Results 101 to 110 of about 655,852 (304)
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Weakened pacific overturning circulation, winter monsoon dominance and tectonism re-organized Japan Sea paleoceanography during the Late Miocene global cooling. [PDF]
Sci Rep, 2022 Matsuzaki KM, Ikeda M, Tada R.
europepmc +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Известия ТИНРО, 2019 Current state of the mussel Crenomytilus grayanus stock in the coastal waters of Primorsky Region (Japan Sea) is considered on the base of diving surveys conducted in 2007–2018.
L. G. Sedova, D. A. Sokolenko
doaj +1 more source
Conflict in the East China Sea: would ANZUS apply? [PDF]
This paper analyses the circumstances under which conflict in the East China Sea could occur and the implications for Australia. Executive summary Tensions between China and Japan have ratcheted up in recent years to the point where their territorial ...
Brendan Taylor, Nick Bisley
core
The Straits of Malacca: Regional powers vis-a-vis littoral states in strategic and security issues and interests [PDF]
, 2010 This paper presents an overview of the strategic and security issues surrounding the Straits of Malacca. It begins by introducing the strategic nature of the Straits of Malacca and piracy threat in the busy sea lane. Subsequently this paper discusses the
Ismail, Siti Zubaidah +1 more
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Areal distribution of water-insoluble particles in snow covers of the central mountainous area, Japan [PDF]
, 2012 The vertical snow samples collected from 6 locations (Iou-zen: 800m A.M.S.L; the nearest site from the Sea of Japan, Kongoudou-zan: 1300m, Nishi-Hodaka-Dake: 2200m; the Northern Japan Alps, Hachimori-yama: 2100m, Kiriga-mine: 2000m, Yatsuga-take: 2200m ...
Kawada, Kunio +3 more
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source