Results 81 to 90 of about 1,087,544 (300)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Ground-Water Quality in Islamkot and Mithi Talukas of District Tharparkar, Sindh, Pakistan
Mehran University Research Journal of Engineering and Technology, 2019 Surface water supplies are gradually becoming short in arid and semi-arid regions of the world. Thus, assessment of groundwater quality for crop use appears to be very essential for management and utilization of precious natural water resources.
Jhaman Das Suthar +4 more
doaj +1 more source
How many independent bets are there?
, 2008 The benefits of portfolio diversification is a central tenet implicit to modern financial theory and practice. Linked to diversification is the notion of breadth.
AM Rudin +10 more
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Comparison of computer-based cognitive stimulation efficacy with and without transcranial direct current stimulation (tDCS) on the quality of life of patients recovered from Covid-19 [PDF]
مجله علوم روانشناختیBackground: Post-COVID-19 neurological sequelae may have a long-term negative impact on cognitive functions and quality of life in recovered patients.
Alireza Lotfi +2 more
doaj
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
A New Universality for Random Sequential Deposition of Needles
, 2000 Percolation and jamming phenomena are investigated for random sequential deposition of rectangular needles on $d=2$ square lattices. Associated thresholds $p_c^{perc}$ and $p_c^{jam}$ are determined for various needle sizes.
Galam, S., Kramer, M., Vandewalle, N.
core +2 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Radiation-Induced Graft Copolymerization of Methyl Acrylate and Acrylic Acid onto Rubber Wood Fiber [PDF]
, 2002 Graft copolymerization of methyl acrylate and acrylic acid monomers onto rubber wood fiber (RWF) was carried out by simultaneous radiation-induced technique.
Jam, Saliza
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source