Results 41 to 50 of about 1,022,723 (297)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Lesbians and Transgenders in Japanese Media [PDF]

, 2010
Japanese GLBT appear to have always held a place in national media. From the the Edo period to the modern age, the Japanese people have constantly been exposed to different types of GLBT society, whether or not they realized it at the time. In this paper,
Caldart, Regina E.
core  

Highlights of the Science and Life of Peter Varga (1946—2018)

, 2020
Peter Varga has passed on October 27, 2018. His pioneering discoveries of chemical resolution at the atomic scale on surface alloys, atomic resolution of ultrathin alkali halides, nucleation of bcc iron in ultrathin films, and the microscopic structure ...
Aumayr, F., Diebold, U., Schneider, W.
core   +1 more source

Importance of Acid–Base Equilibrium in Electrocatalytic Oxidation of Formic Acid on Platinum [PDF]

, 2013
This work was supported by Japanese Society for the Promotion of Science (JSPS) KAKENHI Grants Nos. 24550143 and 24750117 and MEXT Project of Integrated Research on Chemical Synthesis. M.T.M.K. gratefully acknowledges the award of Long-Term Fellowship of
Cuesta, Angel, Joo, Jiyong, Koper, Marc T. M., Osawa, Masatoshi, Uchida, Taro   +4 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Annual dialysis data report 2020, JSDT renal data registry

Renal Replacement Therapy
Background The 2020 Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) annual survey was sent to 4493 dialysis facilities in Japan. Methods Questionnaires were sent to all facilities that provide patients with dialysis therapy in Japan ...
Norio Hanafusa, Masanori Abe, Nobuhiko Joki, Junichi Hoshino, Kan Kikuchi, Shunsuke Goto, Eiichiro Kanda, Masatomo Taniguchi, Shigeru Nakai, Toshihide Naganuma, Takeshi Hasegawa, Kenichiro Miura, Atsushi Wada, Yoshiaki Takemoto, Japanese Society for Dialysis Therapy Renal Data Registry Committee   +14 more
doaj   +1 more source

Effects of Physiotherapeutic Scoliosis-Specific Exercise for Adolescent Idiopathic Scoliosis Cobb Angle: A Systematic Review

Spine Surgery and Related Research
Background: The study of physiotherapeutic scoliosis-specific exercise (PSSE) for adolescent idiopathic scoliosis (AIS) is rapidly progressing. However, there are limited reports on the medium- to long-term effects of PSSE on scoliosis.
Hiroki Oba, Kei Watanabe, Tomoyuki Asada, Akira Matsumura, Ryo Sugawara, Shinji Takahashi, Haruki Ueda, Satoshi Suzuki, Toru Doi, Takumi Takeuchi, Hideyuki Arima, Yu Yamato, Satoru Demura, Naobumi Hosogane   +13 more
doaj   +1 more source

Japanese Guideline for Childhood Asthma 2014

Allergology International, 2014
The Japanese Guideline for the Diagnosis and Treatment of Allergic Diseases 2013 (JAGL 2013) describes childhood asthma after the Japanese Pediatric Guideline for the Treatment and Management of Asthma 2012 (JPGL 2012) by the Japanese Society of ...
Yuhei Hamasaki, Yoichi Kohno, Motohiro Ebisawa, Naomi Kondo, Sankei Nishima, Toshiyuki Nishimuta, Akihiro Morikawa   +6 more
doaj   +1 more source

Dialyzer surface area is a significant predictor of mortality in patients on hemodialysis: a 3-year nationwide cohort study

Scientific Reports, 2021
A target Kt/V of > 1.4 and use of a high-flux dialyzer are recommended for patients on hemodialysis. However, there is little information on the relationship between the dialyzer surface area and mortality in these patients.
Masanori Abe, Ikuto Masakane, Atsushi Wada, Shigeru Nakai, Kosaku Nitta, Hidetomo Nakamoto   +5 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source