Results 41 to 50 of about 852,629 (213)

The Janus kinases (Jaks) [PDF]

Genome Biology, 2004
The Janus kinase (Jak) family is one of ten recognized families of non-receptor tyrosine kinases. Mammals have four members of this family, Jak1, Jak2, Jak3 and Tyrosine kinase 2 (Tyk2). Birds, fish and insects also have Jaks. Each protein has a kinase domain and a catalytically inactive pseudo-kinase domain, and they each bind cytokine receptors ...
Yamaoka, Kunihiro, Saharinen, Pipsa, Pesu, Marko, Holt, Vance ET, Silvennoinen, Olli, O'Shea, John J   +5 more
openaire   +3 more sources

JAK Inhibitors as Potential Therapeutic Strategy for the Dilemma of Psoriasis Concurrent with Dermatomyositis in the SARS-CoV-2 Era

Clinical, Cosmetic and Investigational Dermatology, 2023
Qiannan Xu, Nan Xu Department of Dermatology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Nan Xu, Tel +86 38804518, Email xnhrb@sina.comAbstract: Dermatomyositis is a rare inflammatory
Xu Q, Xu N
doaj  

Myocardial performance index to assess cardiac function in spondyloarthritis: A systematic review and meta-analysis

Romanian Journal of Internal Medicine
This study aimed to assess cardiac function using the Myocardial Performance Index (MPI) in spondyloarthritis (SpA) patients.
Alvianto Steven, Parlindungan Faisal, Dalimunthe Naomi Niari, Widjanarko Nicolas Daniel, Gotama Yovita, Kultsum Ummi, Efendi Cristopher   +6 more
doaj   +1 more source

Hotspoty w bibliotekach – jak bardzo powszechne, jak bardzo potrzebne? [PDF]

, 2018
A period, in which getting the access to the Internet at the library required using the computer belonging to the library, and most often wired connected to the network, is ending.
Grygrowski, Dariusz
core   +1 more source

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang, Pengzhan He, Cheng Liu, Xin Chen, Yilin Tan, Rui Qu, Yan Zhang, Zhou Li, Tailang Yin, Zhinang Yin   +9 more
wiley   +1 more source

JAK inhibitors in autoinflammation [PDF]

Journal of Clinical Investigation, 2018
Interferonopathies are a subset of autoinflammatory disorders with a prominent type I IFN gene signature. Treatment of these patients has been challenging, given the lack of response to common autoinflammatory therapeutics including IL-1 and TNF blockade.
Hal M, Hoffman, Lori, Broderick
openaire   +2 more sources

Agora Meyhanesi ve ötesi [PDF]

, 1991
Taha Toros Arşivi, Dosya No: 112-Meyhanelerİstanbul Kalkınma Ajansı (TR10/14/YEN/0033) İstanbul Development Agency (TR10/14/YEN ...
Deleon, Jak
core  

Inhibition of the JAK2/STAT3 Pathway Attenuates D‐Galactose‐Induced Nucleus Pulposus Cell Senescence and Intervertebral Disc Degeneration

Stem Cells International, Volume 2025, Issue 1, 2025.
Objective This study aimed to investigate the effect of Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway inhibition on D‐galactose (D‐gal)‐induced senescence in nucleus pulposus cells (NPCs) and its potential to delay intervertebral disc degeneration (IVDD), as well as to investigate the underlying mechanisms ...
Weidong Liang, Shuwen Zhang, Xiaoyu Cai, Yao Wang, Honggang Hao, Kup Ya, Jun Sheng, Weibin Sheng, Yuelin Zhang   +8 more
wiley   +1 more source

Pera Palas'ın gerçek gerçekleri [PDF]

, 1991
Taha Toros Arşivi, Dosya No: 115-Otellerİstanbul Kalkınma Ajansı (TR10/14/YEN/0033) İstanbul Development Agency (TR10/14/YEN ...
Deleon, Jak
core  

The excavation of Non Ban Jak, Northeast Thailand - A report on the first three seasons [PDF]

, 2014
Non Ban Jak is a large, moated site located in the upper Mun Valley, Northeast Thailand. Excavations over three seasons in 2011-4 have revealed a sequence of occupation that covers the final stage of the local Iron Age.
Cameron, Judith, Castillo, Cristina, Chang, Nigel, Halcrow, Sian, Higham, Charles, O'Reilly, Dougald, Petchey, Fiona, Shewan, Louise   +7 more
core   +3 more sources