Results 101 to 110 of about 3,749,304 (354)

FRASA ADJEKTIVA BAHASA JEPANG: ANALISIS X-BAR

Lingua: Jurnal Bahasa, Sastra dan Pengajarannya, 2017
The structure and principles of how to form adjective phrases in Japanese were investigated in this study. This qualitative study used content analysis as the research design and assigned Japanese Textbooks used for Japanese Course as the source of data.
Puti Novianti Aristia
doaj   +1 more source

Classifiers in Japanese-to-English Machine Translation

, 1996
This paper proposes an analysis of classifiers into four major types: UNIT, METRIC, GROUP and SPECIES, based on properties of both Japanese and English.
Bond, Francis, Ikehara, Satoru, Ogura, Kentaro   +2 more
core   +2 more sources

Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals

Nature Communications, 2015
The Tohoku Medical Megabank Organization reports the whole-genome sequences of 1,070 healthy Japanese individuals and construction of a Japanese population reference panel (1KJPN). Here we identify through this high-coverage sequencing (32.4 × on average)
Masao Nagasaki, J. Yasuda, F. Katsuoka, Naoki Nariai, Kaname Kojima, Y. Kawai, Yumi Yamaguchi-Kabata, J. Yokozawa, I. Danjoh, Sakae Saito, Yukuto Sato, Takahiro Mimori, K. Tsuda, Rumiko Saito, Xiaoqing Pan, Satoshi Nishikawa, Shin Ito, Y. Kuroki, Osamu Tanabe, N. Fuse, S. Kuriyama, H. Kiyomoto, A. Hozawa, N. Minegishi, James Douglas Engel, K. Kinoshita, S. Kure, N. Yaegashi, Akito Fuji Hiroshi Hiroaki Ichiro Jun Junichi Kichiya Ma Tsuboi Nagami Kawame Tomita Tsuji Nakaya Sugawara , A. Tsuboi, F. Nagami, H. Kawame, Hiroaki Tomita, I. Tsuji, J. Nakaya, J. Sugawara, Kichiya Suzuki, M. Kikuya, Michiaki Abe, N. Nakaya, Noriko Osumi, R. Yamashita, S. Ogishima, Takako Takai, T. Tominaga, Yasuyuki Taki, Yoichi Suzuki, Masayuki Yamamoto   +47 more
semanticscholar   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Japanese medical researchers’ perceptions of quantitative research evaluation metrics and their psychological well-being: a cross-sectional study

Environmental Health and Preventive Medicine
Background: Supporting the mental health of researchers is essential to maintaining human resources and advancing science. This study investigated the association between Japanese medical researchers’ perceptions of research evaluation processes and ...
Akira Minoura, Keisuke Kuwahara, Yuhei Shimada, Hiroko Fukushima, Makoto Kondo, Takehiro Sugiyama   +5 more
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Sedentary Behavior and Health Consequences: A Systematic Scoping Review of Prospective and Longitudinal Studies in Japan

Journal of Epidemiology
Objectives: This scoping review summarizes and evaluates evidence from Japan on prospective relationships of sedentary behavior (too much sitting, as distinct from too little physical activity) with health outcomes, forming the basis for Japan’s new ...
Ai Shibata, Kaori Ishii, Neville Owen, Koichiro Oka   +3 more
doaj   +1 more source