Results 101 to 110 of about 1,087,544 (300)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
$L^p$ improving bounds for averages along curves [PDF]
, 2002 We establish local $(L^p,L^q)$ mapping properties for averages on curves. The exponents are sharp except for endpoints.Comment: 37 pages, simplified argument (no further need for algebraic complexity theory!), to appear ...
Tao, Terence, Wright, Jim
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2022 Background and Aim Given the increasing number of patients with multiple sclerosis and the psychological complications that affect this group, the present study was conducted to compare the effectiveness of acceptance and commitment therapy and ...
Pardis MirMoeini +2 more
doaj
Assessing the aridity indices in Northeast Iran: Implications for climate change and agricultural water management. [PDF]
DesertAridity indices have been widely applied in dividing climate regimes and monitoring drought events. The knowledge of the aridity index and reference evapotranspiration is very important not only for understanding climate change and its effects on ...
Z. Shirmohammadi Aliakbarkhani +4 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Research on Addiction, 2015 Objective: The present study was an attempt to examine the effectiveness of mindfulness-based group cognitive therapy in reducing depression and obsessive rumination among women under methadone treatment.
S taimory, F ramezani, N mahjob
doaj