Results 111 to 120 of about 1,530,417 (316)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Perception of Adherence to Daily Human Growth Hormone Treatments Among Pediatric and Adolescent Patients in Japan: A Cross-Sectional Survey of Physicians and Caregivers

open access: yesPatient Preference and Adherence, 2022
Manabu Akazawa,1 Daisuke Shima,2 Takahiro Sato,2 Emi Shoji,2 Michael LoPresti,3 Ryosuke Nishi3 1Department of Public Health and Epidemiology, Meiji Pharmaceutical University, Tokyo, Japan; 2Medical Affairs, Rare Disease, Pfizer Japan Inc, Tokyo, Japan ...
Akazawa M   +5 more
doaj  

Florin Chapter of Japanese American Citizens' League documents on choral speaking

open access: yes, 1944
Instructional document on "choral speaking" with poems. Includes "The Gypsies," "The Baseball Game," "Wasted Word," "Clouds," and "The Night Wind."The Japanese American Archival Collection documents the people, places, and daily life of Japanese ...
Japanese American Citizens' League: publisher
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Japanese and non-Japanese perceptions of Japanese communication

open access: yes, 2003
Perceptions of the communicative style of different languages can influence the way in which non-native speakers and native speakers of a particular language interact. For example, second-language learners of Japanese often believe that using a lot of honorifics (keigo) to introduce themselves to other students at universities in Japan is more polite ...
openaire   +1 more source

Japanese passport, Chitoshi Horita

open access: yes, 1923
A Japanese passport for Chitoshi (Harry) Horita. There is a stamp on the passport from showing Chitoshi was admitted to the U.S. in San Francisco, California in December of 1923.The Horita Family Papers (1940-2010, undated) collection contains documents ...
The Imperial Japanese Government: creator
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

What a nominal predicate may mean: eel, merfolk, and other creatures

open access: yesLinguistics
A nominal predicate construction (NPC; e.g. “Cicero is {Tully/an orator}”) typically indicates the relation of identity or inclusion. NPCs, however, may receive marked interpretations as well, as in “I’m the ham sandwich” and “Their car is a peculiar ...
Oshima David Y.
doaj   +1 more source

Translating the biblical key word ḥeseḏ into Arabic and Japanese: A theological and comparative semantic study

open access: yesRussian Journal of Linguistics
Translating culturally and religiously loaded words presents a challenge for translators. The nuanced meanings of these words risk being lost or distorted in the target language.
Sandy Habib, Hiromichi Sakaba
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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