Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Expression of junctional adhesion molecule-C (JAM-C) in human arthritic synovium [PDF]
, 2011 Copyright information:Taken from "Expression and function of junctional adhesion molecule-C in human and experimental arthritis"http://arthritis-research.com/content/9/4/R65Arthritis Research & Therapy 2007;9(4):R65-R65.Published online 5 Jul 2007PMCID ...
Gaby Palmer (636) +8 more
core +1 more source
Evaluation of Yield and Some Root and Morphological Characteristics Response of Guar (Cyamopsis tetragonoloba L.) in Intercropping with Roselle (Hibiscus sabdariffa L.) under Nitrogen Fertilizer Management [PDF]
بوم شناسی کشاورزیIntroductionGuar (Cyamopsis tetragonoloba L.) is an annual plant that tolerates salinity and drought from the legume family, which can be used as an alternative product in low-water plains. Considering the characteristics of the guar, such as having the
Mohammadnaser Modoodi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Treatment with anti-JAM-C antibody decreases neutrophil infiltration into the joints during antigen-induced arthritis [PDF]
, 2011 Copyright information:Taken from "Expression and function of junctional adhesion molecule-C in human and experimental arthritis"http://arthritis-research.com/content/9/4/R65Arthritis Research & Therapy 2007;9(4):R65-R65.Published online 5 Jul 2007PMCID ...
Gaby Palmer (636) +8 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
JAM-C is turned over dynamically at the endothelial junction, and the rate of internalisation is increased during junctional disassembly and inflammation. [PDF]
, 2019 (A) HUVECs were fed with JAM-C antibody, excess antibody was removed, and the cells were incubated at 37°C before being fixed at 0 and 2 h and imaged by confocal microscopy. Scale bar, 20 μm; boxed regions are shown at higher magnification.
Vinothini Rajeeve (4257748) +9 more
core +1 more source
From Jam to Start-up:A framework to support entrepreneurship at game jams and production oriented workshops [PDF]
, 2015 Production workshops such as game jams are popular waysof letting participants acquire hands-on knowledge and experiencein producing an artifact or game prototype in avery limited timespan.
Reng, Lars +3 more
core +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
HYDRAULIC MODEL EXPERIMENTS ON ICE JAM OCCURRENCE CONSIDERING THE EFFECTS OF BRANCH RIVER JUNCTION [PDF]
, 2017 本研究は結氷河川におけるアイスジャム発生と河道形状の関係を明らかにすることを目的としている．水理模型実験を用いた既往研究では，河氷の速度，幅，厚さ，長さ，川幅の拡縮割合を用いてアイスジャムの規模を表し，アイスジャムによる河氷の速度の減衰割合を評価している．しかしながら，既往研究では支川合流の影響を考慮していない．本研究では支川合流を考慮した水理模型実験を行ない，アイスジャムの規模を表す値の適用性について検討した．さらに平面2次元不等流計算で算出したアイスジャムの規模を表す値から河氷速度の減衰割合を推定し，
岡部, 博一 +5 more
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