Results 91 to 100 of about 1,015 (255)

DeepLNM: A Multimodal Model for Predicting Lymph Node Metastasis in Colorectal Cancer

Advanced Science, EarlyView.
Traditional diagnosis may miss positive LNM cases, and pathologists face a workload; therefore, we develop DeepLNM, a multimodal model that predicts lymph node metastasis in colorectal cancer from H&E WSIs, CT images, and text. DeepLNM is robust across internal, external, and prospective cohorts and, in a user study, improves diagnostic accuracy while ...
Zhengyu Zhang, Chengyu Lu, Zhen Wang, Zhijian Cen, Yangshu Zhou, Danyi Li, Qi Xie, Bingbing Li, Shujing Guo, Zhijun Gan, Er‐ran Zhu, Jinbang Li, Aihetaimu Aimaier, Rui Mao, Weihao Qiu, Chenglong Zhao, Ying Tan, Xiaolin Liu, Huiting Ma, Tiansu Geng, Peiyue Wu, Huijun Du, Yu Wang, Yueping Liu, Li Liang   +24 more
wiley   +1 more source

Bio‐Memristor Based on Clinical Bile Samples: A Proof‐of‐Concept Pilot Study for Detection of Gallbladder Cancer

Advanced Science, EarlyView.
In this work, we present a bile‐based memristor hardware framework that enables direct, label‐free identification of cholelithiasis and gallbladder cancer at the device level. The Ag/bile/FTO memristor features stable resistive switching and disease‐specific electrical responses, providing a conceptual foundation for circuits and an integrated ERCP ...
Junming Zhu, Yiyin Rong, Bai Sun, Ziwen Sun, Yifan Wang, Xiaobin Ren, Zelin Cao, Kaikai Gao, Jiawei Yu, Zhenkun Wang, Haoxuan Ma, Jichun Guo, Kai Cao, Mengrun Kang, Songling Wang, Fenggang Ren, Yi Lv, Qiang Lu   +17 more
wiley   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Quantifying the Dynamics of Network Detachment Across Scientific, Technological, Commercial, and Pharmacological Domains

Advanced Science, EarlyView.
Across scientific, technological, commercial, and pharmacological domains, individuals and organizations disengage from a previously adopted practice not at random, but as their network neighbors detach. The probability of detachment rises with the number of neighbors who have already disengaged. Preferential detachment reshapes network disintegration,
Binglu Wang, Ching Jin, Chaoming Song, Johannes Bjelland, Brian Uzzi, Dashun Wang   +5 more
wiley   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Wpływ powstania styczniowego na losy rodziny Morgiewiczów z Hanelek w powiecie lidzkim guberni wileńskiej

Prace Historyczne
The article presents the impact of the January Uprising on the fate of a Polish noble family in the lands of the former Grand Duchy of Lithuania, which had been involved in the independence uprising ...
Dariusz Tarasiuk
doaj   +1 more source

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

Egyptian Journalistic Professionalism in the Context of Revolution: Comparing Survey Results from Before and After the January 25, 2011 Uprising

International Journal of Communication, 2014
This study presents the results of two comparative surveys of Egyptian print journalists carried out in late 2008 and June 2013, respectively. The surveys aimed to assess aspects of Egyptian print journalism practice and professionalism at two different
Mohamad Hamas Elmasry, Dina Mohamed Basiony, Sara Farag Elkamel   +2 more
doaj  

Their Words, Their Deeds. The January Uprising in the Memory of Women (1864–1914)

Czasopismo Naukowe Instytutu Studiów Kobiecych
This article examines lesser-known dimensions of women’s memory of the January Uprising, focusing on the emotional experiences of female participants and observers of the events of 1863–1864. It primarily considers autobiographical memory, reconstructed from diaries and memoirs written by women who lived through the insurrection.
openaire   +1 more source

Optical Access to Dark Excitons Via Spin–Phonon Fano Interference

Advanced Science, EarlyView.
Dark excitons in quantum dots neither absorb nor emit light and stay hidden from optical spectroscopy. Quantum interference now reveals them: light scattered by acoustic phonons interferes with a phonon‐assisted spin flip between bright and dark exciton, carving a Fano dip into the spectrum whose position gives the bright–dark splitting. Magnetic field,
Janina J. Schindler, Katja Barthelmi, Mikhail M. Glazov, Carlo Sgroi, Sven Scholz, Arne Ludwig, Andreas D. Wieck, Jörg Debus   +7 more
wiley   +1 more source