Results 341 to 350 of about 399,504 (355)

Identification of 4-(2-furanyl)pyrimidin-2-amines as Janus kinase 2 inhibitors

Bioorganic & Medicinal Chemistry, 2017
Janus kinases inhibitor is considered to have therapeutic potential for the treatment of oncology and immune-inflammatory diseases. Two series of 4-(2-benzofuranyl)pyrimidin-2-amine and 4-(4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-yl)pyrimidin-2-amine derivatives have been designed and synthesized.
Yazhou, Wang, Wei, Huang, Minhang, Xin, Pan, Chen, Li, Gui, Xinge, Zhao, Feng, Tang, Jia, Wang, Fei, Liu   +8 more
openaire   +2 more sources

Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

MedChemComm, 2012
Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.
Chung-Hang Leung, Hui Yang, Victor Pui-Yan Ma, Daniel Shiu-Hin Chan, Hai-Jing Zhong, Ying-Wei Li, Wang-Fun Fong, Dik-Lung Ma   +7 more
openaire   +1 more source

Successful therapy for pyoderma gangrenosum with a Janus kinase 2 inhibitor

British Journal of Dermatology, 2018
S. Nasifoglu, B. Heinrich, J. Welzel
semanticscholar   +1 more source

CircScd1 Promotes Fatty Liver Disease via the Janus Kinase 2/Signal Transducer and Activator of Transcription 5 Pathway

Digestive Diseases and Sciences, 2018
Peifei Li, Keshu Shan, Yi Liu, Yu Zhang, Lu Xu, Lei Xu   +5 more
semanticscholar   +1 more source

Janus kinase-2 mutation, cirrhosis and splanchnic vein thrombosis

European Journal of Gastroenterology & Hepatology, 2008
COLAIZZO D, AMITRANO L, GUARDASCIONE MA, BALZANO A, MARGAGLIONE, MAURIZIO   +4 more
openaire   +2 more sources

The Development and Use of Janus Kinase 2 Inhibitors for the Treatment of Myeloproliferative Neoplasms.

Hematology/Oncology Clinics of North America, 2017
G. Hobbs, Sarah S. Rozelle, A. Mullally
semanticscholar   +1 more source

An Improved Synthesis of the Free Base and Diglycolate Salt of CEP-33779; A Janus Kinase 2 Inhibitor

, 2016
Daniel V. Levy, J. Sclafani, R. Bakale
semanticscholar   +1 more source

Janus-kinase-2 relates directly to portal hypertension and to complications in rodent and human cirrhosis

Gut, 2015
S. Klein, J. Rick, J. Lehmann, R. Schierwagen, Irela Schierwagen, L. Verbeke, K. Hittatiya, F. Uschner, S. Manekeller, C. Strassburg, K. Wagner, P. Sayeski, D. Wolf, W. Laleman, T. Sauerbruch, J. Trebicka   +15 more
semanticscholar   +1 more source

Calreticulin gene mutations in myeloproliferative neoplasms without Janus kinase 2 mutations

Leukemia and Lymphoma, 2015
Chao Sun, Sujiang Zhang, Jianyong Li
semanticscholar   +1 more source

Putamina Involvement in Wernicke Encephalopathy Induced by Janus Kinase 2 Inhibitor

Clinical neuropharmacology, 2015
Jorge Rodríguez-Pardo, I. Puertas-Muñoz, P. Martínez-Sánchez, Javier Díaz de Terán, I. Pulido-Valdeolivas, B. Fuentes   +5 more
semanticscholar   +1 more source