Results 31 to 40 of about 852,629 (213)

Inhibitors of CK2 Kinase for the Treatment of Gliomas and Other Brain Tumors [PDF]

Acta Poloniae Pharmaceutica
Protein kinase CK2 has become a target of experimental antiglioma therapies as laboratory data are almost uniformly favorable and the number of synthetized CK2 inhibitors is rapidly growing.
Emanuela B. Pucko, Robert P. Ostrowski
doaj   +1 more source

Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma

Drug Design, Development and Therapy, 2022
Magnus Nilsson,1 Magdalena Rhedin,2 Ramon Hendrickx,3 Susanne Berglund,1 Antonio Piras,2 Parmis Blomgran,2 Anders Cavallin,2 Mia Collins,2 Göran Dahl,4 Bilel Dekkak,5 Therese Ericsson,3 Niklas Hagberg,6 Ann Aurell Holmberg,3 Agnes Leffler,2 Anders J ...
Nilsson M, Rhedin M, Hendrickx R, Berglund S, Piras A, Blomgran P, Cavallin A, Collins M, Dahl G, Dekkak B, Ericsson T, Hagberg N, Holmberg AA, Leffler A, Lundqvist AJ, Markou T, Pinkerton J, Rönnblom L, Siu S, Taylor V, Wennberg T, Zervas D, Laurence ADJ, Mitra S, Belvisi MG, Birrell M, Borde A   +26 more
doaj  

Effects of CaO, Al2O3 and MgO on liquidus temperatures of copper smelting and converting slags under controlled oxygen partial pressures [PDF]

Journal of Mining and Metallurgy. Section B: Metallurgy, 2013
Phase equilibria of silicate slags relevant to the copper smelting/converting operations have been experimentally studied over a wide range of slag compositions, temperatures and atmospheric conditions.
Zhao B., Hayes P., Jak E.
doaj   +1 more source

Evaluating Cluster-Level Factor Models with lavaan and Mplus

Psych, 2021
Background: Researchers frequently use the responses of individuals in clusters to measure cluster-level constructs. Examples are the use of student evaluations to measure teaching quality, or the use of employee ratings of organizational climate.
Suzanne Jak, Terrence D. Jorgensen, Yves Rosseel   +2 more
doaj   +1 more source

Macrophage-derived upd3 Cytokine causes impaired glucose homeostasis and reduced lifespan in drosophila fed a lipid-rich diet [PDF]

, 2014
Long-term consumption of fatty foods is associated with obesity, macrophage activation and inflammation, metabolic imbalance, and a reduced lifespan. We took advantage of Drosophila genetics to investigate the role of macrophages and the pathway(s) that ...
Dionne, MS, Geissmann, F, Kierdorf, K, Pouchelon, CA, Vivancos, V, Woodcock, KJ   +5 more
core   +1 more source

Inhibition of IL‐6‐JAK/Stat3 signaling in castration‐resistant prostate cancer cells enhances the NK cell‐mediated cytotoxicity via alteration of PD‐L1/NKG2D ligand levels

Molecular Oncology, Volume 12, Issue 3, Page 269-286, March 2018., 2018
IL‐6 signaling, through downstream JAK/Stat3 signaling, plays a significant role in rendering castration‐resistant prostate cancer (CRPC) cells resistant to NK cell cytotoxicity by lowering the programmed death receptor ligand 1 level while increasing the NK group 2D ligand levels.
LiJun Xu, XiaoDong Chen, MingJing Shen, Dong‐Rong Yang, Laifu Fang, Guobin Weng, Ying Tsai, Peter C. Keng, Yuhchyau Chen, Soo Ok Lee   +9 more
wiley   +1 more source

Research progress on tofacitinib in the treatment of chronic actinic dermatitis

Pifu-xingbing zhenliaoxue zazhi
Chronic actinic dermatitis (CAD) is a group of immune-mediated diseases characterized by photosensitivity. Tofacitinib, a Janus kinase (JAK) 1/3 inhibitor, is currently the most extensively reported and widely used JAK inhibitor for the treatment of CAD.
WU Hui, SHEN Haojia, HE Zezhi, CHEN Jiaoquan, LI Runxiang, ZHU Huilan   +5 more
doaj   +1 more source

Detecting Transient Trapping from a Single Trajectory: A Structural Approach

Entropy, 2021
In this article, we introduce a new method to detect transient trapping events within a single particle trajectory, thus allowing the explicit accounting of changes in the particle’s dynamics over time.
Yann Lanoiselée, Jak Grimes, Zsombor Koszegi, Davide Calebiro   +3 more
doaj   +1 more source

Application of activity - based costing in companies in Poland [PDF]

, 2010
Findings of the research have both practical and theoretical implications. First, from the practical point of view, future implementers of ABC systems should be aware of factors actually influencing ABC implementation as well as problems which can be ...
Wnuk-Pel, Tomasz
core   +2 more sources

Interleukin‐6 role in head and neck squamous cell carcinoma progression

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 2, Issue 2, Page 90-97, June 2016., 2016
Abstract Interleukin‐6 (IL‐6) is a pleiotropic cytokine which plays an important role in a number of cellular processes including proliferation, survival, differentiation, migration and invasion. IL‐6 mediates its downstream effects by activating a number of signaling cascades including JAK/STAT, PI3K/AKT and MAPK pathways.
Moaz M. Choudhary, Thomas J. France, Theodoros N. Teknos, Pawan Kumar   +3 more
wiley   +1 more source