Results 111 to 120 of about 51,251 (187)

Molecular Structure and Function of Janus Kinases: Implications for the Development of Inhibitors. [PDF]

J Crohns Colitis, 2020
Garrido-Trigo A, Salas A.
europepmc   +1 more source

The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis. [PDF]

, 2015
ObjectiveTofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). The pathways affected by tofacitinib and the effects on gene expression in situ are unknown.
Boyle, DL, Bradley, J, Firestein, GS, Hodge, J, Kaplan, I, Kavanaugh, A, Krishnaswami, S, Luo, Z, Mandel, D, Mease, P, Rosengren, S, Shurmur, R, Singhal, AK, Soma, K, Wei, N   +14 more
core  

Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia.

Blood, 2021
Chang Y, Min J, Jarusiewicz JA, Actis M, Yu-Chen Bradford S, Mayasundari A, Yang L, Chepyala D, Alcock LJ, Roberts KG, Nithianantham S, Maxwell D, Rowland L, Larsen R, Seth A, Goto H, Imamura T, Akahane K, Hansen BS, Pruett-Miller SM, Paietta EM, Litzow MR, Qu C, Yang JJ, Fischer M, Rankovic Z, Mullighan CG.   +26 more
europepmc   +1 more source

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution. [PDF]

Pharmacol Rev, 2020
Bharadwaj U, Kasembeli MM, Robinson P, Tweardy DJ.   +3 more
europepmc   +1 more source

Janus kinase

, 2019
Yuranga Weerakkody, Arlene Campos, Daniel Bell   +2 more
openaire   +1 more source

STAT-independent functions of Janus kinases 1 and 2 are obligatory for the postnatal development of mammary epithelial ducts. [PDF]

Cell Rep
Dennaoui R, Wicker MN, Moen C, Schlederer M, Vistisen K, Triplett AA, Rülicke T, Rui H, Kenner L, Casanova E, Wagner KU.   +10 more
europepmc   +1 more source

Pharmacological inhibition of the Janus Kinases enhances ASCL1 protein stability and transcriptional activity. [PDF]

Mol Biol Rep
Hanspal MA, Presland J, Shkura K, Veiga MK, Gillotin S.   +4 more
europepmc   +1 more source

Effect of 6,7-dimethoxy-2,2-dimethyl-2H-chromene (agerarin) on the recovery of filaggrin expression through targeting of Janus kinases in the inflammatory skin. [PDF]

J Food Drug Anal, 2020
Ahn SS, Lee YH, Yeo H, Lee Y, Min DS, Lim Y, Shin SY.   +6 more
europepmc   +1 more source

Epigenomic landscapes define differential Janus kinases inhibitor sensitivity in IFN-γ-primed human macrophages. [PDF]

iScience
Kwon G, Park Y, Kang K, Park-Min KH, Kang K.   +4 more
europepmc   +1 more source

FDA-approved small-molecule kinase inhibitors [PDF]

, 2015
Clausen, Mads Hartvig, Nielsen, Thomas E., Wu, Peng   +2 more
core   +1 more source