent studies have gradually elucidated the pathogenesis of inflammatory bowel disease; thus, the Janus kinase (JAK)-signal transducers and activators of transcription pathway are strongly involved in the pathophysiology of inflammatory bowel disease ...
Hiroshi Nakase
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The use of Tofacitinib in the treatment of inflammatory bowel disease [PDF]
Терапевтический архив, 2019 Major advances in pharmacology of the 21st century include the development of a new class of drugs, which are low-molecular, chemically synthesized molecules (the so-called "small molecules"), the point of application of which is Janus kinase (Janus ...
E L Nasonov +2 more
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Janus kinase inhibitor audit [PDF]
Clin Med (Lond), 2023 Beck J, Banford S.
europepmc +2 more sources
Itch and Janus Kinase Inhibitors
Acta Dermato-Venereologica, 2023 Itch is a common skin symptom, with complex aetiology and pathogenesis. It is mediated by 2 pathways, the histaminergic and non-histaminergic pathways. Chronic itch is understood to be processed by the latter and is difficult to treat with traditional pruritus therapies. The Janus kinase and signal transducer and activator of transcription pathway is a
Yujin Han +4 more
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BMC Infectious Diseases, 2021 Background The spread of a highly pathogenic, novel coronavirus (SARS-CoV-2) has emerged as a once-in-a-century pandemic, having already infected over 63 million people worldwide. Novel therapies are urgently needed.
Lucas Walz +6 more
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Peripheral neuropathy associated with tofacitinib use in alopecia universalis
Journal of Dermatology and Dermatologic Surgery, 2022 Alopecia areata (AA) is an autoimmune disease characterized by nonscarring hair loss. Alopecia universalis (AU) is the advanced form of AA characterized by complete scalp and body hair loss.
Raghad Alharthi +4 more
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Janus Kinase Inhibitors and Cell Therapy [PDF]
Frontiers in Immunology, 2021 Cellular therapies such as allogeneic hematopoietic stem cell transplantation (HSCT) and immune-effector cell therapy (IECT) continue to have a critical role in the treatment of patients with high risk malignancies and hematologic conditions. These therapies are also associated with inflammatory conditions such as graft-versus-host disease (GVHD) and ...
Amer Assal +2 more
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Glucocorticoids combined with tofacitinib for systemic sarcoidosis with rash as initial symptom: a case report [PDF]
Xin yixue, 2023 Systemic sarcoidosis is a granulomatous disease involving multiple organs and systems. A 36-year-old woman was admitted due to multiple nodules of the trunk for 4 months. Upon admission， laboratory and auxiliary examinations were performed.
Hu Rongrong, Hong Yixin, Su Xiangyang, Ma Guiyan, Chen Peiran
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Journal of Cutaneous Immunology and Allergy, 2023 We present four Japanese patients with prurigo‐type AD who received upadacitinib. Rapid improvement of skin lesions and itchiness was seen in all patients. Janus kinase inhibitor is effective for prurigo‐type AD by strongly suppressing itching.
Keiji Kosaka +3 more
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