Results 91 to 100 of about 5,595,628 (303)

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Why Not Change the Working Style of Men in Japan? [PDF]

open access: yes
In 1988, the total fertility rate (TFR, the number of children per family) of Japan was 1.38, recording a historic low. To date, there is little sign of any stop to this fertility decline.
Takayama, Noriyuki
core  

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Finding Common Interests in the Times of Rising Conflict: Shibusawa Eiichi and the 1909 Japanese Commercial Commission to the United States [PDF]

open access: yes, 2014
The 1909 Japanese Commercial Commission to the United States, its purpose, and its perception within the United States public and government, is analyzed using U.S. newspapers’ coverage of the Commission over the duration of its approximately three-month
Owen, Sydney M.
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

The use of equity positions by banks: the Japanese evidence [PDF]

open access: yes
Bank stocks ; Banks and banking - Japan ; Japan ...
Sun Bae Kim
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Japonya’da Deflasyon Döneminde İşsizlik ve İşsizlikle Mücadele

open access: yesLectio Socialis, 2020
Bu çalışmada Japonya’da deflasyon döneminde yaşanan işsizlik, işsizliğin ekonomide meydana getirdiği sorunlar ve mücadele politikaları incelenmiştir.
Özlem Yılmaz, Akyol Şahi̇n
doaj  

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