Results 51 to 60 of about 31,567 (277)

Protein kinases as therapeutic targets to develop anticancer drugs with natural alkaloids

Frontiers in Bioscience-Landmark, 2021
Backgroud: Protein kinases play an important role in cell proliferation, differentiation, mobility and cell cycle arrest etc. These enzymes act as important targets in developing anticancer agents.
Hanlin Ye, Linlin Wang, Li Ma, Maksim Ionov, Gan Qiao, Jianlin Huang, Li Cheng, Yuxi Zhang, Xiaohui Yang, Shousong Cao, Xiukun Lin   +10 more
doaj   +1 more source

Unraveling Vitiligo: From Immune Mechanisms to Promising Therapeutic Strategies [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy
Vitiligo is a dermatological condition affecting 1% of the global population, characterized by the loss of skin pigmentation. It appears in two main forms: nonsegmental (symmetrical depigmentation) and segmental (localized depigmentation).
Artur Kovenskiy, Nurlubek Katkenov, Zhussipbek Mukatayev, Almagul Kushugulova   +3 more
doaj   +1 more source

Defining the functional binding sites of interleukin 12 receptor β1 and interleukin 23 receptor to Janus kinases. [PDF]

Mol Biol Cell, 2016
The interleukin (IL)-12-type cytokines IL-12 and IL-23 are involved in T-helper (Th) 1 and Th17 immunity, respectively. They share the IL-12 receptor beta 1 (IL-12R beta 1) as one component of their receptor signaling complexes, with IL-12R beta 2 as ...
Floss DM, Klöcker T, Schröder J, Lamertz L, Mrotzek S, Strobl B, Hermanns H, Scheller J.   +7 more
europepmc   +3 more sources

Cooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F [PDF]

, 2013
peer reviewedThe Janus kinase 2 mutant V617F occurs with high frequency in myeloproliferative neoplasms. Further mutations affecting the Janus kinase family have been discovered mostly in leukaemias and in myeloproliferative neoplasms.
Eulenfeld, R., Palissot, V., BEHRMANN, Iris, Berchem, G., ROLVERING, Catherine, Méndez, S. A., Gäbler, Karoline, KACZOR, Jakub, HAAN, Claude   +8 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Janus Kinases in intestinal homeostasis [PDF]

, 2021
Morbus Crohn (CD) und Colitis ulcerosa (UC) sind zwei Formen von chronisch entzündlichen Darmerkrankungen (CED) beim Menschen. Neben genetischen Faktoren, spielen auch die endogene mikrobielle Flora, die Darmbarriere und eine inadäquate Immunantwort eine
Texler, Bernhard
core   +4 more sources

Potential applications of JAK inhibitors, clinically approved drugs against autoimmune diseases, in cancer therapy

Frontiers in Pharmacology
Disturbances in immunoregulation may lead to both cancer and autoimmune diseases. Many therapeutic drugs for autoimmune diseases also display anti-tumor efficacy.
Xiao-Huan Wei, Xiao-Huan Wei, Xiao-Huan Wei, Yuan-Yuan Liu, Yuan-Yuan Liu   +4 more
doaj   +1 more source

Emerging Treatment Options in Inflammatory Bowel Disease: Janus Kinases, Stem Cells, and More. [PDF]

, 2020
BACKGROUND Treatment of inflammatory bowel diseases (IBD) has tremendously improved during the last 20 years; however, a substantial fraction of patients does not respond to available therapies or lose response, and new strategies are needed ...
Misselwitz, Benjamin, Brand, Stephan, Juillerat, Pascal, Siegmund, Britta, Sulz, Michael Christian   +4 more
core   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Identification of the protein kinases Pyk3 and Phg2 as regulators of the STATc-mediated response to hyperosmolarity [PDF]

, 2014
Cellular adaptation to changes in environmental osmolarity is crucial for cell survival. In Dictyostelium, STATc is a key regulator of the transcriptional response to hyperosmotic stress. Its phosphorylation and consequent activation is controlled by two
Christoph S Clemen, Linh Hai Vu (527338), Clemen, Christoph S., Na, Jianbo, Christoph S. Clemen (130148), Araki, Tsuyoshi, Linh Hai Vu, Na Jianbo, Araki Tsuyoshi, Tsuyoshi Araki (506033), Williams Jeffrey G., Eichinger Ludwig, Vu Linh Hai, Eichinger, Ludwig, Jeffrey G Williams, Williams, Jeffrey G., Jianbo Na, Ludwig Eichinger, Tsuyoshi Araki, Jianbo Na (12352), Clemen Christoph S., Vu, Linh Hai, Jeffrey G. Williams (335697), Ludwig Eichinger (11966)   +23 more
core   +1 more source