Results 21 to 30 of about 198,176 (262)

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Annual dialysis data report 2022, Japanese Society for Dialysis Therapy (JSDT) Renal Data Registry

Renal Replacement Therapy
The annual survey of the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) was sent to 4521 dialysis facilities at the end of 2022, among which 4464 facilities (98.7%) responded to the facility survey, and 4276 facilities (94.6%) responded
Norio Hanafusa, Masanori Abe, Nobuhiko Joki, Junichi Hoshino, Masatomo Taniguchi, Kan Kikuchi, Takeshi Hasegawa, Shunsuke Goto, Tetsuya Ogawa, Eiichiro Kanda, Shigeru Nakai, Toshihide Naganuma, Kenichiro Miura, Atsushi Wada, Yoshiaki Takemoto   +14 more
doaj   +1 more source

Validation of data quality in a nationwide gastroenterological surgical database: The National Clinical Database site‐visit and remote audits, 2016‐2018

Annals of Gastroenterological Surgery, 2021
Background and Aim In 2015, the Japanese Society of Gastroenterological Surgery (JSGS) initiated data verification in the gastroenterological section of the National Clinical Database (NCD) and reported high accuracy of data entry.
Hiroshi Hasegawa, Arata Takahashi, Shingo Kanaji, Yoshihiro Kakeji, Shigeru Marubashi, Hiroyuki Konno, Mitsukazu Gotoh, Hiroaki Miyata, Yuko Kitagawa, Yasuyuki Seto   +9 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Annual dialysis data report 2021, Japanese Society for Dialysis Therapy (JSDT) renal data registry

Renal Replacement Therapy
The annual survey of the Japanese Society for Dialysis Therapy (JSDT) Renal Data Registry (JRDR) at the end of 2021 was conducted at 4508 facilities, of which 4454 facilities (98.8%) returned the facility questionnaire and 4251 (94.3%) returned the ...
Norio Hanafusa, Masanori Abe, Nobuhiko Joki, Junichi Hoshino, Atsushi Wada, Kan Kikuchi, Shunsuke Goto, Tetsuya Ogawa, Eiichiro Kanda, Masatomo Taniguchi, Shigeru Nakai, Toshihide Naganuma, Takeshi Hasegawa, Kenichiro Miura, Yoshiaki Takemoto, on behalf of Japanese Society for Dialysis Therapy Renal Data Registry Committee   +15 more
doaj   +1 more source

Surgical outcomes in gastroenterological surgery in Japan: Report of the National Clinical Database 2011‐2018

Annals of Gastroenterological Surgery, 2020
The National Clinical Database (NCD) of Japan grew rapidly, harvesting over 11 million cases of data between 2011 and 2018 from more than 5000 facilities.
Yoshihiro Kakeji, Arata Takahashi, Hiroshi Hasegawa, Hideki Ueno, Susumu Eguchi, Itaru Endo, Akira Sasaki, Shuji Takiguchi, Hiroya Takeuchi, Masaji Hashimoto, Akihiko Horiguchi, Tadahiko Masaki, Shigeru Marubashi, Kazuhiro Yoshida, Mitsukazu Gotoh, Hiroyuki Konno, Hiroyuki Yamamoto, Hiroaki Miyata, Yasuyuki Seto, Yuko Kitagawa, National Clinical Database   +20 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source