Results 251 to 260 of about 1,320,130 (285)

Ice-related flooding in the lower Yellow River driven by atmospheric teleconnections over the past 160 years. [PDF]

Sci Adv
Yu SY, Zhou L, Li W, Li C, Yu X, Franke J.   +5 more
europepmc   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Recurrent ileocolic variceal hemorrhage treated with superselective Onyx embolization: A case report. [PDF]

Radiol Case Rep
Babaei MR, Vaezi F, Rasuli B.
europepmc   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Interaction of brain endothelial cells with T cells: implications for progression and therapeutic strategies of multiple sclerosis. [PDF]

Front Neurol
Zhao Y, Zhu D.
europepmc   +1 more source

Evidence of Iron Accumulation in Cerebral Adrenoleukodystrophy: A Potential Novel Disease Mechanism

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT In this first application of Quantitative Susceptibility Mapping Source Separation to cerebral adrenoleukodystrophy, we uncovered alterations in iron and myelin within lesions and normal appearing white matter. As validation, we demonstrate abnormal iron accumulation in those same compartments within primary brain tissue.
Christina L. Nemeth, Mert Sisman, Jinwei Zhang, Hyeong‐geol Shin, Xu Li, Bela Turk, Ali Fatemi, Thanh Nguyen, Eric Mallack   +8 more
wiley   +1 more source

Lack of junctional adhesion molecule (JAM)-B traps CD8 T cells in CNS border zones and ameliorates autoimmune neuroinflammation. [PDF]

Acta Neuropathol Commun
Pareja J, Aydin S, Zbinden M, Bouillet E, Zollinger N, Theivendram V, Fahmi A, Pleskač P, Barcos S, Paas F, Kloster F, Blázquez AM, Fonta N, Merkler D, Deutsch U, Engelhardt B.   +15 more
europepmc   +1 more source

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source

The distinct biological role of JAML positions it as a promising target for treating human cancers and a range of other diseases. [PDF]

Front Immunol
Dong Z, Liu N, Sun M.
europepmc   +1 more source

JAM-C prevents ocular fibrosis by suppressing the TAZ/KLF6 pathway. [PDF]

J Adv Res
Chen M, Li W, Du Y, Zhao Y, Guo Y, Li Y, Wang X, Huang L, Zeng X, Zhang Y, Huang G, Wang S, Kuang H, Sun G, Jiang Q, Li X, Lu W.   +16 more
europepmc   +1 more source