Results 131 to 140 of about 114,094,772 (295)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
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, 2010 Jam pot, turquoise with black spots. with hinged lid and handle to one side. Transparent inner container. Date: 1959 - from the The Betty Smithers Design Collection at Staffordshire University.
The Betty Smithers Design Collection at Staffordshire University +1 more
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
HYDRAULIC MODEL EXPERIMENTS ON ICE JAM OCCURRENCE CONSIDERING THE EFFECTS OF BRANCH RIVER JUNCTION [PDF]
, 2017 本研究は結氷河川におけるアイスジャム発生と河道形状の関係を明らかにすることを目的としている．水理模型実験を用いた既往研究では，河氷の速度，幅，厚さ，長さ，川幅の拡縮割合を用いてアイスジャムの規模を表し，アイスジャムによる河氷の速度の減衰割合を評価している．しかしながら，既往研究では支川合流の影響を考慮していない．本研究では支川合流を考慮した水理模型実験を行ない，アイスジャムの規模を表す値の適用性について検討した．さらに平面2次元不等流計算で算出したアイスジャムの規模を表す値から河氷速度の減衰割合を推定し，
岡部, 博一 +5 more
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72th Annual Meeting of the APS Division of Fluid Dynamics - Gallery of Fluid Motion, 2019 Srishti Arora, Michelle Driscoll
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
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Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
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Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
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, 2009 Summary\ud \ud AV-Jam is an application that generates music and video that you can control while it plays.\ud \ud It is collaborative interactive artwork, enabling its subjects to jointly control the music and video using a network of control surfaces ...
Brown, Andrew R., Dillon, Steven C.
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Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source