Results 41 to 50 of about 436,066 (210)

Myocardial performance index to assess cardiac function in spondyloarthritis: A systematic review and meta-analysis

Romanian Journal of Internal Medicine
This study aimed to assess cardiac function using the Myocardial Performance Index (MPI) in spondyloarthritis (SpA) patients.
Alvianto Steven, Parlindungan Faisal, Dalimunthe Naomi Niari, Widjanarko Nicolas Daniel, Gotama Yovita, Kultsum Ummi, Efendi Cristopher   +6 more
doaj   +1 more source

JAK Inhibitors as Potential Therapeutic Strategy for the Dilemma of Psoriasis Concurrent with Dermatomyositis in the SARS-CoV-2 Era

Clinical, Cosmetic and Investigational Dermatology, 2023
Qiannan Xu, Nan Xu Department of Dermatology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Nan Xu, Tel +86 38804518, Email xnhrb@sina.comAbstract: Dermatomyositis is a rare inflammatory
Xu Q, Xu N
doaj  

Effect of Abrocitinib on the Skin Microbiome in Patients With Moderate‐to‐Severe Atopic Dermatitis

Allergy, Volume 81, Issue 10, Page 3599-3607, October 2026.
Atopic dermatitis (AD) is characterized by microbial dysbiosis. This study aimed to evaluate the effects of abrocitinib, a JAK1‐selective inhibitor, on the skin microbiome and its potential associations with clinical outcomes in patients with AD. Abrocitinib treatment was associated with increased skin microbial diversity and decreased Staphylococcus ...
Madeline Kim, Ester Del Duca, Joel Correa Da Rosa, Juliana Pulsinelli, Yeriel Estrada, Dan Xu, Gary Chan, Allshine Chen, Erman Güler, Karen Page, Emma Guttman‐Yassky   +10 more
wiley   +1 more source

Interleukin‐6 role in head and neck squamous cell carcinoma progression

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 2, Issue 2, Page 90-97, June 2016., 2016
Abstract Interleukin‐6 (IL‐6) is a pleiotropic cytokine which plays an important role in a number of cellular processes including proliferation, survival, differentiation, migration and invasion. IL‐6 mediates its downstream effects by activating a number of signaling cascades including JAK/STAT, PI3K/AKT and MAPK pathways.
Moaz M. Choudhary, Thomas J. France, Theodoros N. Teknos, Pawan Kumar   +3 more
wiley   +1 more source

Student w centrum – jak projektować zajęcia?

, 2022
Z nagrania dowiesz się: czym jest kształcenie zorientowane na studenta (ang. student-centered design), jakie są założenia, korzyści, warunki brzegowe oraz wyzwania wynikające z tego sposobu projektowania, jak szybko włączyć to podejście do własnej ...
Hmiedat, Paula, Grodecka, Karolina
core  

Translating JAKs to Jakinibs [PDF]

The Journal of Immunology, 2020
Abstract The discovery of JAKs and STATs and their roles in cytokine and IFN action represented a significant basic advance and a new paradigm in cell signaling. This was quickly followed by discoveries pointing to their essential functions, including identification of JAK3 mutations as a cause of SCID.
Massimo Gadina, Danielle A Chisolm, Rachael L Philips, Iain B McInness, Paul S Changelian, John J O’Shea   +5 more
openaire   +2 more sources

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang, Pengzhan He, Cheng Liu, Xin Chen, Yilin Tan, Rui Qu, Yan Zhang, Zhou Li, Tailang Yin, Zhinang Yin   +9 more
wiley   +1 more source

Inhibition of the JAK2/STAT3 Pathway Attenuates D‐Galactose‐Induced Nucleus Pulposus Cell Senescence and Intervertebral Disc Degeneration

Stem Cells International, Volume 2025, Issue 1, 2025.
Objective This study aimed to investigate the effect of Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway inhibition on D‐galactose (D‐gal)‐induced senescence in nucleus pulposus cells (NPCs) and its potential to delay intervertebral disc degeneration (IVDD), as well as to investigate the underlying mechanisms ...
Weidong Liang, Shuwen Zhang, Xiaoyu Cai, Yao Wang, Honggang Hao, Kup Ya, Jun Sheng, Weibin Sheng, Yuelin Zhang   +8 more
wiley   +1 more source

JAK inhibitor: Introduction

Indian Journal of Dermatology, Venereology and Leprology, 2023
The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway is a key regulatory signaling system for cellular proliferation, differentiation, and apoptosis. In addition, JAK signaling pathway plays critical roles in orchestrating immune response through its interactions with the cytokine receptors and the transcriptions ...
Siba P, Raychaudhuri, Smriti K, Raychaudhuri   +1 more
openaire   +2 more sources

The language of symbols in prehistoric Anatolia

Documenta Praehistorica, 2005
The conceptual and ritual background of symbolism in the prehistoric art of Anatolia should be investigated within the socio-economic background of the pertinent Neolithic and Chalcolithic societies.
Jak Yakar
doaj   +1 more source