Results 31 to 40 of about 436,066 (210)

Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling [PDF]

, 2010
Chikungunya virus (CHIKV) is an emerging human pathogen transmitted by mosquitoes. Like that of other alphaviruses, CHIKV replication causes general host shutoff, leading to severe cytopathicity in mammalian cells, and inhibits the ability of infected ...
Ligtenberg, M., Suhrbier, A., Corinne Geertsema, Esther Schnettler, Fros, J., Just M. Vlak, Maarten Ligtenberg, Geertsema, C., Suhrbier, Andreas, Wen Jun Liu, Natalie A. Prow, Vlak, J.M., Dana L. Vanlandingham, Ligtenberg, Maarten, Khromykh, Alexander A., Jelke J. Fros, Vanlandingham, D.L., Vlak, Just M., Schnettler, E., Fros, J.J., Gorben P. Pijlman, Pijlman, G.P., Liu, W.J., Khromykh, A.A., Prow, A., Fros, Jelke J., Vanlandingham, Dana L., Liu, Wen Jun, Geertsema, Corinne, Prow, Natalie A., Alexander A. Khromykh, Schnettler, Esther, Pijlman, Gorben P., Andreas Suhrbier, Prow, N.A.   +34 more
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Inhibitors of CK2 Kinase for the Treatment of Gliomas and Other Brain Tumors [PDF]

Acta Poloniae Pharmaceutica
Protein kinase CK2 has become a target of experimental antiglioma therapies as laboratory data are almost uniformly favorable and the number of synthetized CK2 inhibitors is rapidly growing.
Emanuela B. Pucko, Robert P. Ostrowski
doaj   +1 more source

Evaluating Cluster-Level Factor Models with lavaan and Mplus

Psych, 2021
Background: Researchers frequently use the responses of individuals in clusters to measure cluster-level constructs. Examples are the use of student evaluations to measure teaching quality, or the use of employee ratings of organizational climate.
Suzanne Jak, Terrence D. Jorgensen, Yves Rosseel   +2 more
doaj   +1 more source

JAK-STAT and bone metabolism

, 2013
Emerging evidences suggest Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway plays an important role in bone development and metabolism.
Li, Jiliang
core   +1 more source

Research progress on tofacitinib in the treatment of chronic actinic dermatitis

Pifu-xingbing zhenliaoxue zazhi
Chronic actinic dermatitis (CAD) is a group of immune-mediated diseases characterized by photosensitivity. Tofacitinib, a Janus kinase (JAK) 1/3 inhibitor, is currently the most extensively reported and widely used JAK inhibitor for the treatment of CAD.
WU Hui, SHEN Haojia, HE Zezhi, CHEN Jiaoquan, LI Runxiang, ZHU Huilan   +5 more
doaj   +1 more source

Effects of CaO, Al2O3 and MgO on liquidus temperatures of copper smelting and converting slags under controlled oxygen partial pressures [PDF]

Journal of Mining and Metallurgy. Section B: Metallurgy, 2013
Phase equilibria of silicate slags relevant to the copper smelting/converting operations have been experimentally studied over a wide range of slag compositions, temperatures and atmospheric conditions.
Zhao B., Hayes P., Jak E.
doaj   +1 more source

Jak się robi Edutech w AGH?

, 2022
Dowiesz się dzięki Ewelinie Zalot, jak możesz wykorzystać aplikację GeoGebra, Apowersoft oraz LearningApps to narzędzia, które pokaże Aleksandra Wilk, jak nagrywać i montować filmiki edukacyjne w DaVinciResolve nauczy nas Karolina Kaczmarska ...
Kaczmarska, Karolina, Wilk, Aleksandra, Zalot, Ewelina   +2 more
core  

The Janus kinases (Jaks) [PDF]

Genome Biology, 2004
The Janus kinase (Jak) family is one of ten recognized families of non-receptor tyrosine kinases. Mammals have four members of this family, Jak1, Jak2, Jak3 and Tyrosine kinase 2 (Tyk2). Birds, fish and insects also have Jaks. Each protein has a kinase domain and a catalytically inactive pseudo-kinase domain, and they each bind cytokine receptors ...
Yamaoka, Kunihiro, Saharinen, Pipsa, Pesu, Marko, Holt, Vance ET, Silvennoinen, Olli, O'Shea, John J   +5 more
openaire   +3 more sources

Detecting Transient Trapping from a Single Trajectory: A Structural Approach

Entropy, 2021
In this article, we introduce a new method to detect transient trapping events within a single particle trajectory, thus allowing the explicit accounting of changes in the particle’s dynamics over time.
Yann Lanoiselée, Jak Grimes, Zsombor Koszegi, Davide Calebiro   +3 more
doaj   +1 more source

Inhibition of IL‐6‐JAK/Stat3 signaling in castration‐resistant prostate cancer cells enhances the NK cell‐mediated cytotoxicity via alteration of PD‐L1/NKG2D ligand levels

Molecular Oncology, Volume 12, Issue 3, Page 269-286, March 2018., 2018
IL‐6 signaling, through downstream JAK/Stat3 signaling, plays a significant role in rendering castration‐resistant prostate cancer (CRPC) cells resistant to NK cell cytotoxicity by lowering the programmed death receptor ligand 1 level while increasing the NK group 2D ligand levels.
LiJun Xu, XiaoDong Chen, MingJing Shen, Dong‐Rong Yang, Laifu Fang, Guobin Weng, Ying Tsai, Peter C. Keng, Yuhchyau Chen, Soo Ok Lee   +9 more
wiley   +1 more source