Results 71 to 80 of about 1,749,918 (303)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Fault and Infelicity – Apologies in Polish and Japanese
Półrocznik Językoznawczy Tertium, 2016 Genres of speech may serve different pragmatic functions in various communication environments. In some cases these functions may reveal differences unintelligible for nonnative users of language and culture.
Arkadiusz Jabłoński
doaj +1 more source
Membership, Japanese American Citizens League Oath of Allegiance
, 1942 Japanese American Citizens League Oath of Allegiance, signed by Frank Yamasaki. Stamped seal can be seen in lower left area. 1 page, single sided. Paper, ink.Collected by Masao Umeda during the forced incarceration of Japanese Americans during World War ...
Japanese American Citizens League
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
, 1994 The Japanese have ambivalent attitudes toward death, deeply rooted in pre-Buddhist traditions. In this scholarly but accessible work, authors Iwasaka and Toelken show that everyday beliefs and customs--particularly death traditions--offer special insight into the living culture of Japan.
Toelken Barre, Iwasaka, Michiko
openaire +2 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
What is Gained in Subtitling: How Film Subtitles Can Expand the Source Text
TranscUlturAl, 2015 The problem of translation and loss is a cardinal concern in translation studies. Conventional wisdom tells us that translation must necessarily entail loss.
Tom Kabara
doaj +1 more source