Results 51 to 60 of about 436,478 (164)

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang, Pengzhan He, Cheng Liu, Xin Chen, Yilin Tan, Rui Qu, Yan Zhang, Zhou Li, Tailang Yin, Zhinang Yin   +9 more
wiley   +1 more source

Inhibition of the JAK2/STAT3 Pathway Attenuates D‐Galactose‐Induced Nucleus Pulposus Cell Senescence and Intervertebral Disc Degeneration

Stem Cells International, Volume 2025, Issue 1, 2025.
Objective This study aimed to investigate the effect of Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway inhibition on D‐galactose (D‐gal)‐induced senescence in nucleus pulposus cells (NPCs) and its potential to delay intervertebral disc degeneration (IVDD), as well as to investigate the underlying mechanisms ...
Weidong Liang, Shuwen Zhang, Xiaoyu Cai, Yao Wang, Honggang Hao, Kup Ya, Jun Sheng, Weibin Sheng, Yuelin Zhang   +8 more
wiley   +1 more source

The language of symbols in prehistoric Anatolia

Documenta Praehistorica, 2005
The conceptual and ritual background of symbolism in the prehistoric art of Anatolia should be investigated within the socio-economic background of the pertinent Neolithic and Chalcolithic societies.
Jak Yakar
doaj   +1 more source

JAK inhibitors ∼ overview∼

Immunological Medicine, 2023
Among various tyrosine kinases, a family of Janus kinases (JAK) has been elucidated as key players in signal transduction from vital cytokine receptors, such as interleukins and interferons.
Hideto Kameda
doaj   +1 more source

Clinical use of Jak 1 inhibitors for rheumatoid arthritis

, 2021
The uptake of Jak inhibitors in the RA space has been among the most rapid in rheumatology, based on the results of comprehensive clinical trial programmes of five agents.
Nash, Peter
core   +1 more source

THE RESPONSIBILITY OF THE STATE FOR FINANCIAL MARKETS

Ekonomia i Prawo, 2009
The aim of this paper is to compare various models of state responsibility for access to financial markets. The results of this comparison was used to limit the public intervention during the global financial crisis.
Jak K. Solarz
doaj   +1 more source

Insight into Janus kinases specificity: From molecular architecture to cancer therapeutics

MedComm – Oncology, Volume 3, Issue 1, March 2024.
Despite their significant efficacy in cancer therapy, current Janus kinases inhibitors (JAKi) are limited for their selectivity, which can cause off‐target effects. This remains a major clinical challenge. This review aims to integrates three‐dimensional structural information with comprehensive pharmacological data to study the determinants of ...
Tian‐Hua Wei, Meng‐Yi Lu, Si‐Hui Yao, Yu‐Qi Hong, Jin Yang, Meng‐Yuan Zhang, Yu‐Qi Yin, Yu‐Jie Han, Qing‐Qing Li, Zi‐Xuan Wang, Yi‐Bo Wang, Zhen‐Jiang Tong, Yun Zhou, Wei‐Chen Dai, Yan‐Cheng Yu, Shan‐Liang Sun, Ye Yang, Nian‐Guang Li, Zhi‐Hao Shi   +18 more
wiley   +1 more source

Myocardial Performance Index to assess cardiac function in autoimmune connective tissue disease: a systematic review and meta-analysis

Lupus Science and Medicine
Objectives This study aimed to evaluate cardiac function using Myocardial Performance Index (MPI) in autoimmune connective tissue disease (ACTD) patients without cardiovascular abnormalities.Methods A systematic search of databases including Medline ...
Rudy Hidayat, Sally Aman Nasution, Faisal Parlindungan, Naomi Niari Dalimunthe, Steven Alvianto, Nicolas Daniel Widjanarko, Ummi Kultsum, Cristopher Efendi, Yovita Gotama   +8 more
doaj   +1 more source

Relating Measurement Invariance, Cross-Level Invariance, and Multilevel Reliability

Frontiers in Psychology, 2017
Data often have a nested, multilevel structure, for example when data are collected from children in classrooms. This kind of data complicate the evaluation of reliability and measurement invariance, because several properties can be evaluated at both ...
Suzanne Jak, Terrence D. Jorgensen
doaj   +1 more source

Jak „widzą” niewidomi?

Perspektywy Kultury, 2022
Artykuł porusza problematykę nowej widzialności i reprodukcji pola społecznego „widzenia” u osób niewidomych jako „podmiotów wizualnych” w perspektywie studiów kultury wizualnej.
Konrad Chmielecki
doaj   +1 more source