Results 81 to 90 of about 488,149 (267)
International Journal of COPD, 2021 Takumi Yamaguchi,1,2 Akio Yamamoto,2,3 Yutaro Oki,2 Hideki Sakai,1 Shogo Misu,1,4 Yusuke Iwata,2 Masahiro Kaneko,5 Kaku Sawada,6 Yukari Oki,2 Yuji Mitani,2 Kumiko Ono,2 Akira Ishikawa2 1Department of Rehabilitation, Kobe City Hospital Organization, Kobe ...
Yamaguchi T +11 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Patient Preference and Adherence, 2022 Manabu Akazawa,1 Daisuke Shima,2 Takahiro Sato,2 Emi Shoji,2 Michael LoPresti,3 Ryosuke Nishi3 1Department of Public Health and Epidemiology, Meiji Pharmaceutical University, Tokyo, Japan; 2Medical Affairs, Rare Disease, Pfizer Japan Inc, Tokyo, Japan ...
Akazawa M +5 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
What a nominal predicate may mean: eel, merfolk, and other creatures
LinguisticsA nominal predicate construction (NPC; e.g. “Cicero is {Tully/an orator}”) typically indicates the relation of identity or inclusion. NPCs, however, may receive marked interpretations as well, as in “I’m the ham sandwich” and “Their car is a peculiar ...
Oshima David Y.
doaj +1 more source
Investigating Copyright Terminology and Collocations in Polish, English, Japanese and German
Studies in Logic, Grammar and Rhetoric, 2017 The article deals with the comparison of key terminology in the field of copyright in the Polish, English, Japanese and German languages. The research material consists of copyright acts binding in Poland, Great Britain, the United States of America ...
Trzaskawka Paula
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Japanese and non-Japanese perceptions of Japanese communication
, 2003 Perceptions of the communicative style of different languages can influence the way in which non-native speakers and native speakers of a particular language interact. For example, second-language learners of Japanese often believe that using a lot of honorifics (keigo) to introduce themselves to other students at universities in Japan is more polite ...
openaire +2 more sources
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source